Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry
出版年份 2021 全文链接
标题
Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry
作者
关键词
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出版物
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 1, Pages 87-95
出版商
Wiley
发表日期
2021-01-06
DOI
10.1002/ejoc.202001345
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation
- (2020) Patrick J. Sarver et al. Nature Chemistry
- GABA Analogues and Related Mono-/Bifunctional Building Blocks Derived from the Fluorocyclobutane Scaffold
- (2020) Illia O. Feskov et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks
- (2019) Anton V. Chernykh et al. JOURNAL OF ORGANIC CHEMISTRY
- Copper-Catalyzed Trifluoromethylation of Alkyl Bromides
- (2019) David J. P. Kornfilt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The cyclopropylcarbinyl route to γ-silyl carbocations
- (2019) Xavier Creary Beilstein Journal of Organic Chemistry
- Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives
- (2019) Maksym Bugera et al. JOURNAL OF ORGANIC CHEMISTRY
- Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
- (2018) Jacob A. Kautzky et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of 3-Azabicyclo[3.2.0]heptane-derived Building Blocks via [3+2] Cycloaddition
- (2018) Anton A. Homon et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)–H Direct Fluorination
- (2018) Qiang Wei et al. ORGANIC LETTERS
- Cyclobutyl-Containing Rigid Analogues of Threonine: Synthesis and Physical Chemical Properties
- (2017) Illia O. Feskov et al. JOURNAL OF ORGANIC CHEMISTRY
- Cs2CO3-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers
- (2017) et al. MOLECULES
- Effect of Partially FluorinatedN-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties
- (2016) Raffael Vorberg et al. ChemMedChem
- Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method
- (2015) Bruno Linclau et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
- (2015) Quentin A. Huchet et al. JOURNAL OF MEDICINAL CHEMISTRY
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Simple Vector Considerations to Assess the Polarity of Partially Fluorinated Alkyl and Alkoxy Groups
- (2014) Klaus Müller CHIMIA
- Highly Potent HCV NS4B Inhibitors with Activity against Multiple Genotypes
- (2014) Barton Phillips et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid
- (2014) Anton V. Chernykh et al. RSC Advances
- On the polarity of partially fluorinated methyl groups
- (2013) Quentin A. Huchet et al. JOURNAL OF FLUORINE CHEMISTRY
- An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent
- (2013) Dmytro S. Radchenko et al. TETRAHEDRON LETTERS
- Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds
- (2012) David O'Hagan et al. PURE AND APPLIED CHEMISTRY
- Confining the χ space of basic natural amino acids: cyclobutane-derived χ1,χ2-constrained analogues of arginine, lysine and ornithine
- (2012) Dmytro S. Radchenko et al. TETRAHEDRON
- Discovery of Two Clinical Histamine H3Receptor Antagonists:trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) andtrans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)
- (2011) Travis T. Wager et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expedient Synthesis ofcis- andtrans-3-Aminocyclobutanecarboxylic Acids
- (2011) Dmytro S. Radchenko et al. SYNTHETIC COMMUNICATIONS
- Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist
- (2010) Jinhwa Lee et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Cyclobutane-Derived Diamines: Synthesis and Molecular Structure
- (2010) Dmytro S. Radchenko et al. JOURNAL OF ORGANIC CHEMISTRY
- Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent
- (2009) Weiping Yu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
- (2008) Yuping Zhu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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