A Conditional Protein Degradation System To Study Essential Gene Function in Cryptosporidium parvum

A One Health Approach to Tackle Cryptosporidiosis

(2020) Elisabeth A. Innes et al.   TRENDS IN PARASITOLOGY

Defining Stage-Specific Activity of Potent New Inhibitors of Cryptosporidium parvum Growth In Vitro

(2020) Lisa J. Funkhouser-Jones et al.   mBio

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

(2020) Ryan Choi et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

(2020) Malgorzata Broncel et al.   eLife

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

(2019) Beatriz Baragaña et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability

(2019) Georgia Wilke et al.   Cell Host & Microbe

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

(2019) Christopher S. Lunde et al.   Nature Communications

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

(2019) Mattie C. Pawlowic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

(2019) Jayesh Tandel et al.   Nature Microbiology

The Existing Drug Vorinostat as a New Lead Against Cryptosporidiosis by Targeting the Parasite Histone Deacetylases

(2018) Fengguang Guo et al.   JOURNAL OF INFECTIOUS DISEASES

Context-dependent expression of a conditionally-inducible form of active Akt

(2018) Soyeon Park et al.   PLoS One

Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study

(2018) Ibrahim A Khalil et al.   Lancet Global Health

Outbreaks Associated with Treated Recreational Water — United States, 2000–2014

(2018) Michele C. Hlavsa et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro

(2018) Georgia Wilke et al.   mSphere

Widespread occurrence of Cryptosporidium infections in patients with HIV/AIDS: Epidemiology, clinical feature, diagnosis, and therapy

(2018) Rong-jun Wang et al.   ACTA TROPICA

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

(2017) Matthew A. Hulverson et al.   JOURNAL OF INFECTIOUS DISEASES

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

(2017) Ujjini H. Manjunatha et al.   NATURE

Cryptosporidium spp. Infection in Solid Organ Transplantation

(2017) Fanny Lanternier et al.   TRANSPLANTATION

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

(2017) Kevin M. Brown et al.   mBio

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

(2017) Melissa S. Love et al.   PLoS Neglected Tropical Diseases

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis

(2016) Deborah A. Schaefer et al.   JOURNAL OF INFECTIOUS DISEASES

Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector

(2015) Nisha Philip et al.   Cell Host & Microbe

Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans

(2015) Aditya S. Paul et al.   Cell Host & Microbe

Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease

(2015) Erik Cederfjäll et al.   MOLECULAR THERAPY

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

Advances in molecular genetic systems in malaria

(2015) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Destabilization domain approach adapted for regulated protein expression in the protozoan parasite Entamoeba histolytica

(2014) Yuk-Chien Liu et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

CDPKs of Cryptosporidium parvum—stage-specific expression in vitro

(2014) Manja Etzold et al.   PARASITOLOGY RESEARCH

A novel CDPK1 inhibitor—a potential treatment for cryptosporidiosis in calves?

(2014) Matthias Lendner et al.   PARASITOLOGY RESEARCH

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium yoeliiinhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development

(2013) Ying Pei et al.   CELLULAR MICROBIOLOGY

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

(2013) Kayode K. Ojo et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Functional Neuroprotection and Efficient Regulation of GDNF Using Destabilizing Domains in a Rodent Model of Parkinson’s Disease

(2013) Luis Quintino et al.   MOLECULAR THERAPY

Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme

(2013) Parichat Prommana et al.   PLoS One

Waterborne outbreaks of cryptosporidiosis

(2013) Rachel M. Chalmers   ANNALI DELL ISTITUTO SUPERIORE DI SANITA

A Tetracycline-Repressible Transactivator System to Study Essential Genes in Malaria Parasites

(2012) Paco Pino et al.   Cell Host & Microbe

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

(2012) Kayode K. Ojo et al.   JOURNAL OF CLINICAL INVESTIGATION

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

(2012) Erin Garrison et al.   PLoS Pathogens

TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells

(2012) James M. McCoy et al.   PLoS Pathogens

A method for rapid regulation of protein expression in Trypanosoma cruzi

(2011) Yan Fen Ma et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag

(2011) V. Muralidharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptosporidiosis in patients with HIV/AIDS

(2010) Roberta M OʼConnor et al.   AIDS

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

(2010) Mari Iwamoto et al.   CHEMISTRY & BIOLOGY

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES

Towards New Antifolates Targeting Eukaryotic Opportunistic Infections

(2009) Jieying Liu et al.   EUKARYOTIC CELL