Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors
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Title
Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors
Authors
Keywords
Phenstatin based indole-linked chalcones, In vitro, cell cytotoxicity, Cancer stem- like cells, Spheroid assay, Oral cancer xenograft model, PET-CT imaging, F-fluorodeoxyglucose uptake, Glucose metabolism, In silico, analysis, Molecular docking, Tubulin polymerization inhibition, Surface Plasmon Resonance, Multi-target metabolic inhibitor, Anti-cancer efficacy, Immunofluorescence, Laser confocal microscopy, Transmission electron microscopy
Journal
BIOORGANIC CHEMISTRY
Volume 105, Issue -, Pages 104447
Publisher
Elsevier BV
Online
2020-11-01
DOI
10.1016/j.bioorg.2020.104447
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