- Home
- Publications
- Publication Search
- Publication Details
Title
Understanding gradients in industrial bioreactors
Authors
Keywords
Bioreactor, Gradients, Scale-down, Computational Fluid Dynamics (CFD), Compartment model, Scale-up, Sensor particles, Microbial physiology, Kinetic modelling, Industrial fermentation processes
Journal
BIOTECHNOLOGY ADVANCES
Volume 46, Issue -, Pages 107660
Publisher
Elsevier BV
Online
2020-11-20
DOI
10.1016/j.biotechadv.2020.107660
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- An Industrial Perspective on Scale-Down Challenges Using Miniaturized Bioreactors
- (2019) Tannaz Tajsoleiman et al. TRENDS IN BIOTECHNOLOGY
- Measurements on the fly– Introducing mobile micro-sensors for biotechnological applications
- (2019) Tim Lauterbach et al. SENSORS AND ACTUATORS A-PHYSICAL
- Grand Research Challenges for Sustainable Industrial Biotechnology
- (2019) Adrie J.J. Straathof et al. TRENDS IN BIOTECHNOLOGY
- A Compartment Model for Risk-Based Monitoring of Lactic Acid Bacteria Cultivations
- (2019) Robert Spann et al. BIOCHEMICAL ENGINEERING JOURNAL
- Physiological responses of Saccharomyces cerevisiae to industrially relevant conditions: slow growth, low pH and high CO 2 levels
- (2019) Xavier Hakkaart et al. BIOTECHNOLOGY AND BIOENGINEERING
- The impact of CO gradients on C. ljungdahlii in a 125 m3 bubble column: Mass transfer, circulation time and lifeline analysis
- (2019) Flora Siebler et al. CHEMICAL ENGINEERING SCIENCE
- Scale‐down studies for the scale‐up of a recombinant Corynebacterium glutamicum fed‐batch fermentation: loss of homogeneity leads to lower levels of cadaverine production
- (2019) Williams Olughu et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Compartmental Modelling in chemical engineering: A critical review
- (2019) Nicolas Jourdan et al. CHEMICAL ENGINEERING SCIENCE
- Importance of the cultivation history for the response of Escherichia coli to oscillations in scale-down experiments
- (2018) Eva Brand et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Population heterogeneity in microbial bioprocesses: origin, analysis, mechanisms, and future perspectives
- (2018) Anna-Lena Heins et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Oxygen transfer in pilot-scale contactors: An experimental and computational investigation into the effect of contactor design
- (2018) Dale D. McClure et al. CHEMICAL ENGINEERING JOURNAL
- Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization
- (2018) Cees Haringa et al. CHEMICAL ENGINEERING SCIENCE
- Real-time monitoring of the budding index in Saccharomyces cerevisiae batch cultivations with in situ microscopy
- (2018) Anna-Maria Marbà-Ardébol et al. Microbial Cell Factories
- Comparative performance of different scale-down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis
- (2018) Guan Wang et al. Microbial Biotechnology
- Modelling concentration gradients in fed-batch cultivations of E. coli - towards the flexible design of scale-down experiments
- (2018) Emmanuel Anane et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition
- (2018) Hongzhong Lu et al. Scientific Reports
- CFD predicted pH gradients in lactic acid bacteria cultivations
- (2018) Robert Spann et al. BIOTECHNOLOGY AND BIOENGINEERING
- Hypothesis-driven compartment model for stirred bioreactors utilizing computational fluid dynamics and multiple pH sensors
- (2018) Anders Nørregaard et al. CHEMICAL ENGINEERING JOURNAL
- A CFD based automatic method for compartment model development
- (2018) Tannaz Tajsoleiman et al. COMPUTERS & CHEMICAL ENGINEERING
- Elevated pCO2 affects the lactate metabolic shift in CHO cell culture processes
- (2017) Matthias Brunner et al. ENGINEERING IN LIFE SCIENCES
- Spatial monitoring of the liquid phase with multiparameter sensors in industrial-scale fermenters
- (2017) Ute Enseleit et al. tm-Technisches Messen
- Sterol synthesis and cell size distribution under oscillatory growth conditions in Saccharomyces cerevisiae scale-down cultivations
- (2017) Anna-Maria Marbà-Ardébol et al. YEAST
- The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion
- (2017) Matthias Brunner et al. Biotechnology Journal
- Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model
- (2017) Alexander Nieß et al. Frontiers in Microbiology
- Why Do Fast-Growing Bacteria Enter Overflow Metabolism? Testing the Membrane Real Estate Hypothesis
- (2017) Mariola Szenk et al. Cell Systems
- Transcriptional response of Escherichia coli to ammonia and glucose fluctuations
- (2017) Joana Danica Simen et al. Microbial Biotechnology
- Metabolic profile of 1,5-diaminopentane producing Corynebacterium glutamicum under scale-down conditions: Blueprint for robustness to bioreactor inhomogeneities
- (2016) Michael H. Limberg et al. BIOTECHNOLOGY AND BIOENGINEERING
- Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess
- (2016) Yuanwei Gao et al. Biotechnology Journal
- Characterizing bubble column bioreactor performance using computational fluid dynamics
- (2016) Dale D. McClure et al. CHEMICAL ENGINEERING SCIENCE
- Plug flow versus stirred tank reactor flow characteristics in two-compartment scale-down bioreactor: Setup-specific influence on the metabolic phenotype and bioprocess performance ofCorynebacterium glutamicum
- (2016) Michael H. Limberg et al. ENGINEERING IN LIFE SCIENCES
- Performance loss ofCorynebacterium glutamicumcultivations under scale-down conditions using complex media
- (2016) Anja Lemoine et al. ENGINEERING IN LIFE SCIENCES
- Euler-Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines
- (2016) Cees Haringa et al. ENGINEERING IN LIFE SCIENCES
- Engineering E. coli for large-scale production – Strategies considering ATP expenses and transcriptional responses
- (2016) Michael Löffler et al. METABOLIC ENGINEERING
- Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess
- (2016) Yuanwei Gao et al. Biotechnology Journal
- Physiological effects of pH gradients onEscherichia coliduring plasmid DNA production
- (2015) José T. Cortés et al. BIOTECHNOLOGY AND BIOENGINEERING
- Response ofCorynebacterium glutamicumexposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor
- (2015) Anja Lemoine et al. BIOTECHNOLOGY AND BIOENGINEERING
- Environmental stress speeds up DNA replication in Pseudomonas putida in chemostat cultivations
- (2015) Sarah Lieder et al. Biotechnology Journal
- Oxygen transfer in bubble columns at industrially relevant superficial velocities: Experimental work and CFD modelling
- (2015) Dale D. McClure et al. CHEMICAL ENGINEERING JOURNAL
- Mixing in bubble column reactors: Experimental study and CFD modeling
- (2015) Dale D. McClure et al. CHEMICAL ENGINEERING JOURNAL
- Towards a CFD model of bubble columns containing significant surfactant levels
- (2015) Dale D. McClure et al. CHEMICAL ENGINEERING SCIENCE
- Investigating the interactions between physical and biological heterogeneities in bioreactors using compartment, population balance and metabolic models
- (2015) Maxime Pigou et al. CHEMICAL ENGINEERING SCIENCE
- Autonomous Sensor Capsule for Usage in Bioreactors
- (2015) Nicole Todtenberg et al. IEEE SENSORS JOURNAL
- Euler-Lagrange CFD modelling of unconfined gas mixing in anaerobic digestion
- (2015) Davide Dapelo et al. WATER RESEARCH
- Environmental stress speeds up DNA replication in Pseudomonas putida in chemostat cultivations
- (2015) Sarah Lieder et al. Biotechnology Journal
- CO2/HCO3 − perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum
- (2014) Jens Buchholz et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Scale-down effect on the extracellular proteome of Escherichia coli: correlation with membrane permeability and modulation according to substrate heterogeneities
- (2014) Alison Brognaux et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Impact of Surfactant Addition on Oxygen Mass Transfer in a Bubble Column
- (2014) Dale D. McClure et al. CHEMICAL ENGINEERING & TECHNOLOGY
- Impact of Surfactant Chemistry on Bubble Column Systems
- (2014) Dale D. McClure et al. CHEMICAL ENGINEERING & TECHNOLOGY
- Importance of scale and hydrodynamics for modeling anaerobic digester performance
- (2014) Stijn W.H. Van Hulle et al. CHEMICAL ENGINEERING JOURNAL
- Experimental andin silicoinvestigation of population heterogeneity in continuousSachharomyces cerevisiaescale-down fermentation in a two-compartment setup
- (2014) Anna-Lena Heins et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum
- (2014) Friedrich Käß et al. Microbial Cell Factories
- A coupled population balance model and CFD approach for the simulation of mixing issues in lab-scale and industrial bioreactors
- (2013) Jérôme Morchain et al. AICHE JOURNAL
- Dynamic pH model for autotrophic growth of microalgae in photobioreactor: A tool for monitoring and control purposes
- (2013) George A. Ifrim et al. AICHE JOURNAL
- Assessment of robustness against dissolved oxygen/substrate oscillations for C. glutamicum DM1933 in two-compartment bioreactor
- (2013) Friedrich Käß et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Flux response of glycolysis and storage metabolism during rapid feast/famine conditions inPenicillium chrysogenumusing dynamic13C labeling
- (2013) Lodewijk de Jonge et al. Biotechnology Journal
- Compartmental modelling of turbulent fluid flow for the scale-up of stirred tanks
- (2013) Hamed Bashiri et al. CANADIAN JOURNAL OF CHEMICAL ENGINEERING
- Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture
- (2013) Alvin W. Nienow et al. CHEMICAL ENGINEERING RESEARCH & DESIGN
- CFD-based compartment model for description of mixing in bioreactors
- (2013) Angélique Delafosse et al. CHEMICAL ENGINEERING SCIENCE
- Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut+ strain using a two-compartment scale-down system
- (2013) Bettina Lorantfy et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Evaluating evolutionary models of stress-induced mutagenesis in bacteria
- (2013) R. Craig MacLean et al. NATURE REVIEWS GENETICS
- Coupling of biokinetic and population balance models to account for biological heterogeneity in bioreactors
- (2012) Jérôme Morchain et al. AICHE JOURNAL
- Comparison of the transient responses of Escherichia coli to a glucose pulse of various intensities
- (2012) Sirichai Sunya et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Flow following sensor particles—Validation and macro-mixing analysis in a stirred fermentation vessel with a highly viscous substrate
- (2012) S. Reinecke et al. BIOCHEMICAL ENGINEERING JOURNAL
- Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions-targeted precursor feeding designed from metabolomics
- (2012) Claudia Korneli et al. BIOTECHNOLOGY AND BIOENGINEERING
- Metabolic shifts: a fitness perspective for microbial cell factories
- (2012) Anisha Goel et al. BIOTECHNOLOGY LETTERS
- Experimental methods and modeling techniques for description of cell population heterogeneity
- (2011) R. Lencastre Fernandes et al. BIOTECHNOLOGY ADVANCES
- Modeling enzyme production with Aspergillus oryzae in pilot scale vessels with different agitation, aeration, and agitator types
- (2011) Mads O. Albaek et al. BIOTECHNOLOGY AND BIOENGINEERING
- Simulation of dissolved CO2 gradients in a scale-down system: A metabolic and transcriptional study of recombinant Escherichia coli
- (2011) Antonino Baez et al. Biotechnology Journal
- A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: Impact of oscillations on Bacillus subtilis fed-batch cultivations
- (2011) Stefan Junne et al. Biotechnology Journal
- An industrial perspective on bioreactor scale-down: What we can learn from combined large-scale bioprocess and model fluid studies
- (2011) Henk Noorman Biotechnology Journal
- Scale-down of penicillin production in Penicillium chrysogenum
- (2011) Lodewijk P. de Jonge et al. Biotechnology Journal
- Effect of tank size on kLa and mixing time in aerated stirred reactors with non-newtonian fluids
- (2011) J.-C. Gabelle et al. CANADIAN JOURNAL OF CHEMICAL ENGINEERING
- Application of computational fluid dynamics for modeling and designing photobioreactors for microalgae production: A review
- (2011) J.P. Bitog et al. COMPUTERS AND ELECTRONICS IN AGRICULTURE
- Influence of fructose and oxygen gradients on fed-batch recombinant protein production using Bacillus megaterium
- (2011) Claudia Korneli et al. ENGINEERING IN LIFE SCIENCES
- Scale-down assessment of the sensitivity of Yarrowia lipolytica to oxygen transfer and foam management in bioreactors: investigation of the underlying physiological mechanisms
- (2011) Tambi Kar et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Escherichia coli responds with a rapid and large change in growth rate upon a shift from glucose-limited to glucose-excess conditions
- (2011) Hilal Taymaz-Nikerel et al. METABOLIC ENGINEERING
- Scale-down simulators for metabolic analysis of large-scale bioprocesses
- (2010) Peter Neubauer et al. CURRENT OPINION IN BIOTECHNOLOGY
- Use of genome-scale metabolic models for understanding microbial physiology
- (2010) Liming Liu et al. FEBS LETTERS
- Autonomous sensor particle for parameter tracking in large vessels
- (2010) Sebastian Thiele et al. MEASUREMENT SCIENCE and TECHNOLOGY
- Application of mechanistic models to fermentation and biocatalysis for next-generation processes
- (2010) Krist V. Gernaey et al. TRENDS IN BIOTECHNOLOGY
- Rapid sampling devices for metabolic engineering applications
- (2009) Friederike Schädel et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Influence of bioreactor hydraulic characteristics on a Saccharomyces cerevisiae fed-batch culture: hydrodynamic modelling and scale-down investigations
- (2009) Annick Lejeune et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview
- (2008) Felix Garcia-Ochoa et al. BIOTECHNOLOGY ADVANCES
- CFD simulation of bubble column—An analysis of interphase forces and turbulence models
- (2007) Mandar V. Tabib et al. CHEMICAL ENGINEERING JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More