Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction

Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways

(2020) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms and Applications of Redox-Sensitive Green Fluorescent Protein-Based Hydrogen Peroxide Probes

(2018) Leticia Prates Roma et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism

(2018) Mingzhu Bai et al.   ONCOGENE

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

(2018) Ching-Wen Chang et al.   Cell Death & Disease

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

(2018) Jie Wang et al.   Nature Communications

Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

(2018) Kim Ohl et al.   Frontiers in Immunology

Strategies to detect mitochondrial oxidants

(2018) Alicia J. Kowaltowski   Redox Biology

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

(2017) Suvi M Kuosmanen et al.   NUCLEIC ACIDS RESEARCH

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

(2016) Sangbin Lim et al.   CANCER RESEARCH

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria

(2016) Juliana Aparecida Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Transketolase counteracts oxidative stress to drive cancer development

(2016) Iris Ming-Jing Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

(2015) M. R. Terluk et al.   JOURNAL OF NEUROSCIENCE

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

(2014) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells

(2014) Marisol Cano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities

(2013) Juliana A. Ronchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Simple and Scalable Process for the Differentiation of Retinal Pigment Epithelium From Human Pluripotent Stem Cells

(2013) Julien Maruotti et al.   Stem Cells Translational Medicine

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Nrf2-Mediated Resistance to Oxidant-Induced Redox Disruption in Embryos

(2012) Craig Harris et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

In vitro susceptibility of thioredoxins and glutathione to redox modification and aging-related changes in skeletal muscle

(2012) Ivan Dimauro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

(2012) Woojin Jeong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

Structure-based Insights into the Catalytic Power and Conformational Dexterity of Peroxiredoxins

(2010) Andrea Hall et al.   ANTIOXIDANTS & REDOX SIGNALING

What are the sources of hydrogen peroxide production by heart mitochondria?

(2010) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis

(2010) Mireia Niso-Santano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III

(2009) You Hyun Noh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Induction of Sulfiredoxin via an Nrf2-Dependent Pathway and Hyperoxidation of Peroxiredoxin III in the Lungs of Mice Exposed to Hyperoxia

(2008) Soo Han Bae et al.   ANTIOXIDANTS & REDOX SIGNALING