Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

(2016) Rachael Jarrett et al.   Science Translational Medicine

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals

(2015) Sumithra Subramaniam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bee venom processes human skin lipids for presentation by CD1a

(2015) Elvire A. Bourgeois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melanocyte antigen triggers autoimmunity in human psoriasis

(2015) Akiko Arakawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and safety of brodalumab in subpopulations of patients with difficult-to-treat moderate-to-severe plaque psoriasis

(2015) Kim Papp et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

(2015) Richard W Birkinshaw et al.   NATURE IMMUNOLOGY

Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

(2015) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guttate psoriasis is associated with an intermediate phenotype of impaired Langerhans cell migration

(2014) L.H. Eaton et al.   BRITISH JOURNAL OF DERMATOLOGY

The plot thickens while the scope broadens: a holistic view on IL-17 in psoriasis and other inflammatory disorders

(2014) Michael P. Schön   EXPERIMENTAL DERMATOLOGY

Cellular sources of IL-17 in psoriasis: a paradigm shift?

(2014) Romy R. M. C. Keijsers et al.   EXPERIMENTAL DERMATOLOGY

Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR + ILC3 in Lesional Skin and Blood of Psoriasis Patients

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

(2014) M. Quaranta et al.   Science Translational Medicine

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

Increased number and frequency of group 3 innate lymphoid cells in nonlesional psoriatic skin

(2013) B. Dyring-Andersen et al.   BRITISH JOURNAL OF DERMATOLOGY

Ustekinumab for the treatment of nail psoriasis in heavily treated psoriatic patients

(2013) Magalys Vitiello et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

T cell–derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases

(2013) Irit Shefler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment-Related Restoration of Langerhans Cell Migration in Psoriasis

(2013) Frances L. Shaw et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis

(2013) Federica Villanova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

(2013) Annemieke de Jong et al.   NATURE IMMUNOLOGY

IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation

(2012) Anna Balato et al.   EXPERIMENTAL DERMATOLOGY

Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study

(2012) A.B. Kimball et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β

(2010) Konstantin Yakimchuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

(2010) Annemieke de Jong et al.   NATURE IMMUNOLOGY

Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis

(2010) Pieter C. M. Res et al.   PLoS One

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin

(2009) Lakshmi Krishnamoorthy et al.   Nature Chemical Biology

Presentation of lipid antigens to T cells

(2008) Lucia Mori et al.   IMMUNOLOGY LETTERS

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

(2008) Kim A Papp et al.   LANCET

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC