Tolerogenic dendritic cell therapy in organ transplantation

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

(2016) Quan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Eomesoderminlo CTLA4hi Alloreactive CD8+ Memory T Cells Are Associated With Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin–Treated Nonhuman Primates

(2016) Mohamed B. Ezzelarab et al.   TRANSPLANTATION

Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells

(2016) Laura Carretero-Iglesia et al.   TRANSPLANTATION

Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews

(2016) Yanni Zhou et al.   Journal of Immunology Research

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation

(2016) Angus W. Thomson et al.   Frontiers in Immunology

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn’s Disease: A Phase I Study

(2015) Aranzazu Jauregui-Amezaga et al.   Journal of Crohns & Colitis

Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents

(2015) Justine Durand et al.   JOURNAL OF IMMUNOLOGY

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Autologous Dendritic Cells Prolong Allograft Survival ThroughTmem176b-Dependent Antigen Cross-Presentation

(2014) M. Segovia et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tolerogenic dendritic cells and their applications in transplantation

(2014) Haibin Li et al.   Cellular & Molecular Immunology

Transitional-2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival

(2014) Aurélie Moreau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerogenic dendritic cells modified by tacrolimus suppress CD4+ T-cell proliferation and inhibit collagen-induced arthritis in mice

(2014) Yana Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Combining Autologous Dendritic Cell Therapy with CD3 Antibodies Promotes Regulatory T Cells and Permanent Islet Allograft Acceptance

(2014) Marije C. Baas et al.   JOURNAL OF IMMUNOLOGY

Evaluation of the Therapeutic Potential of Bone Marrow-Derived Myeloid Suppressor Cell (MDSC) Adoptive Transfer in Mouse Models of Autoimmunity and Allograft Rejection

(2014) Lucile Drujont et al.   PLoS One

Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer

(2014) Aurélie Moreau et al.   Molecular Therapy-Methods & Clinical Development

Rapamycin Augments Human DC IL-12p70 and IL-27 Secretion to Promote Allogeneic Type1 Polarization Modulated by NK Cells

(2013) C. Macedo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

(2013) M. B. Ezzelarab et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex-vivotolerogenic F4/80+antigen-presenting cells (APC) induce efferent CD8+regulatory T cell-dependent suppression of experimental autoimmune uveitis

(2013) S.-M. Hsu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Prolongation of the Rat Composite Tissue Allograft Survival by the Combination of Tolerogenic Immature Dendritic Cells and Short-Term Treatment With FK506

(2013) S.-C. Eun et al.   TRANSPLANTATION PROCEEDINGS

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

(2013) Dana E Orange et al.   eLife

Regulatory Multitasking of Tolerogenic Dendritic Cells – Lessons Taken from Vitamin D3-Treated Tolerogenic Dendritic Cells

(2013) Tatjana Nikolic et al.   Frontiers in Immunology

Dendritic Cells in Cancer Immunotherapy Clinical Trials: Are We Making Progress?

(2013) Lisa H. Butterfield   Frontiers in Immunology

Regulatory dendritic cells program B cells to differentiate into CD19hiFc IIbhi regulatory B cells through IFN-  and CD40L

(2012) L. Qian et al.   BLOOD

Functional crosstalk between dendritic cells and Foxp3+ regulatory T cells in the maintenance of immune tolerance

(2012) Mara Kornete et al.   Frontiers in Immunology

Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials

(2012) Aurélie Moreau et al.   Frontiers in Immunology

Therapeutic potential of semi-mature dendritic cells for tolerance induction

(2012) Manfred B. Lutz   Frontiers in Immunology

Cell Therapy With Autologous Tolerogenic Dendritic Cells Induces Allograft Tolerance Through Interferon-Gamma and Epstein-Barr Virus-Induced Gene 3

(2011) M. Hill et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Transfer of Regulatory Properties from Tolerogenic to Proinflammatory Dendritic Cells via Induced Autoreactive Regulatory T Cells

(2011) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

(2011) J. A. Hutchinson et al.   JOURNAL OF IMMUNOLOGY

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

(2011) Susanna Celli et al.   NATURE MEDICINE

Tolerogenic dendritic cells and their role in transplantation

(2011) Mohamed Ezzelarab et al.   SEMINARS IN IMMUNOLOGY

Myeloid-Derived Suppressor Cells Protect Islet Transplants by B7-H1 Mediated Enhancement of T Regulatory Cells

(2011) Hong-Shiue Chou et al.   TRANSPLANTATION

Long-Term Allograft Tolerance Is Characterized by the Accumulation of B Cells Exhibiting an Inhibited Profile

(2010) L. Le Texier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation

(2010) S. J. Divito et al.   BLOOD

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Features of the dendritic cell lineage

(2010) Ralph M. Steinman et al.   IMMUNOLOGICAL REVIEWS

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

(2010) Pervinder Sagoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a B cell signature associated with renal transplant tolerance in humans

(2010) Kenneth A. Newell et al.   JOURNAL OF CLINICAL INVESTIGATION

A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals

(2010) Eric J. Gowans et al.   JOURNAL OF HEPATOLOGY

Tolerogenic Dendritic Cells Induce CD4+CD25hiFoxp3+ Regulatory T Cell Differentiation from CD4+CD25-/loFoxp3- Effector T Cells

(2010) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype

(2010) Annaick Pallier et al.   KIDNEY INTERNATIONAL

Malignancy after renal transplantation: the role of immunosuppression

(2010) Inés Rama et al.   Nature Reviews Nephrology

What Have We Learnt from Experimental Renal Transplantation?

(2010) K. Brown et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Pathways of major histocompatibility complex allorecognition

(2009) Behdad Afzali et al.   Current Opinion in Organ Transplantation

Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates

(2009) A. Moreau et al.   FASEB JOURNAL

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients

(2009) C. Luther et al.   JOURNAL OF IMMUNOLOGY

Carbon Monoxide Inhibits TLR-Induced Dendritic Cell Immunogenicity

(2009) S. Remy et al.   JOURNAL OF IMMUNOLOGY

Phase Ib Trial Assessing Autologous, Tumor-pulsed Dendritic Cells as a Vaccine Administered With or Without IL-2 in Patients With Metastatic Melanoma

(2009) Bruce G. Redman et al.   JOURNAL OF IMMUNOTHERAPY

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Prolongation of Composite Tissue Allograft Survival by Immature Recipient Dendritic Cells Pulsed with Donor Antigen and Transient Low-Dose Immunosuppression

(2009) Justin M. Sacks et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Long-Term Survival of Limb Allografts Induced by Pharmacologically Conditioned, Donor Alloantigen-Pulsed Dendritic Cells Without Maintenance Immunosuppression

(2009) Ryosuke Ikeguchi et al.   TRANSPLANTATION

Superiority of Bone Marrow-Derived Dendritic Cells Over Monocyte-Derived Ones for the Expansion of Regulatory T Cells in the Macaque

(2009) Aurélie Moreau et al.   TRANSPLANTATION

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

GMCSF in the absence of other cytokines sustains human dendritic cell precursors with T cell regulatory activity and capacity to differentiate into functional dendritic cells

(2007) Sriram Chitta et al.   IMMUNOLOGY LETTERS

Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion

(2007) Elaine K. Horibe et al.   TRANSPLANT IMMUNOLOGY