The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down modelling and intracellular pH excursion

Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

(2016) Matthias Brunner et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Plug flow versus stirred tank reactor flow characteristics in two-compartment scale-down bioreactor: Setup-specific influence on the metabolic phenotype and bioprocess performance ofCorynebacterium glutamicum

(2016) Michael H. Limberg et al.   ENGINEERING IN LIFE SCIENCES

Physiological effects of pH gradients onEscherichia coliduring plasmid DNA production

(2015) José T. Cortés et al.   BIOTECHNOLOGY AND BIOENGINEERING

Response ofCorynebacterium glutamicumexposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor

(2015) Anja Lemoine et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process

(2015) Dénes Zalai et al.   BIOTECHNOLOGY PROGRESS

Multiposition Sensor Technology and Lance-Based Sampling for Improved Monitoring of the Liquid Phase in Biogas Processes

(2015) Erich Kielhorn et al.   ENERGY & FUELS

CO2/HCO3 − perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum

(2014) Jens Buchholz et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

In Situ Investigation of the Liquid Phase in Industrial Yeast Fermentations with Mobile Multiparameter Sensors

(2014) A. Bockisch et al.   CHEMIE INGENIEUR TECHNIK

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

ETA: Robust software for determination of cell specific rates from extracellular time courses

(2013) Taylor A. Murphy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

(2013) Alvin W. Nienow et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Characterizing flows with an instrumented particle measuring Lagrangian accelerations

(2013) Robert Zimmermann et al.   NEW JOURNAL OF PHYSICS

Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture

(2012) Laura A Bailey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single-Use Pumps

(2012) Katharina Blaschczok et al.   CHEMIE INGENIEUR TECHNIK

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An industrial perspective on bioreactor scale-down: What we can learn from combined large-scale bioprocess and model fluid studies

(2011) Henk Noorman   Biotechnology Journal

The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding

(2011) Weiwei Hu et al.   CYTOTECHNOLOGY

Validation of cell density and viability assays using Cedex automated cell counter

(2010) Li-Chun Huang et al.   BIOLOGICALS

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS