Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess

The use of ‘Omics technology to rationally improve industrial mammalian cell line performance

(2015) Amanda M. Lewis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

(2015) Christopher A. Sellick et al.   Biotechnology Journal

Efficient high-throughput biological process characterization: Definitive screening design with the Ambr250 bioreactor system

(2015) Mitchell Tai et al.   BIOTECHNOLOGY PROGRESS

Elucidating the role of copper in CHO cell energy metabolism using13C metabolic flux analysis

(2015) Shilpa Nargund et al.   BIOTECHNOLOGY PROGRESS

Engineered CHO cells for production of diverse, homogeneous glycoproteins

(2015) Zhang Yang et al.   NATURE BIOTECHNOLOGY

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

(2015) Christopher A. Sellick et al.   Biotechnology Journal

Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation

(2014) Vladislav V. Makarenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks

(2014) Yueming Qian et al.   Biotechnology Journal

Effects of copper on CHO cells: Cellular requirements and product quality considerations

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Insights from gene expression analyses

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Copper as a key regulator of cell signalling pathways

(2014) Alexandra Grubman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Proteomics analysis of altered cellular metabolism induced by insufficient copper level

(2014) Sohye Kang et al.   JOURNAL OF BIOTECHNOLOGY

MS Amanda, a Universal Identification Algorithm Optimized for High Accuracy Tandem Mass Spectra

(2014) Viktoria Dorfer et al.   JOURNAL OF PROTEOME RESEARCH

Application of Multi-Omics Techniques for Bioprocess Design and Optimization in Chinese Hamster Ovary Cells

(2014) Amy Farrell et al.   JOURNAL OF PROTEOME RESEARCH

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

(2013) Helene Faustrup Kildegaard et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

(2013) Nathan E Lewis et al.   NATURE BIOTECHNOLOGY

Oleic, Linoleic and Linolenic Acids Increase ROS Production by Fibroblasts via NADPH Oxidase Activation

(2013) Elaine Hatanaka et al.   PLoS One

DanteR: an extensible R-based tool for quantitative analysis of -omics data

(2012) Tom Taverner et al.   BIOINFORMATICS

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains

(2011) Cristiane L. Dalla Corte et al.   BRAIN RESEARCH

Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

(2011) Xiuli Lu et al.   CELL STRESS & CHAPERONES

Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

(2011) Jun Shirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR-based metabolomics of mammalian cell and tissue cultures

(2011) Nelly Aranibar et al.   JOURNAL OF BIOMOLECULAR NMR

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Proteomics: a pragmatic perspective

(2010) Parag Mallick et al.   NATURE BIOTECHNOLOGY

Emerging links between CDK cell cycle regulators and Wnt signaling

(2010) Gary Davidson et al.   TRENDS IN CELL BIOLOGY

Superoxide dismutases—a review of the metal-associated mechanistic variations

(2009) Isabel A. Abreu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reactive species and diabetes: counteracting oxidative stress to improve health

(2009) Patricia Pérez-Matute et al.   CURRENT OPINION IN PHARMACOLOGY

Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link

(2009) L. Lavie et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Analysis of the adult human plasma metabolome

(2008) Kay A Lawton et al.   PHARMACOGENOMICS

Upstream processes in antibody production: Evaluation of critical parameters

(2007) Era Jain et al.   BIOTECHNOLOGY ADVANCES