Donor‐derived regulatory dendritic cell infusion results in host cell cross‐dressing and T cell subset changes in prospective living donor liver transplant recipients

Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection

(2020) Muthukumar Gunasekaran et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Natural and Induced Tolerogenic Dendritic Cells

(2020) Courtney A. Iberg et al.   JOURNAL OF IMMUNOLOGY

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Preclinical assessment of Autologous Tolerogenic Dendritic Cells from End-stage renal disease patients

(2020) Laurence Bouchet-Delbos et al.   TRANSPLANTATION

Impact of donor extracellular vesicle release on recipient cell “cross‐dressing” following clinical liver and kidney transplantation

(2020) Sotiris Mastoridis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Understanding, predicting and achieving liver transplant tolerance: from bench to bedside

(2020) Angus W. Thomson et al.   Nature Reviews Gastroenterology & Hepatology

Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity

(2020) Laura Antonucci et al.   Journal of Immunology Research

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

(2019) Irati Zubizarreta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory dendritic cells for human organ transplantation

(2019) Angus W. Thomson et al.   Transplantation Reviews

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

(2019) Alicia R. Watson et al.   Frontiers in Immunology

Tolerogenic Dendritic Cells in Organ Transplantation

(2019) Jordi Ochando et al.   TRANSPLANT INTERNATIONAL

Applicability, Safety And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation

(2019) Alberto Sánchez‐Fueyo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunosuppression withdrawal in liver transplant recipients on sirolimus

(2019) Josh Levitsky et al.   HEPATOLOGY

Improved methods for fluorescent labeling and detection of single extracellular vesicles using nanoparticle tracking analysis

(2019) Kristen E. Thane et al.   Scientific Reports

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

(2019) Eros Marin et al.   Cell Metabolism

High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation

(2018) Alan F. Zahorchak et al.   CELLULAR IMMUNOLOGY

Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance

(2018) Yoshihiro Ono et al.   HEPATOLOGY

Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies

(2018) Angus W. Thomson et al.   HUMAN IMMUNOLOGY

Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection

(2018) Muthukumar Gunasekaran et al.   JOURNAL OF IMMUNOLOGY

Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer

(2018) Furong Zeng et al.   Seminars in Immunopathology

TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

(2018) Paloma Riquelme et al.   Nature Communications

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

Interleukin-10-Producing DC-10 Is a Unique Tool to Promote Tolerance Via Antigen-Specific T Regulatory Type 1 Cells

(2018) Michela Comi et al.   Frontiers in Immunology

Characterization of eomesodermin and T-bet expression by allostimulated CD8+ T cells of healthy volunteers and kidney transplant patients in relation to graft outcome

(2018) A. Perez-Gutierrez et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Outcomes of immunosuppression minimization and withdrawal early after liver transplantation

(2018) Abraham Shaked et al.   AMERICAN JOURNAL OF TRANSPLANTATION

ATP and Its Metabolite Adenosine as Regulators of Dendritic Cell Activity

(2018) Cinthia Silva-Vilches et al.   Frontiers in Immunology

Transplant trials with Tregs: perils and promises

(2017) Qizhi Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance

(2017) William Bracamonte-Baran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity

(2017) Matthias P. Domogalla et al.   Frontiers in Immunology

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

(2016) G M Bell et al.   ANNALS OF THE RHEUMATIC DISEASES

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation

(2016) Satoru Todo et al.   HEPATOLOGY

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

(2016) Quan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-10–Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity

(2016) Fanny Kryczanowsky et al.   JOURNAL OF IMMUNOLOGY

Immune regulation in chronic hepatitis C virus infection

(2016) Hans Jakob Hartling et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Tolerogenic dendritic cells

(2016) Maisa C. Takenaka et al.   Seminars in Immunopathology

Tolerogenic dendritic cell therapy in organ transplantation

(2016) Aurélie Moreau et al.   TRANSPLANT INTERNATIONAL

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn’s Disease: A Phase I Study

(2015) Aranzazu Jauregui-Amezaga et al.   Journal of Crohns & Colitis

Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

(2015) Niloufar Safinia et al.   Frontiers in Immunology

T-bet:Eomes Balance, Effector Function, and Proliferation of Cytomegalovirus-Specific CD8+T Cells during Primary Infection Differentiates the Capacity for Durable Immune Control

(2014) Iulia Popescu et al.   JOURNAL OF IMMUNOLOGY

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

(2013) M. B. Ezzelarab et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

(2013) Samantha L. Bailey-Bucktrout et al.   IMMUNITY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Cellular Immune Suppressor Mechanisms in Patients with Hepatocellular Carcinoma

(2012) Fei Zhao et al.   DIGESTIVE DISEASES

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis

(2012) Beatrix Petersen et al.   EMBO JOURNAL

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients

(2012) Josh Levitsky et al.   HEPATOLOGY

Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation

(2012) Camila Macedo et al.   TRANSPLANTATION

Cell Therapy With Autologous Tolerogenic Dendritic Cells Induces Allograft Tolerance Through Interferon-Gamma and Epstein-Barr Virus-Induced Gene 3

(2011) M. Hill et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human regulatory macrophages as a cell-based medicinal product

(2011) James A. Hutchinson et al.   Current Opinion in Organ Transplantation

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

(2011) J. A. Hutchinson et al.   JOURNAL OF IMMUNOLOGY

Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation

(2010) S. J. Divito et al.   BLOOD

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Development of Dendritic Cell-Based Immunotherapy for Autoimmunity

(2010) Catharien M. U. Hilkens et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Situ-Targeting of Dendritic Cells with Donor-Derived Apoptotic Cells Restrains Indirect Allorecognition and Ameliorates Allograft Vasculopathy

(2009) Zhiliang Wang et al.   PLoS One

CD1a expression defines an interleukin-12 producing population of human dendritic cells

(2008) M. Cernadas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunological Monitoring of Renal Transplant Recipients to Predict Acute Allograft Rejection Following the Discontinuation of Tacrolimus

(2008) Ellen Kreijveld et al.   PLoS One