Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway

(2019) Ning Shen et al.   MEDICAL SCIENCE MONITOR

microRNA-98 protects sepsis mice from cardiac dysfunction, liver and lung injury by negatively regulating HMGA2 through inhibiting NF-κB signaling pathway

(2019) Jingfa Zhu et al.   CELL CYCLE

Improvement of mesenchymal stromal cells and their derivatives for treating acute liver failure

(2019) Chenxia Hu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms

(2019) Shuang-feng Zi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Differences between congenital-syphilis presenting as sepsis and neonatal sepsis

(2019) Yang Liu et al.   MEDICINE

CD74 knockout protects against LPS‐induced myocardial contractile dysfunction through AMPK‐Skp2‐SUV39H1 ‐mediated demethylation of BCLB

(2019) Yuanfei Luo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic Alcohol Consumption Inhibits Autophagy and Promotes Apoptosis in the Liver

(2018) Mario Menk et al.   International Journal of Medical Sciences

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis

(2018) Zhengyu Jiang et al.   MEDIATORS OF INFLAMMATION

MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway

(2018) Yuhan Chen et al.   Cell Death & Disease

Liver dysfunction in sepsis

(2018) Ewa Woźnica et al.   Advances in Clinical and Experimental Medicine

Kahweol Ameliorates the Liver Inflammation through the Inhibition of NF-κB and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes

(2018) Hye-Young Seo et al.   Nutrients

Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice

(2018) Kaori Endo-Umeda et al.   Scientific Reports

MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

(2018) MinJie Ju et al.   CELL CYCLE

Deletion of caveolin-1 attenuates LPS/GalN-induced acute liver injury in mice

(2018) Tsung-Huang Tsai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathway in vitro and in vivo

(2018) Yan Ding et al.   Frontiers in Pharmacology

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress-dependent contribution of HMGB1 to the interplay between apoptosis and autophagy in diabetic rat liver

(2017) Anja Petrović et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model

(2017) Takehiko Oami et al.   SHOCK

Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo

(2017) Lijing Zhou et al.   Scientific Reports

NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4

(2017) Anand Singh et al.   Scientific Reports

Oxymatrine Induces Liver Injury through JNK Signalling Pathway Mediated by TNF-αIn Vivo

(2016) Hong Lu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Oxidative stress-related biomarkers in multiple sclerosis: a review

(2016) Richard Ibitoye et al.   Biomarkers in Medicine

Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling

(2016) Wenhui Zhong et al.   BIOMEDICINE & PHARMACOTHERAPY

Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia

(2016) Jun Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Liver — guardian, modifier and target of sepsis

(2016) Pavel Strnad et al.   Nature Reviews Gastroenterology & Hepatology

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

Protective effect ofSalvia miltiorrhizaandCarthamus tinctoriusextract against lipopolysaccharide-induced liver injury

(2015) Li-Na Gao   WORLD JOURNAL OF GASTROENTEROLOGY

Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides

(2014) Xuemei Jia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Cross-Disciplinary Perspective on the Innate Immune Responses to Bacterial Lipopolysaccharide

(2014) Yunhao Tan et al.   MOLECULAR CELL

Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress

(2013) Maolong Dong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): A critical discussion

(2013) Deepa K. Ingawale et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

OVEREXPRESSION OF ALDEHYDE DEHYDROGENASE-2 ATTENUATES CHRONIC ALCOHOL EXPOSURE-INDUCED APOPTOSIS, CHANGE IN Akt AND Pim SIGNALLING IN LIVER

(2009) Rui Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia

(2009) Peng Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE