Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors

Title
Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors
Authors
Keywords
Phenstatin based indole-linked chalcones, In vitro, cell cytotoxicity, Cancer stem- like cells, Spheroid assay, Oral cancer xenograft model, PET-CT imaging, F-fluorodeoxyglucose uptake, Glucose metabolism, In silico, analysis, Molecular docking, Tubulin polymerization inhibition, Surface Plasmon Resonance, Multi-target metabolic inhibitor, Anti-cancer efficacy, Immunofluorescence, Laser confocal microscopy, Transmission electron microscopy
Journal
BIOORGANIC CHEMISTRY
Volume 105, Issue -, Pages 104447
Publisher
Elsevier BV
Online
2020-11-01
DOI
10.1016/j.bioorg.2020.104447

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