Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington’s disease via suppressing MAPKs and NF-κB pathways in the striatum

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

(2020) Jia-qi Liu et al.   ACTA PHARMACOLOGICA SINICA

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

(2019) Yuchun Zuo et al.   Journal of Neuroinflammation

CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4

(2019) Chen Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress–induced MAPK and NF-kB pathway in Sprague Dawley rats

(2019) D Jiao et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Ginsenoside Rg1 attenuates protein aggregation and inflammatory response following cerebral ischemia and reperfusion injury

(2019) Tianyang Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginsenoside Rg1 ameliorates palmitic acid-induced insulin resistance in HepG2 cells in association with modulating Akt and JNK activity

(2019) Jiao Mo et al.   Pharmacological Reports

Inflammatory changes in peripheral organs in the BACHD murine model of Huntington's disease

(2019) Priscila Aparecida Costa Valadão et al.   LIFE SCIENCES

Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway

(2019) Man Luo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

(2019) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

(2019) Jian Jing Siew et al.   Nature Communications

Ginsenoside Rg1 Exerts Anti-inflammatory Effects via G Protein-Coupled Estrogen Receptor in Lipopolysaccharide-Induced Microglia Activation

(2019) Xian-Qi Gao et al.   Frontiers in Neuroscience

Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington’s Disease

(2019) Emanuela Paldino et al.   MOLECULAR NEUROBIOLOGY

Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington's disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways

(2019) Eman M. Elbaz et al.   NEUROCHEMISTRY INTERNATIONAL

Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington’s disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway

(2018) Shu-ying Liu et al.   BRAIN RESEARCH

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington’s Disease

(2018) Issa Olakunle Yusuf et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ginsenoside Rg1 protects against hind-limb ischemia reperfusion induced lung injury via NF-κB/COX-2 signaling pathway

(2018) Yuzhu Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington’s disease

(2018) Surekha Ramachandran et al.   METABOLIC BRAIN DISEASE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Sustained Activation of JNK Induced by Quinolinic Acid Alters the BDNF/TrkB Axis in the Rat Striatum

(2018) Ricardo A. Santana-Martínez et al.   NEUROSCIENCE

Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

(2018) Zahra Dargaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal adenosine A2A receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington’s disease

(2018) Maria Rosaria Domenici et al.   Purinergic Signalling

NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model

(2018) Lu Wen et al.   TOXICOLOGY LETTERS

Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions

(2018) Ki Hyun Kim et al.   Journal of Ginseng Research

Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway

(2018) Shi-feng Chu et al.   ACTA PHARMACOLOGICA SINICA

Tolfenamic Acid Attenuates 3-Nitropropionic Acid-Induced Biochemical Alteration in Mice

(2018) Peng Liu et al.   NEUROCHEMICAL RESEARCH

In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington’s disease

(2018) Jeffrey Pido-Lopez et al.   Scientific Reports

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats

(2018) Cuiqin Fan et al.   Frontiers in Immunology

3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged rats

(2017) A. Silva-Palacios et al.   EXPERIMENTAL GERONTOLOGY

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model

(2017) Marja D. Sepers et al.   JOURNAL OF NEUROSCIENCE

Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease

(2017) Irene Sebastianutto et al.   NEUROBIOLOGY OF DISEASE

Inhibiting medial septal cholinergic neurons with DREADD alleviated anxiety-like behaviors in mice

(2017) Yu Zhang et al.   NEUROSCIENCE LETTERS

Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer’s Disease

(2017) Lulin Nie et al.   Oxidative Medicine and Cellular Longevity

Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam

(2017) Francisco Navarrete et al.   PSYCHONEUROENDOCRINOLOGY

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII

(2017) Su Feng et al.   Scientific Reports

Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats

(2016) Shivsharan B. Dhadde et al.   BIOMEDICINE & PHARMACOTHERAPY

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis

(2016) Ralph Andre et al.   CURRENT OPINION IN PHARMACOLOGY

Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways

(2016) Ke Si Wang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways

(2016) Jin-lun Lai et al.   INFLAMMATION

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

(2016) Aaron D. Thome et al.   JOURNAL OF NEUROSCIENCE

Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra

(2016) Xian-Chang Sun​ et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway

(2016) Sumit Jamwal et al.   MOLECULAR NEUROBIOLOGY

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

(2016) Carolin Walter et al.   NEUROPHARMACOLOGY

Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

(2016) Tingting Zhou et al.   NEUROPHARMACOLOGY

Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

(2016) Sumit Jamwal et al.   PHYSIOLOGY & BEHAVIOR

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra

(2016) Yang Heng et al.   TOXICOLOGY LETTERS

Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

(2016) Maria Jimenez-Sanchez et al.   Cold Spring Harbor Perspectives in Medicine

Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q

(2016) Kyoung Joo Cho et al.   Scientific Reports

Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

(2015) Yan Gao et al.   ACTA PHARMACOLOGICA SINICA

Plasma inflammatory biomarkers for Huntington’s disease patients and mouse model

(2015) Kuo-Hsuan Chang et al.   BRAIN BEHAVIOR AND IMMUNITY

Are Striatal Tyrosine Hydroxylase Interneurons Dopaminergic?

(2015) H. S. Xenias et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

(2015) Gopinath Kulasekaran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways

(2015) Minhee Jang et al.   MOLECULAR NEUROBIOLOGY

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease

(2015) Wenda Jiang et al.   PHARMACOLOGY

Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents

(2015) Yu Qian et al.   PLoS One

ADIOL protects against 3-NP-induced neurotoxicity in rats: Possible impact of its anti-oxidant, anti-inflammatory and anti-apoptotic actions

(2015) Diana M.F. Hanna et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage

(2015) Xiao-Jing Zhang et al.   Journal of Functional Foods

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms

(2014) Minhee Jang et al.   BRAIN BEHAVIOR AND IMMUNITY

The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats

(2014) Heba M. Mahdy et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampus Senescence in a Rat Model of D-Galactose-Induced Aging

(2014) Jiahong Zhu et al.   PLoS One

Effects of selective hypothermia on blood-brain barrier integrity and tight junction protein expression levels after intracerebral hemorrhage in rats

(2013) Hongwei Sun et al.   BIOLOGICAL CHEMISTRY

Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats

(2013) Xiu-Yun Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurovascular abnormalities in humans and mice with Huntington's disease

(2013) Chien-Yuan Lin et al.   EXPERIMENTAL NEUROLOGY

The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients

(2013) Robert B. Laprairie et al.   JOURNAL OF NEUROIMMUNOLOGY

Ginsenoside Rg1 attenuates tau phosphorylation in SK-N-SH induced by Aβ‐stimulated THP-1 supernatant and the involvement of p38 pathway activation

(2012) Wei Li et al.   LIFE SCIENCES

Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition

(2012) Francesca R. Fusco et al.   NEUROBIOLOGY OF DISEASE

Ginsenoside Rg1 promotes nonamyloidgenic cleavage of APP via estrogen receptor signaling to MAPK/ERK and PI3K/Akt

(2011) Chun Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model

(2011) Fang Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A novel target for Huntington's disease: ERK at the crossroads of signaling

(2011) László Bodai et al.   BIOESSAYS

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats

(2011) Harikesh Kalonia et al.   LIFE SCIENCES

Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice

(2010) Jin-Feng Hu et al.   BRAIN RESEARCH

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation

(2010) Qian Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Role of matrix metalloproteinase-9 (MMP-9) in striatal blood-brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease

(2010) J. Duran-Vilaregut et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway

(2009) Li Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways

(2009) Ke-Li Ge et al.   JOURNAL OF ETHNOPHARMACOLOGY

NF-kB/NOS cross-talk induced by mitochondrial complex II inhibition: Implications for Huntington's disease

(2007) Maddalena Napolitano et al.   NEUROSCIENCE LETTERS