Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function

Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns

(2014) Peter J. Castaldi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1

(2014) A. A. Oustah et al.   DEVELOPMENT

Ptch2 mediates the Shh response in Ptch1-/- cells

(2014) A. C. Alfaro et al.   DEVELOPMENT

Patched 1 and Patched 2 Redundancy Has a Key Role in Regulating Epidermal Differentiation

(2014) Christelle Adolphe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling

(2014) Lina Kwong et al.   Nature Communications

Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning

(2013) A. M. Holtz et al.   DEVELOPMENT

Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

(2013) Rochelle M. Witt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into proteoglycan-shaped Hedgehog signaling

(2013) D. M. Whalen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System

(2013) Murielle Saade et al.   Cell Reports

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling

(2012) K. L. Ayers et al.   DEVELOPMENT

Disruption of SoxB1-Dependent Sonic hedgehog Expression in the Hypothalamus Causes Septo-optic Dysplasia

(2012) Li Zhao et al.   DEVELOPMENTAL CELL

An Emerging Role of Sonic Hedgehog Shedding as a Modulator of Heparan Sulfate Interactions

(2012) Stefanie Ohlig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulfatase 1 Promotes the Motor Neuron-to-Oligodendrocyte Fate Switch by Activating Shh Signaling in Olig2 Progenitors of the Embryonic Ventral Spinal Cord

(2012) Y. Touahri et al.   JOURNAL OF NEUROSCIENCE

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

(2011) Benjamin L. Allen et al.   DEVELOPMENTAL CELL

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP

(2011) Xiaobo Zhou et al.   HUMAN MOLECULAR GENETICS

Importance of hedgehog interacting protein and other lung function genes in asthma

(2011) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Automation of large scale transient protein expression in mammalian cells

(2011) Yuguang Zhao et al.   JOURNAL OF STRUCTURAL BIOLOGY

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

(2011) Tomas Malinauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Chromosome 4q31 locus in COPD is also associated with lung cancer

(2010) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study

(2009) Y. M. T. A. Van Durme et al.   EUROPEAN RESPIRATORY JOURNAL

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Neuroepithelial Sonic hedgehog in Hypothalamic Patterning

(2009) N.-E. Szabo et al.   JOURNAL OF NEUROSCIENCE

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

(2009) Jennifer A Chan et al.   NATURE NEUROSCIENCE

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

(2009) Benjamin Bishop et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

(2009) Ivan Bosanac et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure prediction for CASP8 with all-atom refinement using Rosetta

(2009) Srivatsan Raman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Shaping Morphogen Gradients by Proteoglycans

(2009) D. Yan et al.   Cold Spring Harbor Perspectives in Biology

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway

(2008) Marco J Koudijs et al.   BMC DEVELOPMENTAL BIOLOGY

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT