Recent advances in genetic manipulation of Cryptosporidium

A Conditional Protein Degradation System To Study Essential Gene Function in Cryptosporidium parvum

(2020) Hadi H. Choudhary et al.   mBio

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

(2019) Beatriz Baragaña et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piperazine-Derivative MMV665917: an effective drug in the diarrheic piglet model of Cryptosporidium hominis

(2019) Sangun Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

(2019) Frederick S. Buckner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS)

(2019) Karen L Kotloff et al.   Lancet Global Health

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability

(2019) Georgia Wilke et al.   Cell Host & Microbe

A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity

(2019) Adam Sateriale et al.   Cell Host & Microbe

Cryptosporidiosis Outbreaks — United States, 2009–2017

(2019) Radhika Gharpure et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

(2019) Mattie C. Pawlowic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

(2019) Jayesh Tandel et al.   Nature Microbiology

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

(2019) Christopher Swale et al.   Science Translational Medicine

Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis

(2018) Sangun Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New and emerging uses of CRISPR/Cas9 to genetically manipulate apicomplexan parasites

(2018) Manlio Di Cristina et al.   PARASITOLOGY

Cryopreservation of infectious Cryptosporidium parvum oocysts

(2018) Justyna J. Jaskiewicz et al.   Nature Communications

Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study

(2018) Ibrahim A Khalil et al.   Lancet Global Health

Outbreaks Associated with Treated Recreational Water — United States, 2000–2014

(2018) Michele C. Hlavsa et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Widespread occurrence of Cryptosporidium infections in patients with HIV/AIDS: Epidemiology, clinical feature, diagnosis, and therapy

(2018) Rong-jun Wang et al.   ACTA TROPICA

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis

(2018) Sangun Lee et al.   Human Vaccines & Immunotherapeutics

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum

(2018) Kelly M. Hennessey et al.   PLoS Neglected Tropical Diseases

Advances in the application of genetic manipulation methods to apicomplexan parasites

(2017) C.E. Suarez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

(2017) Samuel L. M. Arnold et al.   JOURNAL OF INFECTIOUS DISEASES

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

(2017) Matthew A. Hulverson et al.   JOURNAL OF INFECTIOUS DISEASES

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

(2017) Ujjini H. Manjunatha et al.   NATURE

Cryptosporidium spp. Infection in Solid Organ Transplantation

(2017) Fanny Lanternier et al.   TRANSPLANTATION

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

(2017) Melissa S. Love et al.   PLoS Neglected Tropical Diseases

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Continuous culture of Cryptosporidium parvum using hollow fiber technology

(2016) Mary Morada et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Genome Editing by CRISPR/Cas9: A Game Change in the Genetic Manipulation of Protists

(2016) Noelia Lander et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

(2016) Li Liu et al.   LANCET

Cryptosporidiosis Drug Discovery: Opportunities and Challenges

(2016) Ujjini H. Manjunatha et al.   ACS Infectious Diseases

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Parasitology: CRISPR for Cryptosporidium

(2015) Stephen M. Beverley   NATURE

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

C. parvum gets the CRISPR upgrade

(2015) Elizabeth Zuccala   NATURE REVIEWS GENETICS

Cryptosporidium: a first step toward tractability

(2015) Lizbeth Hedstrom   TRENDS IN PARASITOLOGY

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9

(2014) Saima M. Sidik et al.   PLoS One

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Estimates of Enteric Illness Attributable to Contact With Animals and Their Environments in the United States

(2012) Christa R. Hale et al.   CLINICAL INFECTIOUS DISEASES

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Cryptosporidiosis in patients with HIV/AIDS

(2010) Roberta M OʼConnor et al.   AIDS

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

(2010) Mari Iwamoto et al.   CHEMISTRY & BIOLOGY

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

(2010) Lisa Sharling et al.   PLoS Neglected Tropical Diseases

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES