Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zongyong Zhang, Tengfei Ma, Zhengyi Fu, Yu Feng, Zhen Wang, Song Tian, Zhen Liu, Wei Wei, Xiang Li, Jincao Chen, Wenyuan Zhao
Summary: TBC1Domain Family Member 25 (TBC1D25) plays a crucial role in brain ischemia-reperfusion (I/R) injury, with its deficiency exacerbating neuronal loss, apoptosis, and inflammation. The protective mechanism of TBC1D25 relies on the regulation of the TAK1-JNK/p38 signaling pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Anesthesiology
Yi-Nan Zhang, Ze-Nan Chang, Zi-Meng Liu, Shi-Hong Wen, Ya-Qing Zhan, Han-Jin Lai, Hu-Fei Zhang, Yi Guo, Xu-Yu Zhang
Summary: Intestinal ischemia/reperfusion (I/R) challenge leads to gut barrier dysfunction and distant organ injury. Dexmedetomidine can protect against this damage and minimize gut-vascular barrier (GVB) and liver injuries in mice.
ANESTHESIA AND ANALGESIA
(2022)
Article
Immunology
Jie Pan, Sanyang Chen, Wenzhi Guo, Shengli Cao, Xiaoyi Shi, Jiakai Zhang, Huapeng Zhang, Shuijun Zhang
Summary: Alpinetin pretreatment alleviates inflammatory response and apoptosis induced by hepatic I/R injury, showing significant protective effects in a mouse model. This protective effect may be attributed to the inhibition of NF-kappa B/MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jing-jing Zeng, Han-qing Shi, Fang-fang Ren, Xiao-shan Zhao, Qiao-ying Chen, Dong-juan Wang, Lian-pin Wu, Mao-ping Chu, Teng-fang Lai, Lei Li
Summary: This study investigated the cardioprotective mechanisms of notoginsenoside R1 (NG-R1) in myocardial ischemia/reperfusion (MI/R) injury. The results showed that administration of NG-R1 significantly reduced myocardial infarction area, alleviated myocardial cell damage, and improved cardiac function in MI/R mice. The study also revealed that NG-R1 inhibited apoptosis in cardiomyocytes by suppressing TAK1, JNK, and p38 signaling.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Surgery
Tianzhu Tao, Bo Ye, Yuhai Xu, Yi Wang, Ying Zhu, Ye Tian
Summary: In this study, the protective effects of beta-patchoulene (beta-PAE) on hepatic ischemia-reperfusion (I/R) injury were investigated. The results demonstrated that beta-PAE could alleviate tissue damage and inflammation induced by hepatic I/R injury, and it exerted its effects by modulating the balance between Nrf2/HO-1 and NF-kappa B pathways.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Timothy Borjas, Asha Jacob, HaoTing Yen, Vihas Patel, Gene F. Coppa, Monowar Aziz, Ping Wang
Summary: This study investigates the inhibition of TREM-1 and eCIRP interaction to attenuate liver ischemia/reperfusion injury and inflammation. The results show that inhibiting TREM-1 reduces inflammatory markers and improves survival rate in a mouse model.
Article
Immunology
Zhongbao Chen, Fengjiao Hu, Yalong Zhang, Long Zhang, Tianyu Wang, Chenyang Kong, Haochong Hu, Jiayu Guo, Qi Chen, Bo Yu, Yiting Liu, Jilin Zou, Jiangqiao Zhou, Tao Qiu
Summary: This study revealed that USP29 plays an important role in hepatic ischemia/reperfusion injury by regulating the TAK1-JNK/p38 signaling pathway. Knockout of USP29 exacerbated inflammatory infiltration and injury processes, while overexpression of USP29 alleviated liver injury by decreasing inflammation and inhibiting apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Qianyan Gao, Guodong Li, Yue Zu, Yanjiao Xu, Congyi Wang, Dong Xiang, Wenxi He, Tianze Shang, Xinwei Cheng, Dong Liu, Chengliang Zhang
Summary: Ginseng has the potential to treat liver and gallbladder diseases and alleviate liver injury caused by bile accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biology
Maged E. Mohamed, Nancy S. Younis
Summary: The study found that pretreatment with D-carvone can protect the liver against damage induced by hepatic ischemia-reperfusion. D-carvone downregulates the expression of HMGB1, TLR4, NF kappa B, and NLP3, leading to a reduction in adhesion molecules, neutrophil infiltration, inflammatory mediators, and apoptotic markers.
Article
Pharmacology & Pharmacy
Huiqin Wang, Yantao Yang, Songwei Yang, Siyu Ren, Juling Feng, Yangbo Liu, Haodong Chen, Naihong Chen
Summary: Depression is closely associated with inflammation, and ginsenoside Rg1 can ameliorate neuroinflammation and alleviate depression by suppressing the ubiquitination of Cx43, showing potential therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott, Timothy R. Billiar
Summary: The study demonstrated that MaR1 can protect the liver against hepatic ischemia/reperfusion injury through the ALXR/Akt signaling pathway. MaR1 treatment significantly reduces liver injury, suppresses inflammatory responses, oxidative stress, and decreases hepatocyte apoptosis.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yue Guan, Yan-Li Cao, Jia-Wei Liu, Lan-tao Liu, Yu-Jia Zheng, Xue-Fei Ma, Feng-Guo Zhai
Summary: The study demonstrates that ginsenoside Rg1 effectively suppresses the inflammatory activation of brain microglia cells by inhibiting Toll-like receptor 4 (TLR4) proteins. It shows that ginsenoside Rg1 has the potential to attenuate cerebral ischemia/reperfusion (I/R) injury by targeting TLR4 protein in microglia cells.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Spectroscopy
Fangbo Xia, Jian-Bo Wan
Summary: Lipids play essential roles in biological functions and mass spectrometry is the preferred method for lipid analysis. However, untargeted qualitative profiling and absolute quantitation of lipids are still challenging due to their structural diversity and similarity. Chemical derivatization techniques have been developed to improve lipidomic analysis, providing more structural information and better analytical performance.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Chemistry, Medicinal
Jiang-Kun Dai, Wen-Jia Dan, Jian-Bo Wan
Summary: This review summarizes the research progress on the antifungal activity of beta-carbolines and discusses their mechanisms and structure-activity relationships. Beta-carbolines are considered as promising candidates for the development of new and efficient antifungal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Food Science & Technology
Bingren Tian, Jiayue Liu, Yumei Liu, Jian-Bo Wan
Summary: The popularity of plant bioactive ingredients in the food industry is increasing. However, these ingredients have some deficiencies. Cyclodextrins (CDs) have been extensively studied as excellent carriers for plant bioactive ingredients and can be added to film materials to create bioactive food packaging. This review summarizes the extraction methods of plant bioactive ingredients, the addition of CD inclusion compounds to thin-film materials, and their applications in food packaging. The release model and mechanism of active film materials based on various plant bioactive ingredients with CDs are also highlighted.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Multidisciplinary Sciences
Xiangjun Kong, Huali Zuo, Hsien-Da Huang, Qianru Zhang, Jiayu Chen, Chengwei He, Yuanjia Hu
Summary: This article aims to summarize the current situation, development trends, and emerging technologies in the field of STING modulation. Through the analysis of clinical-stage drugs and global patent status, it is found that research and development on STING are increasing, but the current STING agonists have shown limited anti-tumor efficacy in clinical trials.
JOURNAL OF ADVANCED RESEARCH
(2023)
Editorial Material
Immunology
Senthil Kumaran Satyanarayanan, Huanxing Su, Hi-Joon Park, Kuan-Pin Su
Summary: Psychoneuroimmunology (PNI), a burgeoning concept in recent years, holds potential for effective treatments of mental health disorders. Traditional and alternative therapies have gained momentum due to unmet needs and treatment failures in modern pharmacological approaches, specifically targeting mental disorders. This Special Issue focuses on introducing recent advances in traditional and alternative medications in East Asia at the interface of immunology, neurosciences, molecular psychiatry, and behavioral medicine neurosciences.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Agriculture, Multidisciplinary
Bingren Tian, Jiayue Liu, Wanzhexi Yang, Jian-Bo Wan
Summary: Petroleum-based packaging materials are harmful to the environment and human health due to their nonbiodegradable nature. Researchers are now focusing on developing efficient, biodegradable, and nontoxic food packaging films. Essential oils (EOs) are being used as a natural alternative to synthetic additives due to their favorable antioxidant and antibacterial properties. This review summarizes the mechanisms of EOs and analyzes the properties and performance of food packaging films incorporating EOs. The future prospects and challenges of using EOs-containing biopolymer films in food packaging are also discussed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Clinical Neurology
Po-Han Chou, Cheng-Hao Tu, Chun-Ming Chen, Ming-Kuei Lu, Chon-Haw Tsai, Wan-Ting Hsieh, Hui-Chen Lai, Senthil Kumaran Satyanarayanan, Kuan-Pin Su
Summary: The aim of this study was to investigate the antidepressant efficacy of bilateral theta-burst stimulation (biTBS) in patients with major depressive disorder (MDD) and its effects on brain responses measured by functional magnetic resonance imaging (fMRI) during emotional processing. The results showed that the biTBS group had significantly decreased depression scores at week 8, and this difference persisted during the 24-week follow-up period. At week 4, patients in the biTBS group exhibited increased brain activities over the left superior and middle frontal gyrus during negative emotional stimuli.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Cell Biology
Ke Zhang, Miaodan Huang, Ang Li, Jing Wen, Lingli Yan, Yunhao Li, Liman Guo, Kumaran Satyanarayanan Senthil, Yangyang Zhou, Guobing Chen, Yong Liu, Xiaofei Zhang, Xiaoli Yao, Dajiang Qin, Huanxing Su
Summary: In this study, DIAPH3 is identified as a scaffold protein that initiates liquid-liquid phase separation (LLPS) and forms cytosolic phase-separated DIAPH3 granules (D-granules) in response to stress. These D-granules sequester DIAPH3 and inhibit actin filament assembly in filopodia, serving as a regulatory hub for actin cytoskeletal remodeling during stress.
Article
Immunology
Hsien-Yin Liao, Senthil Kumaran Satyanarayanan, Yi-Wen Lin, Kuan-Pin Su
Summary: This study investigated the specific efficacy and immune effects of acupuncture on pain and depression in patients with comorbid chronic pain and major depressive disorder (MDD). The results showed that specific acupoints for pain did not show greater efficacy than depression-specific acupoints, and pain-specific acupoints even improved depression symptoms better. The study suggests that pain and depression may share common biological mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Neurosciences
Liu Shu-Tsen, Lin Sheng-Che, Chang Jane Pei-Chen, Yang Kai-Jie, Chu Che-Sheng, Yang Chia-Chun, Liang Chih-Sung, Sun Ching-Fang, Wang Shao-Cheng, Senthil Kumaran Satyanarayanan, Su Kuan-Pin
Summary: There is growing evidence that COVID-19 is associated with increased risks of psychiatric sequelae, including depression, anxiety, cognitive impairments, sleep disturbance, and fatigue. This review provides timely updates on clinical research findings and identifies potential key targets for developing effective treatment strategies for long COVID. Additionally, the Formosa Long COVID Multicenter Study (FOCuS) applies the inflammation theory to the pathogenesis and treatment of post-COVID depression and anxiety.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Hsien-Feng Liao, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly in individuals over 40 years old. Mood disorders are frequently comorbid with COPD, but often overlooked or undiagnosed, leading to poor treatment outcomes and increased mortality. The exact link between COPD and mood disorders is still uncertain, but it is believed that inflammation in the lungs, blood, and brain may contribute to the development of mood disorders in COPD. Antidepressants are commonly used to manage mood disorders in COPD, but their efficacy is limited due to tolerability issues. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which regulate inflammatory responses, may offer promising alternatives for managing mood disorders in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jian Zou, Rujie Yang, Ruibing Feng, Jiayue Liu, Jian-Bo Wan
Summary: The potential beneficial effects of ginsenoside Rk2 in mitigating alcoholic liver injury in mice are reported. Rk2 acts as an inhibitor of the NLRP3 inflammasome signaling in the liver, reducing liver inflammation caused by chronic-plus-single-binge ethanol feeding. Additionally, Rk2 improves alcohol-induced intestinal barrier dysfunction by enhancing NLRP6 inflammasome in the intestine.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Nutrition & Dietetics
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Yi-Ting Hsu, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a common lung disease that is associated with pulmonary inflammation and cognitive impairment. The exact mechanisms of cognitive impairment in COPD patients are still unclear, but hypoxia, oxidative stress, systemic inflammation, and cerebral manifestations of these conditions are believed to play crucial roles. Current medications for cognitive impairment in COPD patients may have life-threatening adverse effects, indicating the need for alternative medications. This review discusses the potential role of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in improving cognitive deficits in COPD patients and highlights the importance of clinical studies to evaluate the efficacy of omega-3 PUFAs in managing cognitive impairment in COPD patients.
Editorial Material
Medicine, General & Internal
Senthil Kumaran Satyanarayanan, Zisis Kozlakidis
FRONTIERS IN MEDICINE
(2023)
Review
Emergency Medicine
Zi-Ai Zhao, Lingli Yan, Jing Wen, Senthil Kumaran Satyanarayanan, Feng Yu, Jiahong Lu, Yong U. Liu, Huanxing Su
Summary: Traumatic brain injury (TBI) disrupts normal brain function and can have serious consequences. Blood vessels are often damaged in TBI, leading to impaired cerebral vascular repair, which can result in prolonged symptoms and poor outcomes. Understanding the cellular response and function in vascular repair after TBI is crucial for developing new therapeutic strategies. This review discusses the mechanisms of cerebrovascular impairment following TBI and the role of different cell types in vascular repair, as well as potential treatment techniques targeting these cells.
