High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms

PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer

(2020) Shailender S. Chauhan et al.   ONCOGENE

PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth

(2020) Neha Singh et al.   Molecular Oncology

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

(2019) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

Emerging Role of Eukaryote Ribosomes in Translational Control

(2019) Nicole Dalla Venezia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NEK2 Is an Effective Target for Cancer Therapy With Potential to Induce Regression of Multiple Human Malignancies

(2019) TOSHIO KOKURYO et al.   ANTICANCER RESEARCH

The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma

(2019) Marc S. Raab et al.   LEUKEMIA

Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology

(2019) Yuki Tenjin et al.   LABORATORY INVESTIGATION

NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling

(2019) Wei-Dong Fan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Current and future therapeutic approaches for the treatment of small cell lung cancer

(2018) Antonio Rossi et al.   Expert Review of Anticancer Therapy

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

(2018) Guido Rindi et al.   MODERN PATHOLOGY

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

PIM3 Functions as Oncogenic Factor and Promotes the Tumor Growth and Metastasis in Colorectal Cancer

(2018) Quan Qi et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway

(2018) Lianjing Cao et al.   CANCER LETTERS

Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors

(2017) Huaqiang Zhou et al.   GENE

Treatment advances in small cell lung cancer (SCLC)

(2017) Saiama N. Waqar et al.   PHARMACOLOGY & THERAPEUTICS

Management of pulmonary neuroendocrine tumors

(2017) Robert A. Ramirez et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Targeting NEK2 as a promising therapeutic approach for cancer treatment

(2016) Yanfen Fang et al.   CELL CYCLE

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

(2016) Fara Brasó-Maristany et al.   NATURE MEDICINE

Increased NEK2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting PP1/Akt and Wnt activation

(2016) Sailan Wen et al.   ONCOLOGY REPORTS

NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma

(2016) Shuang Lin et al.   ONCOLOGY REPORTS

Current understanding and approach to well differentiated lung neuroendocrine tumors: an update on classification and management

(2016) Talal Hilal   Therapeutic Advances in Medical Oncology

The 2015 World Health Organization Classification of Lung Tumors

(2015) William D. Travis et al.   Journal of Thoracic Oncology

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis

(2014) Xinwen Zhong et al.   TUMOR BIOLOGY

Differential expression of Pim-3, c-Myc, and p-p27 proteins in adenocarcinomas of the gastric cardia and distal stomach

(2014) Lei Lou et al.   TUMOR BIOLOGY

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers

(2013) Wen Zhou et al.   CANCER CELL

The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

(2013) C. Naro et al.   NUCLEIC ACIDS RESEARCH

Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma

(2013) Gholamreza Bidkhori et al.   PLoS One

Expression of pim-1 in Tumors, Tumor Stroma and Tumor-Adjacent Mucosa Co-Determines the Prognosis of Colon Cancer Patients

(2013) Yong-hai Peng et al.   PLoS One

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

The PIM kinases in hematological cancers

(2012) Yesid Alvarado et al.   Expert Review of Hematology

Roles of Pim-3, a novel survival kinase, in tumorigenesis

(2011) Naofumi Mukaida et al.   CANCER SCIENCE

The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

(2011) Methvin Isaac et al.   DRUG RESISTANCE UPDATES

Overexpression of Pim-1 in bladder cancer

(2011) Shengjie Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

(2010) Jongchan Kim et al.   BMC CANCER

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

(2008) Maria Teresa Landi et al.   PLoS One