Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA

(2018) Alicia Wong et al.   JOURNAL OF IMMUNOLOGY

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

(2017) Marie Toussaint et al.   NATURE MEDICINE

Cathelicidins display conserved direct antiviral activity towards rhinovirus

(2017) Filipa Henderson Sousa et al.   PEPTIDES

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock

(2017) Baihong Pan et al.   Scientific Reports

Antimicrobial Peptides and Innate Lung Defenses

(2016) Pieter S. Hiemstra et al.   CHEST

iPAD or PADi—‘tablets’ with therapeutic disease potential?

(2016) Huw D Lewis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Carbamylated LL-37 as a modulator of the immune response

(2016) Catalin Koro et al.   Innate Immunity

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

(2016) Maximilian F. Konig et al.   Frontiers in Immunology

2-Chloroacetamidine, a novel immunomodulator, suppresses antigen-induced mouse airway inflammation

(2015) Y. Maezawa et al.   ALLERGY

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37

(2015) Aline Schögler et al.   EUROPEAN RESPIRATORY JOURNAL

Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes

(2015) Yebin Zhou et al.   MEDIATORS OF INFLAMMATION

Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses

(2015) Shweta Tripathi et al.   PLoS One

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

(2015) Elena B Lugli et al.   ARTHRITIS RESEARCH & THERAPY

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

(2014) Guangshun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay

(2014) Dres Damgaard et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis

(2014) J. Koziel et al.   JOURNAL OF IMMUNOLOGY

Association of interleukin-8 and neutrophils with nasal symptom severity during acute respiratory infection

(2014) Kelsey M. Henriquez et al.   JOURNAL OF MEDICAL VIROLOGY

Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

(2014) Sigrun Eick et al.   Orphanet Journal of Rare Diseases

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

Antiviral potential of cathelicidins

(2013) Peter G Barlow et al.   Future Microbiology

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

The three human monocyte subsets: implications for health and disease

(2012) Kok Loon Wong et al.   IMMUNOLOGIC RESEARCH

Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticlesin vitroandin vivo

(2012) Bashir M Mohamed et al.   Nanomedicine

Peptidylarginine Deiminases Present in the Airways during Tobacco Smoking and Inflammation Can Citrullinate the Host Defense Peptide LL-37, Resulting in Altered Activities

(2011) Ola Kilsgård et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

(2011) Erika Darrah et al.   ANNALS OF THE RHEUMATIC DISEASES

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases

(2010) Marie-Claire Méchin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Human Host Defense Peptide LL-37 Interacts with Neisseria meningitidis Capsular Polysaccharides and Inhibits Inflammatory Mediators Release

(2010) Susu M. Zughaier et al.   PLoS One

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES