Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

(2020) Patrick J. Sarver et al.   Nature Chemistry

GABA Analogues and Related Mono-/Bifunctional Building Blocks Derived from the Fluorocyclobutane Scaffold

(2020) Illia O. Feskov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks

(2019) Anton V. Chernykh et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

(2019) David J. P. Kornfilt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The cyclopropylcarbinyl route to γ-silyl carbocations

(2019) Xavier Creary   Beilstein Journal of Organic Chemistry

Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives

(2019) Maksym Bugera et al.   JOURNAL OF ORGANIC CHEMISTRY

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

(2018) Jacob A. Kautzky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 3-Azabicyclo[3.2.0]heptane-derived Building Blocks via [3+2] Cycloaddition

(2018) Anton A. Homon et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)–H Direct Fluorination

(2018) Qiang Wei et al.   ORGANIC LETTERS

Cyclobutyl-Containing Rigid Analogues of Threonine: Synthesis and Physical Chemical Properties

(2017) Illia O. Feskov et al.   JOURNAL OF ORGANIC CHEMISTRY

Cs2CO3-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

(2017) et al.   MOLECULES

Effect of Partially FluorinatedN-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

(2016) Raffael Vorberg et al.   ChemMedChem

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

(2015) Bruno Linclau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

(2015) Quentin A. Huchet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simple Vector Considerations to Assess the Polarity of Partially Fluorinated Alkyl and Alkoxy Groups

(2014) Klaus Müller   CHIMIA

Highly Potent HCV NS4B Inhibitors with Activity against Multiple Genotypes

(2014) Barton Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

(2014) Anton V. Chernykh et al.   RSC Advances

On the polarity of partially fluorinated methyl groups

(2013) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent

(2013) Dmytro S. Radchenko et al.   TETRAHEDRON LETTERS

Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds

(2012) David O'Hagan et al.   PURE AND APPLIED CHEMISTRY

Confining the χ space of basic natural amino acids: cyclobutane-derived χ1,χ2-constrained analogues of arginine, lysine and ornithine

(2012) Dmytro S. Radchenko et al.   TETRAHEDRON

Discovery of Two Clinical Histamine H3Receptor Antagonists:trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) andtrans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

(2011) Travis T. Wager et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expedient Synthesis ofcis- andtrans-3-Aminocyclobutanecarboxylic Acids

(2011) Dmytro S. Radchenko et al.   SYNTHETIC COMMUNICATIONS

Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist

(2010) Jinhwa Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclobutane-Derived Diamines: Synthesis and Molecular Structure

(2010) Dmytro S. Radchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent

(2009) Weiping Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

(2008) Yuping Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS