Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)

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Potential Therapeutic Anti-Inflammatory and Immunomodulatory Effects of Dihydroflavones, Flavones, and Flavonols

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Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases

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(2020) Michael Letko et al.   Nature Microbiology

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In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease

(2020) Tien Huynh et al.   Journal of Physical Chemistry Letters

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(2020) Chae Hyun Kim et al.   MOLECULES

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(2020) Jun Lan et al.   NATURE

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(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

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(2020) Yan Gao et al.   SCIENCE

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(2020) Ling Zhong et al.   Science China-Life Sciences

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(2020) Chunyan Wang et al.   Nature Communications

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy

(2020) Bhupesh Goyal et al.   ACS Combinatorial Science

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

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(2020) Susan R Wilcox   BMJ-British Medical Journal

Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19

(2020) Jiansheng Huang et al.   Journal of Clinical Medicine

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

(2020) Gaber El-Saber Batiha et al.   Foods

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(2020) Gang Gong et al.   BIOMEDICINE & PHARMACOTHERAPY

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(2020) Yu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

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(2020) Brice Ayissi Owona et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

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(2020) L. Wang   MEDECINE ET MALADIES INFECTIEUSES

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(2020) Wilfred Ngwa et al.   MOLECULES

Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review

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(2020) Daan F. van den Berg et al.   Frontiers in Immunology

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

(2020) Ruben Manuel Luciano Colunga Biancatelli et al.   Frontiers in Immunology

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(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Aromatic Herbs, Medicinal Plant-Derived Essential Oils, and Phytochemical Extracts as Potential Therapies for Coronaviruses: Future Perspectives

(2020) Mohamed Nadjib Boukhatem et al.   Plants-Basel

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(2020) Maria Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials against COVID-19: An in-silico Evaluation

(2020) Uma Sankar Gorla et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2

(2020) Muchtaridi Muchtaridi et al.   MOLECULES

Role of MAPK/NF-κB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats

(2019) Vipin Kumar Verma et al.   MOLECULAR BIOLOGY REPORTS

Recent Aspects on the Pathogenesis Mechanism, Animal Models and Novel Therapeutic Interventions for Middle East Respiratory Syndrome Coronavirus Infections

(2019) Sinosh Skariyachan et al.   Frontiers in Microbiology

Flavonol 7-O-Glucoside Herbacitrin Inhibits HIV-1 Replication through Simultaneous Integrase and Reverse Transcriptase Inhibition

(2019) Éva Áy et al.   Evidence-based Complementary and Alternative Medicine

Protective effect of 7,3′,4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo

(2019) Licong Zhao et al.   PHYTOMEDICINE

Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats

(2019) Hany Elsawy et al.   PeerJ

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

(2019) Seri Jo et al.   Chemical Biology & Drug Design

Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats

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Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

Antiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds

(2019) Min Jung Kwon et al.   JOURNAL OF APICULTURAL RESEARCH

The Protective Effects of Myricetin against Cardiovascular Disease

(2019) Lu WANG et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Dose- dependent ameliorative effects of quercetin and l -Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats

(2018) Rabie L. Abdel Aziz et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of flavonoids in autoimmune diseases: therapeutic updates

(2018) Kannan R.R. Rengasamy et al.   PHARMACOLOGY & THERAPEUTICS

Catalytic, antioxidant and anticancer activities of gold nanoparticles synthesized by kaempferol glucoside from Lotus leguminosae

(2018) Mohamed Habib Oueslati et al.   Arabian Journal of Chemistry

Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

(2018) Sarwat Jahan et al.   BMC Urology

Kaempferol-3-O-glucorhamnoside inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo

(2018) Zhuojian Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity

(2017) Ya-Di Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

(2017) Ji-Young Park et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice

(2017) Samar M. Hassan et al.   PHARMACEUTICAL BIOLOGY

The Pharmacological Potential of Rutin

(2017) Aditya Ganeshpurkar et al.   SAUDI PHARMACEUTICAL JOURNAL

Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts

(2017) Gansukh Enkhtaivan et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

(2016) Xiangguo Qiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells

(2016) Jin-Young Park et al.   Biomolecules & Therapeutics

Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects

(2016) Raju Gautam et al.   BMC Complementary and Alternative Medicine

Systems Pharmacology Dissection of the Protective Effect of Myricetin Against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart

(2016) Yingna Qiu et al.   Cardiovascular Toxicology

Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine

(2016) Seyed Fazel Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators

(2016) Chitra Dhanasekar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress

(2016) Meghana Koneru et al.   Journal of Functional Foods

Myricetin: A Dietary Molecule with Diverse Biological Activities

(2016) Deepak Semwal et al.   Nutrients

Hepatoprotective Effect of Kaempferol Against Alcoholic Liver Injury in Mice

(2015) Meng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

In vivo anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica (L.) Mill cladodes

(2015) Marilena Antunes-Ricardo et al.   INDUSTRIAL CROPS AND PRODUCTS

Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. on CCl4-induced oxidative liver injury in mice

(2015) Yu Wang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Metabolism of Rutin and Poncirin by Human Intestinal Microbiota and Cloning of Their Metabolizing ��-L-Rhamnosidase from Bifidobacterium dentium

(2015) Seo-Hyeon Bang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation

(2015) Wenlu Li et al.   JOURNAL OF NEUROCHEMISTRY

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats

(2015) V. Umarani et al.   TOXICOLOGY MECHANISMS AND METHODS

Hydrolysis of the Rutinose-Conjugates Flavonoids Rutin and Hesperidin by the Gut Microbiota and Bifidobacteria

(2015) Alberto Amaretti et al.   Nutrients

Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats

(2015) V. Umarani et al.   TOXICOLOGY MECHANISMS AND METHODS

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza

(2015) Ahmed Abdal Dayem et al.   PLoS One

Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases

(2015) Daniel Grenier et al.   PLoS One

Isoquercitrin: Pharmacology, toxicology, and metabolism

(2014) Kateřina Valentová et al.   FOOD AND CHEMICAL TOXICOLOGY

The Effects of Morin on Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the Lung NLRP3 Inflammasome

(2014) Zhang Tianzhu et al.   INFLAMMATION

p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

(2014) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Protective Effects of Kaempferol on Isoniazid- and Rifampicin-Induced Hepatotoxicity

(2013) Tung-Yuan Shih et al.   AAPS Journal

O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation

(2013) Ji Hye Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

The Antioxidant Effects of Isorhamnetin Contribute to Inhibit COX-2 Expression in Response to Inflammation: A Potential Role of HO-1

(2013) Kyuhwa Seo et al.   INFLAMMATION

Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice

(2013) Toshiaki Makino et al.   Journal of Natural Medicines

Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury

(2013) Sanja Matić et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Anticoagulant activities of persicarin and isorhamnetin

(2013) Sae-Kwang Ku et al.   VASCULAR PHARMACOLOGY

Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

(2012) Thi Thanh Hanh Nguyen et al.   BIOTECHNOLOGY LETTERS

Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects

(2012) Eleonora Derlindati et al.   Food & Function

In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue

(2011) Seyed Mohammad Nabavi et al.   FOOD CHEMISTRY

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats

(2011) Cíntia de David et al.   TOXICOLOGIC PATHOLOGY

Inhibition of influenza virus replication by plant-derived isoquercetin

(2010) Yunjeong Kim et al.   ANTIVIRAL RESEARCH

Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats

(2010) Akula Annapurna et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protective Effect of Quercetin on the Reproductive Toxicity of 4-nitrophenol in Diesel Exhaust Particles on Male Embryonic Chickens

(2010) Yuling MI et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action

(2009) Zhi Hong Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose-induced oxidative damage

(2009) Yun Jung Lee et al.   PHYTOTHERAPY RESEARCH