Genomics of High-Grade Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumor with High-Grade Features (G3 NET) and Neuroendocrine Carcinomas (NEC) of Various Anatomic Sites

SMARCA4-deficient Sinonasal Carcinoma

(2020) Abbas Agaimy et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature

(2020) Amedeo Sciarra et al.   ENDOCRINE PATHOLOGY

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

(2020) John T. Poirier et al.   Journal of Thoracic Oncology

Specific genomic alterations in high grade pulmonary neuroendocrine tumours with carcinoid morphology

(2020) Jérôme Cros et al.   NEUROENDOCRINOLOGY

Molecular studies of lung neuroendocrine neoplasms uncover new concepts and entities

(2020) Lynnette Fernandez-Cuesta et al.   Translational Lung Cancer Research

Long Non-coding RNAs in Pulmonary Neuroendocrine Neoplasms

(2020) Damodaran Narayanan et al.   ENDOCRINE PATHOLOGY

Well Differentiated Grade 3 Neuroendocrine Tumors of the Digestive Tract: A Narrative Review

(2020) Anna Pellat et al.   Journal of Clinical Medicine

On the Endless Dilemma of Neuroendocrine Neoplasms of the Breast: a Journey Through Concepts and Entities

(2020) Silvia Uccella et al.   ENDOCRINE PATHOLOGY

High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms

(2020) Ewelina Motylewska et al.   ENDOCRINE PATHOLOGY

Looking into digestive MiNENs: subtypes, prognosis and predictive factors

(2020) Silvia Uccella et al.   HISTOPATHOLOGY

Gastric Neuroendocrine Tumors from Long‐Term Proton Pump Inhibitor Users are Indolent Tumors with Good Prognosis

(2020) Vincent Quoc‐Huy Trinh et al.   HISTOPATHOLOGY

Lung carcinoids with high proliferative activity: Further support for the identification of a new tumor category in the classification of lung neuroendocrine neoplasms

(2020) M. Rubino et al.   LUNG CANCER

Comparative genomics of high grade neuroendocrine carcinoma of the cervix

(2020) R. Tyler Hillman et al.   PLoS One

Metastatic Castration-Resistant Prostate Cancer with Neuroendocrine Transformation and BRCA 1 Germ-Line Mutation: A Case Report and Literature Review

(2020) Yinhang Wu et al.   OncoTargets and Therapy

Multiple faces of pulmonary large cell neuroendocrine carcinoma: update with a focus on practical approach to diagnosis

(2020) Marina K. Baine et al.   Translational Lung Cancer Research

Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)

(2020) Alberto Puccini et al.   CLINICAL CANCER RESEARCH

Targeted Therapies in the Management of Well-Differentiated Digestive and Lung Neuroendocrine Neoplasms

(2020) Namrata Vijayvergia et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Genetic basis of SMARCB1 protein loss in 22 sinonasal carcinomas

(2020) Snjezana Dogan et al.   HUMAN PATHOLOGY

Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization

(2020) Marina K. Baine et al.   Journal of Thoracic Oncology

Molecular drivers and cells of origin in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine carcinoma

(2020) He-Li Gao et al.   Experimental Hematology & Oncology

New insights into the classification of gastric neuroendocrine tumours, expanding the spectrum of ECL‐cell tumours related to hypergastrinaemia

(2020) Stefano La Rosa et al.   HISTOPATHOLOGY

Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix

(2020) Adela Cimic et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Genetics and Epigenetics of Gastroenteropancreatic Neuroendocrine Neoplasms

(2019) Andrea Mafficini et al.   ENDOCRINE REVIEWS

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma

(2019) Zhen Zhou et al.   Thoracic Cancer

Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors

(2019) Jaclyn F. Hechtman et al.   PANCREAS

Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices

(2019) Natasha Rekhtman et al.   MODERN PATHOLOGY

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

(2019) Huanhuan Joyce Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted next-generation sequencing of well-differentiated rectal, gastric, and appendiceal neuroendocrine tumors to identify potential targets

(2019) Ha Young Park et al.   HUMAN PATHOLOGY

PD-L1, RB1 and mismatch repair protein immunohistochemical expression in neuroendocrine carcinoma, small cell type of the uterine cervix

(2019) Sarah Morgan et al.   HISTOPATHOLOGY

Recent advances in the molecular landscape of lung neuroendocrine tumors

(2019) Giuseppe Pelosi et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Neuroendocrine Neoplasms Associated with Germline Pathogenic Variants in the Homologous Recombination Pathway

(2019) Marta Szybowska et al.   ENDOCRINE PATHOLOGY

NEK2 Is an Effective Target for Cancer Therapy With Potential to Induce Regression of Multiple Human Malignancies

(2019) TOSHIO KOKURYO et al.   ANTICANCER RESEARCH

Molecular classification of neuroendocrine tumors of the thymus

(2019) Helen Dinter et al.   Journal of Thoracic Oncology

Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations

(2019) Michele Simbolo et al.   Journal of Thoracic Oncology

Loss of Menin Expression by Immunohistochemistry in Pancreatic Neuroendocrine Tumors

(2019) Rashmi T. Samdani et al.   PANCREAS

Giant Primary Neuroendocrine Neoplasms of the Liver: Report of 2 Cases With Molecular Characterization

(2019) Laura G. Pastrián et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

DNA methylation-based classification of sinonasal undifferentiated carcinoma

(2019) Snjezana Dogan et al.   MODERN PATHOLOGY

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

(2019) Thibault Kervarrec et al.   Frontiers in Oncology

The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

(2019) Todd C. Knepper et al.   CLINICAL CANCER RESEARCH

Two cases of lung neuroendocrine carcinoma with carcinoid morphology

(2019) Kenji Inafuku et al.   Diagnostic Pathology

Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system

(2019) Xiafei Hong et al.   GUT

Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals

(2019) Zhi-Jie Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation

(2019) Takeo Kosaka et al.   PATHOLOGY INTERNATIONAL

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

(2019) N. Alcala et al.   Nature Communications

IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management

(2019) Cristina Riobello et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile

(2019) B.C.M. Hermans et al.   LUNG CANCER

Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix

(2018) Deyin Xing et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Case of Gastric Neuroendocrine Neoplasm with Mixed Grade: a Distinct Type of “High”-grade Well-Differentiated Neuroendocrine Neoplasm

(2018) Elia Guadagno et al.   ENDOCRINE PATHOLOGY

A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix

(2018) Philip E. Castle et al.   GYNECOLOGIC ONCOLOGY

Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3

(2018) Björn Konukiewitz et al.   HUMAN PATHOLOGY

New Insights into the Molecular Characteristics of Pulmonary Carcinoids and Large Cell Neuroendocrine Carcinomas, and the Impact on Their Clinical Management

(2018) Jules L Derks et al.   Journal of Thoracic Oncology

Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm

(2018) Giuseppe Pelosi et al.   VIRCHOWS ARCHIV

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

(2018) Julie George et al.   Nature Communications

Grade 3 Neuroendocrine Tumor (G3 NET) in a Background of Multiple Serotonin Cell Neoplasms of the Ileum Associated with Carcinoid Syndrome and Aggressive Behavior

(2018) Francesca Capuano et al.   ENDOCRINE PATHOLOGY

Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinoma

(2018) Eliah R. Shamir et al.   MODERN PATHOLOGY

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

(2018) Guido Rindi et al.   MODERN PATHOLOGY

Clinicopathologic profiling of lung carcinoids with a Ki67 index greater than 20%

(2018) Atsuko Kasajima et al.   NEUROENDOCRINOLOGY

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

(2018) Chang S. Chan et al.   Nature Communications

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas

(2017) June-Koo Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas

(2017) María del Carmen González-Vela et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Towards personalised medicine in lung and thymus neuroendocrine tumours

(2017) Giuseppe Pelosi et al.   LANCET ONCOLOGY

Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study

(2017) Charles M Rudin et al.   LANCET ONCOLOGY

Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas

(2017) Moritz Jesinghaus et al.   MODERN PATHOLOGY

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Biology and evolution of poorly differentiated neuroendocrine tumors

(2017) David S Rickman et al.   NATURE MEDICINE

Thymic Neuroendocrine Neoplasms: Biological Behaviour and Therapy

(2017) Ru Jia et al.   NEUROENDOCRINOLOGY

Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift

(2017) Alessandra Fabbri et al.   VIRCHOWS ARCHIV

Distinctive pathological and clinical features of lung carcinoids with high proliferation index

(2017) Caterina Marchiò et al.   VIRCHOWS ARCHIV

A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas

(2016) Laura H. Tang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung

(2016) Brennan McCullar et al.   BREAST CANCER RESEARCH AND TREATMENT

Molecular profiling of neuroendocrine malignancies to identify prognostic and therapeutic markers: a Fox Chase Cancer Center Pilot Study

(2016) Namrata Vijayvergia et al.   BRITISH JOURNAL OF CANCER

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival

(2016) Joo Young Kim et al.   CLINICAL CANCER RESEARCH

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

(2016) Aatur D. Singhi et al.   CLINICAL CANCER RESEARCH

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets

(2016) N. Rekhtman et al.   CLINICAL CANCER RESEARCH

Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer

(2016) Julie George et al.   CLINICAL CANCER RESEARCH

Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes

(2016) Jarushka Naidoo et al.   Clinical Lung Cancer

Sporadic Gastric Well-Differentiated Neuroendocrine Tumors Have a Higher Ki-67 Proliferative Index

(2016) Hee Eun Lee et al.   ENDOCRINE PATHOLOGY

Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome

(2016) Yanli Li et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids

(2016) Sinju Sundaresan et al.   GUT

Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role forTERT,RB1,MEN1andKMT2D

(2016) Michele Simbolo et al.   JOURNAL OF PATHOLOGY

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components

(2016) Christine Woischke et al.   MODERN PATHOLOGY

The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories

(2016) Massimo Milione et al.   NEUROENDOCRINOLOGY

Four Neuroendocrine Tumor Types and Neuroendocrine Carcinoma of the Duodenum: Analysis of 203 Cases

(2016) Alessandro Vanoli et al.   NEUROENDOCRINOLOGY

p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas

(2016) Llucia Alos et al.   VIRCHOWS ARCHIV

The High-grade (WHO G3) Pancreatic Neuroendocrine Tumor Category Is Morphologically and Biologically Heterogenous and Includes Both Well Differentiated and Poorly Differentiated Neoplasms

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

(2015) Claudia Vollbrecht et al.   BRITISH JOURNAL OF CANCER

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

(2015) Paul William Harms et al.   CANCER RESEARCH

Characteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms

(2015) M Heetfeld et al.   ENDOCRINE-RELATED CANCER

Molecular characteristics of colorectal neuroendocrine carcinoma; similarities with adenocarcinoma rather than neuroendocrine tumor

(2015) Nobuyoshi Takizawa et al.   HUMAN PATHOLOGY

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

(2015) Lydia Meder et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer

(2015) Anna Karlsson et al.   Oncotarget

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy

(2015) Kei Mitsuhashi et al.   Oncotarget

Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity

(2014) Nora Sahnane et al.   ENDOCRINE-RELATED CANCER

Large cell neuroendocrine carcinoma of the head and neck: a distinct clinicopathologic entity

(2014) Alfio Ferlito et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Next-generation sequencing of salivary high-grade neuroendocrine carcinomas identifies alterations in RB1 and the mTOR pathway

(2014) Bella Goyal et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi-institutional clinicopathologic study

(2014) Philipp Ströbel et al.   GENES CHROMOSOMES & CANCER

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

(2014) JACOB Ø. RASMUSSEN et al.   ONCOLOGY REPORTS

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

(2014) A. Augustyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer

(2013) I. Canadas et al.   CLINICAL CANCER RESEARCH

Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

(2013) H.-L. Tan et al.   CLINICAL CANCER RESEARCH

Are G3 ENETS neuroendocrine neoplasms heterogeneous?

(2013) Fritz-Line Vélayoudom-Céphise et al.   ENDOCRINE-RELATED CANCER

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

Achaete-scute homolog 1 as a marker of poorly differentiated neuroendocrine carcinomas of different sites: a validation study using immunohistochemistry and quantitative real-time polymerase chain reaction on 335 cases

(2013) Stefano La Rosa et al.   HUMAN PATHOLOGY

Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma

(2013) S T Glenn et al.   ONCOGENE

Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors

(2012) Shinichi Yachida et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study

(2012) H. Sorbye et al.   ANNALS OF ONCOLOGY

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

(2012) Roeland F de Wilde et al.   MODERN PATHOLOGY

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells

(2012) S Kalari et al.   ONCOGENE

Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon–rectum

(2012) Daniela Furlan et al.   VIRCHOWS ARCHIV

Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

(2012) Lauren Averett Byers et al.   Cancer Discovery

Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms

(2011) Stefano La Rosa et al.   HUMAN PATHOLOGY

Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis

(2011) Anna Yemelyanova et al.   MODERN PATHOLOGY

ERG–TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin

(2011) Sean R Williamson et al.   MODERN PATHOLOGY

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases

(2010) Vincenzo Corbo et al.   ENDOCRINE-RELATED CANCER

Gene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome reveal novel molecular mechanism

(2009) Yu-fang Bi et al.   ENDOCRINE-RELATED CANCER

Primary Small Cell Neuroendocrine Carcinoma of the Kidney: Morphological, Immunohistochemical, Ultrastructural, and Cytogenetic Study of a Case and Review of the Literature

(2008) Stefano La Rosa et al.   ENDOCRINE PATHOLOGY

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE