Kahweol Ameliorates the Liver Inflammation through the Inhibition of NF-κB and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes

Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis

(2018) Mattias Carlström et al.   NUTRITION REVIEWS

Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose–Response Meta-Analysis of Prospective Cohort Studies

(2017) Justyna Godos et al.   Nutrients

Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose–Response Meta-Analysis

(2017) Giuseppe Grosso et al.   Nutrients

Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway

(2017) Hye-Young Seo et al.   Oncotarget

Interleukin-1α and Interleukin-1β play a central role in the pathogenesis of fulminant hepatic failure in mice

(2017) Maya Sultan et al.   PLoS One

Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies

(2016) Stefano Marventano et al.   CLINICAL NUTRITION

Coffee consumption and risk of all-cause, cardiovascular, and cancer mortality in smokers and non-smokers: a dose-response meta-analysis

(2016) Giuseppe Grosso et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity

(2016) Kelly A. Rose et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Coffee and cancer risk: A meta-analysis of prospective observational studies

(2016) Anqiang Wang et al.   Scientific Reports

Gut–Liver Axis in Alcoholic Liver Disease

(2015) Gyongyi Szabo   GASTROENTEROLOGY

Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury

(2014) Yuping Jing et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Coffee components and cardiovascular risk: beneficial and detrimental effects

(2014) Justyna Godos et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses

(2014) Chhanda Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic inflammation and progressive liver fibrosis in chronic liver disease

(2014) Albert J Czaja   WORLD JOURNAL OF GASTROENTEROLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Anti-Inflammatory Activities of Inotilone from Phellinus linteus through the Inhibition of MMP-9, NF-κB, and MAPK Activation In Vitro and In Vivo

(2012) Guan-Jhong Huang et al.   PLoS One

Gut-Liver Axis and Sensing Microbes

(2011) Gyongyi Szabo et al.   DIGESTIVE DISEASES

Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation

(2011) M. Larrosa et al.   EUROPEAN JOURNAL OF NUTRITION

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Correction: Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene

(2011) Casimiro Cárdenas et al.   PLoS One

Nuclear Factor-κB/Signal Transducers and Activators of Transcription-1-Mediated Inflammatory Responses in Lipopolysaccharide-Activated Macrophages Are a Major Inhibitory Target of Kahweol, a Coffee Diterpene

(2010) Ting Shen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Role of Nrf2 in Suppressing LPS-Induced Inflammation in Mouse Peritoneal Macrophages by Polyunsaturated Fatty Acids Docosahexaenoic Acid and Eicosapentaenoic Acid

(2010) Hu Wang et al.   MOLECULAR PHARMACEUTICS

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells

(2009) Hyung Gyun Kim et al.   TOXICOLOGY LETTERS

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Protective effect of resveratrol in endotoxemia-induced acute phase response in rats

(2008) Hichem Sebai et al.   ARCHIVES OF TOXICOLOGY

The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress

(2008) Yong Pil Hwang et al.   FEBS LETTERS

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY

The multifaceted mechanisms for coffee’s anti-tumorigenic effect on liver

(2008) Kai-Shan Tao et al.   MEDICAL HYPOTHESES