Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells

The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A2s to Adrenic Acid Mobilization in Murine Macrophages

(2020) Patricia Monge et al.   Biomolecules

Generation and Characterization of a Novel Mouse Model that Allows Spatiotemporal Quantification of Pancreatic β-Cell Proliferation

(2020) Shinsuke Tokumoto et al.   DIABETES

Myeloid Liver Kinase B1 depletion is associated with a reduction in alveolar macrophage numbers and an impaired host defense during gram-negative pneumonia

(2020) Natasja A Otto et al.   JOURNAL OF INFECTIOUS DISEASES

MEK5/ERK5 signaling mediates IL‐4‐induced M2 macrophage differentiation through regulation of c‐Myc expression

(2020) João Paulo M. Luiz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lipid mediators and biomarkers associated with type 1 diabetes development

(2020) Alexander J. Nelson et al.   JCI Insight

Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling

(2019) Ann-Christin Otto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two well-differentiated pancreatic neuroendocrine tumor mouse models

(2019) Chung Wong et al.   CELL DEATH AND DIFFERENTIATION

Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice

(2019) Alexander J. Nelson et al.   JOURNAL OF LIPID RESEARCH

β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

(2018) Sabine Tauscher et al.   Cardiovascular Diabetology

Phospholipase A2 catalysis and lipid mediator lipidomics

(2018) Varnavas D. Mouchlis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

iPLA2β and its role in male fertility, neurological disorders, metabolic disorders, and inflammation

(2018) John Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

iPLA2β deficiency attenuates obesity and hepatic steatosis in ob / ob mice through hepatic fatty-acyl phospholipid remodeling

(2016) Xiuling Deng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)

(2016) Jason W. Ashley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

(2014) Chunyan Tan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

(2014) Robert N. Bone et al.   DIABETES

Group VIA Phospholipase A2Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

(2014) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux

(2014) Yolanda F. Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte/Macrophage MMP-14 Modulates Cell Infiltration and T-Cell Attraction in Contact Dermatitis But Not in Murine Wound Healing

(2013) Anke Klose et al.   AMERICAN JOURNAL OF PATHOLOGY

Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling

(2013) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A2s Act on Distinct Phospholipid Pools in Zymosan-Stimulated Mouse Peritoneal Macrophages

(2013) L. Gil-de-Gomez et al.   JOURNAL OF IMMUNOLOGY

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells

(2012) Wenying Quan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

(2012) Jeroen J. T. Otten et al.   FASEB JOURNAL

Survivin Is Required for Beta-Cell Mass Expansion in the Pancreatic Duct-Ligated Mouse Model

(2012) Xiaohong Wu et al.   PLoS One

In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities

(2012) Oscar M. Pello et al.   PLoS One

Recombinase-Mediated Cassette Exchange (RMCE): Traditional Concepts and Current Challenges

(2011) Soeren Turan et al.   JOURNAL OF MOLECULAR BIOLOGY

Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice

(2011) Diana Choi et al.   LABORATORY INVESTIGATION

Beta-Cell Specific Deletion of Dicer1 Leads to Defective Insulin Secretion and Diabetes Mellitus

(2011) Martins Kalis et al.   PLoS One

Mice deficient in Group VIB phospholipase A2 (iPLA2γ) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

(2010) Haowei Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

(2010) Malathi Srinivasan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

(2010) Gao Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Hypothalamus and  -Cell Connection in the Gene-Targeting Era

(2010) M. W. Schwartz et al.   DIABETES

Deletion of Pten in Pancreatic  -Cells Protects Against Deficient  -Cell Mass and Function in Mouse Models of Type 2 Diabetes

(2010) L. Wang et al.   DIABETES

Targeted Inactivation of Kinesin-1 in Pancreatic  -Cells In Vivo Leads to Insulin Secretory Deficiency

(2010) J. Cui et al.   DIABETES

A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β)

(2010) X. Lei et al.   DIABETES OBESITY & METABOLISM

Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development

(2010) Hui Li et al.   FASEB JOURNAL

Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis

(2010) Jochen G. Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

(2009) Jose Antonio Chavez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2Expression

(2009) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted Membrane Homeostasis and Accumulation of Ubiquitinated Proteins in a Mouse Model of Infantile Neuroaxonal Dystrophy Caused by PLA2G6 Mutations

(2008) Ibrahim Malik et al.   AMERICAN JOURNAL OF PATHOLOGY

Skeletal Muscle Group VIA Phospholipase A2(iPLA2β): Expression and Role in Fatty Acid Oxidation†

(2008) Michael J. Carper et al.   BIOCHEMISTRY

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells

(2008) María A. Balboa et al.   FEBS Journal

Smooth Muscle Cell Arachidonic Acid Release, Migration, and Proliferation Are Markedly Attenuated in Mice Null for Calcium-independent Phospholipase A2β

(2008) Sung Ho Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-independent Phospholipase A2(iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

(2008) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iPLA2β: front and center in human monocyte chemotaxis to MCP-1

(2008) Ravi S. Mishra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signal-activated phospholipase regulation of leukocyte chemotaxis: Fig. 1.

(2008) Martha K. Cathcart   JOURNAL OF LIPID RESEARCH

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

(2008) Petra C. Kienesberger et al.   JOURNAL OF LIPID RESEARCH

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice

(2007) Shunzhong Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM