Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

Synthesis and Physicochemical Properties of 3-Fluorocyclobutylamines

(2015) Anton V. Chernykh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis and Physicochemical Properties of Libraries of 3-Amino- and 3-Amidofluoropiperidines

(2014) Aurélie Orliac et al.   CHEMISTRY-A EUROPEAN JOURNAL

Simple Vector Considerations to Assess the Polarity of Partially Fluorinated Alkyl and Alkoxy Groups

(2014) Klaus Müller   CHIMIA

The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipophilic efficiency: the most important efficiency metric in medicinal chemistry

(2013) Kevin D Freeman-Cook et al.   Future Medicinal Chemistry

Fluorosugars: An improved synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogue of d-glucose

(2013) Michael J. Corr et al.   JOURNAL OF FLUORINE CHEMISTRY

On the polarity of partially fluorinated methyl groups

(2013) Quentin A. Huchet et al.   JOURNAL OF FLUORINE CHEMISTRY

Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool

(2013) Marina Shalaeva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contributions of Molecular Properties to Drug Promiscuity

(2013) Ákos Tarcsay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity

(2013) J.-H. Kim et al.   SCIENCE

The Block Relevance (BR) analysis to aid medicinal chemists to determine and interpret lipophilicity

(2013) Giulia Caron et al.   MedChemComm

The influence of lipophilicity in drug discovery and design

(2012) John A Arnott et al.   Expert Opinion on Drug Discovery

Impact of Lipophilic Efficiency on Compound Quality

(2012) Ákos Tarcsay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

(2011) Robert J. Young et al.   DRUG DISCOVERY TODAY

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural, Mechanistic, and Computational Analysis of the Effects of Anomeric Fluorines on Anomeric Fluoride Departure in 5-Fluoroxylosyl Fluorides

(2011) Seung Seo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents

(2010) Huaping Mo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of d-glucose and d-altrose and assessment of their erythrocyte transmembrane transport

(2010) Stefano Bresciani et al.   CHEMICAL COMMUNICATIONS

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

(2010) Emanuele Perola   JOURNAL OF MEDICINAL CHEMISTRY

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine in Protein Environments: A QM and MD Study

(2009) Sergey A. Samsonov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS