Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections

Genetic determinants of host immunity against human rhinovirus infections

(2020) Ian T. Lamborn et al.   HUMAN GENETICS

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Pathogenicity and transmissibility of 2019-nCoV—A quick overview and comparison with other emerging viruses

(2020) Jieliang Chen   MICROBES AND INFECTION

Another Decade, Another Coronavirus

(2020) Stanley Perlman   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

(2020) Franziska Herster et al.   Nature Communications

Pathogenesis of Chronic Plaque Psoriasis and Its Intersection With Cardio-Metabolic Comorbidities

(2020) Paolo Gisondi et al.   Frontiers in Pharmacology

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

(2020) Víctor Casanova et al.   Frontiers in Immunology

Pregnancy and breastfeeding in the context of Ebola: a systematic review

(2020) Megan E Foeller et al.   LANCET INFECTIOUS DISEASES

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus

(2020) R. Lande et al.   Scientific Reports

Significance of LL-37 on Immunomodulation and Disease Outcome

(2020) Binbin Yang et al.   Biomed Research International

Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2

(2020) Virna Margarita Martín Giménez et al.   JOURNAL OF HUMAN HYPERTENSION

Mesenchymal stem cells: current clinical progress in ARDS and COVID-19

(2020) Kun Xiao et al.   Stem Cell Research & Therapy

Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K3]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1

(2019) Maëva Roy et al.   Viruses-Basel

Achieving cross-reactivity with pan-ebolavirus antibodies

(2019) Liam B King et al.   Current Opinion in Virology

Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37

(2019) Matthieu Ribon et al.   JOURNAL OF AUTOIMMUNITY

Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections

(2019) Aslaa Ahmed et al.   ANTIVIRAL RESEARCH

Current status of small molecule drug development for Ebola virus and other filoviruses

(2019) Megan R Edwards et al.   Current Opinion in Virology

The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis

(2019) Madonna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Antimicrobial Peptides as Therapeutics for Viral Infections

(2019) Aslaa Ahmed et al.   Viruses-Basel

Vitamin D and Phenylbutyrate Supplementation Does Not Modulate Gut Derived Immune Activation in HIV-1

(2019) Catharina Missailidis et al.   Nutrients

Psoriasin (S100A7) is increased in the serum of patients with moderate‐to‐severe psoriasis

(2019) M. Maurelli et al.   BRITISH JOURNAL OF DERMATOLOGY

Human keratinocyte cultures (HaCaT) can be infected by DENV, triggering innate immune responses that include IFNλ and LL37

(2018) Moisés López-González et al.   IMMUNOBIOLOGY

Vertical transmission of herpes simplex virus: an update

(2018) Anil Kumar Bhatta et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs

(2018) Maged Saleh et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neonatal herpes simplex virus infections

(2018) Swetha G. Pinninti et al.   SEMINARS IN PERINATOLOGY

Psoriasis patients demonstrate HLA-Cw*06:02 allele dosage-dependent T cell proliferation when treated with hair follicle-derived keratin 17 protein

(2018) Milyausha Yunusbaeva et al.   Scientific Reports

Dengue infection in India: A systematic review and meta-analysis

(2018) Parasuraman Ganeshkumar et al.   PLoS Neglected Tropical Diseases

Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway

(2018) Miao He et al.   Frontiers in Immunology

The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis

(2018) Cristina Albanesi et al.   Frontiers in Immunology

Anti-LL37 Antibodies Are Present in Psoriatic Arthritis (PsA) Patients: New Biomarkers in PsA

(2018) Loredana Frasca et al.   Frontiers in Immunology

Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells

(2018) Claire L. Greiller et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment

(2018) Laura Mercurio et al.   Cell Death & Disease

Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes

(2017) Judilyn Fuentes-Duculan et al.   EXPERIMENTAL DERMATOLOGY

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

Cathelicidins display conserved direct antiviral activity towards rhinovirus

(2017) Filipa Henderson Sousa et al.   PEPTIDES

In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2

(2017) K. Alagarasu et al.   PEPTIDES

First estimates of the global and regional incidence of neonatal herpes infection

(2017) Katharine J Looker et al.   Lancet Global Health

Zika Virus

(2016) Didier Musso et al.   CLINICAL MICROBIOLOGY REVIEWS

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Antimicrobial peptide LL-37 attenuates infection of hepatitis C virus

(2016) Takuya Matsumura et al.   HEPATOLOGY RESEARCH

Expression of Antimicrobial Peptides in Human Monocytic Cells and Neutrophils in Response to Dengue Virus Type 2

(2016) Jorge I. Castañeda-Sánchez et al.   INTERVIROLOGY

Reduced cytotoxicity and enhanced bioactivity of cationic antimicrobial peptides liposomes in cell cultures and 3D epidermis model against HSV

(2016) Sapir Ron-Doitch et al.   JOURNAL OF CONTROLLED RELEASE

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

(2016) Ka Lun Cheung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C may enhance key amplifiers of psoriasis

(2016) K. Chun et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation

(2016) Francesc Puig-Basagoiti et al.   JOURNAL OF VIROLOGY

Neurological Sequelae Resulting from Encephalitic Alphavirus Infection

(2016) Shannon E. Ronca et al.   Frontiers in Microbiology

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37

(2015) Aline Schögler et al.   EUROPEAN RESPIRATORY JOURNAL

Depot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1–Uninfected Women

(2015) Brandon L. Guthrie et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hormonal Contraception and the Risk of HIV Acquisition: An Individual Participant Data Meta-analysis

(2015) Charles S. Morrison et al.   PLOS MEDICINE

LL-37 Concentrations and the Relationship to Vitamin D, Immune Status, and Inflammation in HIV-Infected Children and Young Adults

(2014) Vin Tangpricha et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA

(2014) Roberto Lande et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN- 

(2014) M. B. Uccellini et al.   JOURNAL OF IMMUNOLOGY

IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes

(2014) M. Peric et al.   JOURNAL OF IMMUNOLOGY

Alarmin Function of Cathelicidin Antimicrobial Peptide LL37 through IL-36γ Induction in Human Epidermal Keratinocytes

(2014) Na Li et al.   JOURNAL OF IMMUNOLOGY

Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy

(2014) J. R. Honda et al.   JOURNAL OF MEDICAL MICROBIOLOGY

No Evidence of Pathogenic Involvement of Cathelicidins in Patient Cohorts and Mouse Models of Lupus and Arthritis

(2014) D. Kienhöfer et al.   PLoS One

Cathelicidin Antimicrobial Peptide LL-37 in Cholesteatoma Enables Keratinocyte Reactivity with Cytosolic DNA

(2014) Z. Chi et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

Molecular Evolution of Zika Virus during Its Emergence in the 20th Century

(2014) Oumar Faye et al.   PLoS Neglected Tropical Diseases

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

(2014) Elmar Pieterse et al.   Frontiers in Immunology

Cathelicidin LL-37 and HSV-1 Corneal Infection: Peptide Versus Gene Therapy

(2014) Chyan-Jang Lee et al.   Translational Vision Science & Technology

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

(2013) Emily Gwyer Findlay et al.   BIODRUGS

Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells

(2013) Youichi Ogawa et al.   Cell Host & Microbe

The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+Handling and Induces Ca2+-Independent Apoptosis

(2013) Johanna Säll et al.   Journal of Innate Immunity

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats

(2012) Markus H Hoffmann et al.   ANNALS OF THE RHEUMATIC DISEASES

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

Antimicrobial peptides in the pathogenesis of psoriasis

(2012) Shin MORIZANE et al.   JOURNAL OF DERMATOLOGY

HIV-Neutralizing Activity of Cationic Polypeptides in Cervicovaginal Secretions of Women in HIV-Serodiscordant Relationships

(2012) Pauline Levinson et al.   PLoS One

Bone Loss in Rheumatoid Arthritis: Systemic, Periarticular, and Focal

(2012) Chad Deal   Current Rheumatology Reports

Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus

(2011) Alexander Kreuter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Effects of cathelicidin and its fragments on three key enzymes of HIV-1

(2011) Jack Ho Wong et al.   PEPTIDES

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37

(2010) Anna Krasnodembskaya et al.   STEM CELLS

Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition

(2009) Pauline Levinson et al.   AIDS

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Membrane Proteinase 3 Expression on Neutrophils Was Downregulated After Treatment With Infliximab in Patients With Rheumatoid Arthritis

(2008) Takeshi Matsumoto et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

The Human Antimicrobial Peptide LL-37 Suppresses Apoptosis in Keratinocytes

(2008) Clara I. Chamorro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY