Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

(2020) Patrick Lüningschrör et al.   Cell Reports

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

(2020) Purvi C. Trivedi et al.   Cells

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

(2020) Xiaolai Zhou et al.   BRAIN

A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination

(2020) Tuancheng Feng et al.   BRAIN

Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

(2020) Tuancheng Feng et al.   EMBO REPORTS

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

(2020) Xiaolai Zhou et al.   EMBO REPORTS

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

(2020) Hyun-Sik Yang et al.   NEURON

Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology

(2020) Nikhil Milind et al.   PLoS Genetics

A recurrent TMEM106B mutation in hypomyelinating leukodystrophy: A rapid diagnostic assay

(2020) Satoru Ikemoto et al.   BRAIN & DEVELOPMENT

Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non‐motor dysfunction

(2020) Stijn Stroobants et al.   BRAIN PATHOLOGY

Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice

(2020) Georg Werner et al.   EMBO REPORTS

How Lysosomes Sense, Integrate, and Cope with Stress

(2020) Paul Saftig et al.   TRENDS IN BIOCHEMICAL SCIENCES

TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia

(2019) Thomas F. Tropea et al.   ANNALS OF NEUROLOGY

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

(2019) Zeran Li et al.   ACTA NEUROPATHOLOGICA

Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts

(2019) Suvi R. K. Hokkanen et al.   BRAIN PATHOLOGY

Lysosomal size matters

(2019) Mariana E. G. Araujo et al.   TRAFFIC

The lysosomal function of progranulin, a guardian against neurodegeneration

(2018) Daniel H. Paushter et al.   ACTA NEUROPATHOLOGICA

The recurrent mutation in TMEM106B also causes hypomyelinating leukodystrophy in China and is a CpG hotspot

(2018) Huifang Yan et al.   BRAIN

Pathomechanisms of TDP-43 in neurodegeneration

(2018) Ju Gao et al.   JOURNAL OF NEUROCHEMISTRY

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

(2018) Cyril Pottier et al.   LANCET NEUROLOGY

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

(2018) Andrew E. Arrant et al.   Molecular Neurodegeneration

TMEM106B haplotypes have distinct gene expression patterns in aged brain

(2018) Yingxue Ren et al.   Molecular Neurodegeneration

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions

(2018) S. Koga et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

(2018) Samrat T. Kundu et al.   Nature Communications

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

(2018) Alexandra M. Nicholson et al.   Acta Neuropathologica Communications

Variation in TMEM106B in chronic traumatic encephalopathy

(2018) Jonathan D. Cherry et al.   Acta Neuropathologica Communications

The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort

(2017) Sophie R Harding et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Association analysis of polymorphisms in VMAT2 and TMEM106B genes for Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy

(2017) Tao Hu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Progranulin, lysosomal regulation and neurodegenerative disease

(2017) Aimee W. Kao et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice

(2017) Zoe A. Klein et al.   NEURON

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

(2017) Charles C. White et al.   PLOS MEDICINE

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

(2017) Herve Rhinn et al.   Cell Systems

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency

(2017) Xiaolai Zhou et al.   Acta Neuropathologica Communications

The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death

(2016) Hiroaki Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies

(2016) Lin Guo et al.   Cold Spring Harbor Perspectives in Medicine

Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank

(2015) Kevin F. Bieniek et al.   ACTA NEUROPATHOLOGICA

Reassessment of Risk Genotypes (GRN,TMEM106B, andABCC9Variants) Associated With Hippocampal Sclerosis of Aging Pathology

(2015) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

The TMEM106B locus and TDP-43 pathology in older persons without FTLD

(2015) L. Yu et al.   NEUROLOGY

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III

(2015) Mi-Hee Jun et al.   Molecular Brain

TMEM106B: a strong FTLD disease modifier

(2014) Yuetiva Deming et al.   ACTA NEUROPATHOLOGICA

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis

(2014) Julia K. Götzl et al.   ACTA NEUROPATHOLOGICA

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

(2014) Michael D. Gallagher et al.   ACTA NEUROPATHOLOGICA

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia

(2014) Marka van Blitterswijk et al.   ACTA NEUROPATHOLOGICA

TMEM106B Influences Volume of Left-Sided Temporal Lobe and Interhemispheric Structures in the General Population

(2014) Hieab H.H. Adams et al.   BIOLOGICAL PSYCHIATRY

Regulated Intramembrane Proteolysis of the Frontotemporal Lobar Degeneration Risk Factor, TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a)

(2014) Owen A. Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B

(2014) Massimiliano Stagi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and  C9orf72 repeat expansions

(2014) Serena Lattante et al.   NEUROBIOLOGY OF AGING

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

(2013) Benjamin M. Schwenk et al.   EMBO JOURNAL

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

(2013) Rui-Chun Lu et al.   JOURNAL OF NEURAL TRANSMISSION

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

(2013) Alexandra M. Nicholson et al.   JOURNAL OF NEUROCHEMISTRY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

(2012) Owen A. Brady et al.   HUMAN MOLECULAR GENETICS

Membrane Orientation and Subcellular Localization of Transmembrane Protein 106B (TMEM106B), a Major Risk Factor for Frontotemporal Lobar Degeneration

(2012) Christina M. Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

(2012) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

(2012) A. S. Chen-Plotkin et al.   JOURNAL OF NEUROSCIENCE

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease

(2012) N. J. Rutherford et al.   NEUROLOGY

Association of TMEM106B Gene Polymorphism With Age at Onset in Granulin Mutation Carriers and Plasma Granulin Protein Levels

(2011) Carlos Cruchaga et al.   ARCHIVES OF NEUROLOGY

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort

(2011) Julie van der Zee et al.   BRAIN

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

(2011) Mia-Lisa Schmiedt et al.   NEUROBIOLOGY OF DISEASE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

(2011) Todd J. Cohen et al.   TRENDS IN MOLECULAR MEDICINE

Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis

(2010) Ryan Vass et al.   ACTA NEUROPATHOLOGICA

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

(2010) N. Finch et al.   NEUROLOGY

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

The Lysosomal Sialic Acid Transporter Sialin Is Required for Normal CNS Myelination

(2009) L. M. Prolo et al.   JOURNAL OF NEUROSCIENCE

TDP-43 in neurodegenerative disorders

(2008) Casey Cook et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling

(2008) C. Winterstein et al.   JOURNAL OF CELL SCIENCE