ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells

(2019) Lu Liu et al.   NATURE CELL BIOLOGY

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

(2019) Cindy T.J. van Velthoven et al.   Cell Stem Cell

Weak membrane interactions allow rheb to activate mTORC1 signaling without major lysosome enrichment

(2019) Brittany Angarola et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

(2018) Christian Chabannon et al.   Science Translational Medicine

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

(2018) Sarah J. Mahoney et al.   Nature Communications

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

(2018) Asmita Bhattacharya et al.   EMBO JOURNAL

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

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Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

(2016) Victoria Zismanov et al.   Cell Stem Cell

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

(2016) Shengyi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

(2016) Nicola Vannini et al.   Nature Communications

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

(2016) Yuanming Xu et al.   Nature Communications

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

(2016) Yewei Ji et al.   Cell Reports

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(2015) Shengyi Sun et al.   NATURE CELL BIOLOGY

Cellular Differences in Protein Synthesis Regulate Tissue Homeostasis

(2014) Michael Buszczak et al.   CELL

The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism

(2014) Haibo Sha et al.   Cell Metabolism

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus

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Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

(2013) Qing Li et al.   NATURE

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

Maintenance of muscle stem-cell quiescence by microRNA-489

(2012) Tom H. Cheung et al.   NATURE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

(2011) Christopher R.R. Bjornson et al.   STEM CELLS

Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality

(2010) Adam B. Francisco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity

(2008) M. J. Kiel et al.   BLOOD

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY