Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease

Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease

(2020) Peng Yang et al.   BIOMATERIALS

Synaptic plasticity in Alzheimer’s disease and healthy aging

(2020) Diana Marcela Cuestas Torres et al.   REVIEWS IN THE NEUROSCIENCES

Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

(2020) Claudia P. Boix et al.   Alzheimers Research & Therapy

Ca2+ homeostasis dysregulation in Alzheimer’s disease: a focus on plasma membrane and cell organelles

(2019) Xingjian Wang et al.   FASEB JOURNAL

Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer’s disease

(2019) Xiangqing Li et al.   CYTOTECHNOLOGY

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Therapeutics for dementia and Alzheimer's disease: New directions for precision medicine

(2019) J.A. Duce et al.   BRITISH JOURNAL OF PHARMACOLOGY

Changes in Ca2+ Removal Can Mask the Effects of Geometry During IP3R Mediated Ca2+ Signals

(2019) Estefanía Piegari et al.   Frontiers in Physiology

Selective autophagy: The new player in the fight against neurodegenerative diseases?

(2018) Ming-Yue Wu et al.   BRAIN RESEARCH BULLETIN

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

(2018) Bernadette Schreiner et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of Endoplasmic Reticulum-Mitochondria contacts by Parkin via Mfn2

(2018) Valentina Basso et al.   PHARMACOLOGICAL RESEARCH

p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity

(2018) Asad Lone et al.   Scientific Reports

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

(2017) Jędrzej Szymański et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

(2017) Vijendra Sharma et al.   JOURNAL OF NEUROSCIENCE

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

(2017) M. Isabel G. Lopez Sanchez et al.   Scientific Reports

Mitochondria-associated membranes as hubs for neurodegeneration

(2016) Michiel Krols et al.   ACTA NEUROPATHOLOGICA

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1 ‐ and SOD1 ‐linked ALS

(2016) Seiji Watanabe et al.   EMBO Molecular Medicine

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

(2016) Radu Stoica et al.   EMBO REPORTS

Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex

(2016) S.A. Neymotin et al.   NEUROSCIENCE

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Tau: The Center of a Signaling Nexus in Alzheimer's Disease

(2016) Shahzad S. Khan et al.   Frontiers in Neuroscience

A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction

(2016) Michael A. Kennedy et al.   Scientific Reports

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

(2015) Matthew Baumgart et al.   Alzheimers & Dementia

Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes

(2015) Toni Gabaldón et al.   BIOCHIMIE

Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer’s disease: A review on experimental progress and computational modeling

(2015) Jingyi Liang et al.   BIOSYSTEMS

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle

(2015) Alina Ainbinder et al.   CELL CALCIUM

ApoE4 upregulates the activity of mitochondria-associated ER membranes

(2015) M. D. Tambini et al.   EMBO REPORTS

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

(2015) Yohei Shibuya et al.   NEUROBIOLOGY OF AGING

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

(2014) Manoj Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance

(2014) Y. Shibuya et al.   JOURNAL OF NEUROSCIENCE

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ceramide and the mitochondrial respiratory chain

(2013) Aviram Kogot-Levin et al.   BIOCHIMIE

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

(2013) Irina Lonskaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Transport between the Endoplasmic Reticulum and Mitochondria

(2013) V. V. Flis et al.   Cold Spring Harbor Perspectives in Biology

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease

(2013) Elena Popugaeva et al.   Frontiers in Molecular Neuroscience

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

(2012) Marta Pera et al.   ACTA NEUROPATHOLOGICA

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure

(2012) S Dinkla et al.   Cell Death & Disease

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Quantitative Proteomic Analyses of Human Cytomegalovirus-Induced Restructuring of Endoplasmic Reticulum-Mitochondrial Contacts at Late Times of Infection

(2011) Aiping Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

(2011) Gary E. Gibson et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

(2011) Randall J Bateman et al.   Alzheimers Research & Therapy

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

(2010) Olga Martins de Brito et al.   EMBO JOURNAL

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

Fusion of the Endoplasmic Reticulum and Mitochondrial Outer Membrane in Rats Brown Adipose Tissue: Activation of Thermogenesis by Ca2+

(2010) Leopoldo de Meis et al.   PLoS One

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cholesterol in Alzheimers Disease: Unresolved Questions

(2009) Massimo Stefani et al.   Current Alzheimer Research

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

(2009) Hedvig Welander et al.   JOURNAL OF NEUROCHEMISTRY

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Physical Coupling Supports the Local Ca2+Transfer between Sarcoplasmic Reticulum Subdomains and the Mitochondria in Heart Muscle

(2008) Cecilia García-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

(2008) Dong-Gyu Jo et al.   NEUROBIOLOGY OF AGING

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES