Article
Biochemistry & Molecular Biology
Joana Jorge, Nisa Magalhaes, Raquel Alves, Beatriz Lapa, Ana Cristina Goncalves, Ana Bela Sarmento-Ribeiro
Summary: This study evaluated the effect of Brusatol on in vitro models of acute lymphoblastic leukemia (ALL). Brusatol decreased metabolic activity in ALL cell lines, induced cell cycle arrest and cell death, and caused oxidative stress imbalance and mitochondrial disruption.
Article
Cell Biology
Marisol Cano, Sayantan Datta, Lei Wang, Tongyun Liu, Miguel Flores-Bellver, Mira Sachdeva, Debasish Sinha, James T. Handa
Summary: Studies have shown that Nrf2 deficiency affects mitochondrial antioxidant response and exacerbates mitochondrial dysfunction, leading to cell death. Furthermore, Nrf2 indirectly supplies NADPH through influencing PPP and IDH shuttle activity, which also impacts the pathobiology of AMD.
Article
Biochemistry & Molecular Biology
Jonathan Hirschenson, Ryan J. Mailloux
Summary: The study demonstrates that glutathionylation can enhance ROS production by mitochondria, with different effects depending on the oxidizing sources and inhibitors used.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Manuel Aureliano, Ana Luisa De Sousa-Coelho, Connor C. Dolan, Deborah A. Roess, Debbie C. Crans
Summary: Lipid peroxidation (LPO), induced by exposure to vanadium salts and compounds, is a process that affects human health. The LPO reaction involves the oxidation of alkene bonds in polyunsaturated fatty acids, resulting in the formation of radical and reactive oxygen species (ROS). Vanadium species have both direct and indirect effects on ROS formation, making the study of LPO arising from increased ROS challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pamela A. Kakimoto, Julian David C. Serna, Vitor de Miranda Ramos, Antonio Zorzano, Alicia J. Kowaltowski
Summary: Exposure to toxic levels of fatty acids leads to cell damage and death, contributing to the pathogenesis of the metabolic syndrome. Lipotoxicity induces changes in mitochondrial morphology and increases glycolytic flux in cells, while oxidative phosphorylation remains unchanged.
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Environmental Sciences
Xin-Le Lai, Wen-Jie Xiong, Li-Shu Li, Meng-Fan Lan, Jin-Xin Zhang, Yu-Ting Zhou, Dong Niu, Xing Duan
Summary: Zinc, an essential trace mineral, plays a critical role in various cellular processes. Zinc deficiency in patients with polycystic ovary syndrome (PCOS) has been found to affect the reproductive system, particularly oocyte quality. This study established an in vitro model to investigate the regulatory function of zinc in porcine oocyte maturation. The results showed that zinc deficiency disrupted meiotic progress and cytoskeleton structure, impaired mitochondrial function, perturbed cytosolic Ca2+ homeostasis, and induced mitophagy in porcine oocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Physiology
Hasna Tirichen, Hasnaa Yaigoub, Weiwei Xu, Changxin Wu, Rongshan Li, Yafeng Li
Summary: Mitochondrial reactive oxygen species (mtROS) and oxidative stress (OS) result in oxidative damage to cellular components such as lipids, DNA, and proteins, contributing to kidney damage and the progression of chronic kidney disease (CKD).
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Valentina Immediata, Camilla Ronchetti, Daria Spadaro, Federico Cirillo, Paolo Emanuele Levi-Setti
Summary: This review summarizes the role of oxidative stress in conditions associated with female infertility and lists some main antioxidant agents. The importance of DNA repair pathways in improving women's fertility was emphasized by the authors.
Review
Toxicology
Xiaoqing Xu, Xiaohui Wang, Yaqin Yang, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: This article reviews the effects of neonicotinoids on mitochondria and evaluates the protective effects of various active substances against neonicotinoid-induced toxicity. The research found that neonicotinoids can disrupt mitochondrial calcium ions homeostasis, inhibit mitochondrial respiration, and induce reactive oxygen species production, which leads to damage in non-target organisms. However, several active substances can protect against neonicotinoid-induced systemic toxicity by inhibiting oxidative signaling pathways, apoptosis, and lipid peroxidation. The article emphasizes the importance and urgency of developing neonicotinoid antidotes, with a focus on targeted mitochondrial antidotes.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Zhe Wang, Zhaoliang Shen, Sen Lin, Xifan Mei
Summary: The development of artificial hybrid nanozymes using nanomaterials shows great potential in treating ROS-related diseases. These nanozymes have catalytic activities similar to enzymes such as catalase, superoxide dismutase, and glutathione peroxidase, and can target mitochondria. They exhibit cytoprotective effects against ROS-mediated damage and enhance therapeutic effects in various diseases. Moreover, these artificial nanozymes are biocompatible, providing a promising platform for the future development of nanozyme-based therapies.
APPLIED MATERIALS TODAY
(2023)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Medicinal
Xinyu Nie, Xinru Dong, Yuge Hu, Fangjun Xu, Cong Hu, Chang Shu
Summary: Female infertility and pregnancy maintenance are influenced by various factors, including oocyte quantity and quality, genital inflammation, endometriosis, and other diseases. Coenzyme Q10 (CoQ10) has been discovered as a promising adjunct in enhancing male reproductive performance due to its ability to reduce oxidative stress, enhance mitochondrial activity, regulate gene expression, and inhibit inflammatory responses. Additionally, CoQ10 has demonstrated properties that can regulate immune balance, act as an antioxidant, and promote glucose and lipid metabolism, making it a potential therapy for various female reproductive disorders.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
David Mantle, Robert A. Heaton, Iain P. Hargreaves
Summary: Coenzyme Q10 plays crucial roles in the immune system as an electron carrier, antioxidant, and anti-inflammatory agent. It also functions within lysosomes, improving immune system function.
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)