Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview

Anti-inflammatory Diet In Rheumatoid Arthritis (ADIRA)—a randomized, controlled crossover trial indicating effects on disease activity

(2020) Anna K E Vadell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology : Reproducibility of natural product research

(2020) Angelo A. Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

(2020) Mihai G. Netea et al.   CELL

Interaction between microbiota and immunity in health and disease

(2020) Danping Zheng et al.   CELL RESEARCH

Drivers and regulators of humoral innate immune responses to infection and cancer

(2020) Deepak Kumar et al.   MOLECULAR IMMUNOLOGY

A Review of the Pharmacological Action of Astragalus Polysaccharide

(2020) Yijun Zheng et al.   Frontiers in Pharmacology

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

(2020) Xiao Meng et al.   Foods

Epiphanies of well-known and newly discovered macromolecular carbohydrates – A review

(2020) Priscilla Barbosa Sales Albuquerque et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Seed of Industrial Hemp (Cannabis sativa L.): Nutritional Quality and Potential Functionality for Human Health and Nutrition

(2020) Barbara Farinon et al.   Nutrients

Influence of different supplementation on platelet aggregation in patients with rheumatoid arthritis

(2019) Marijana Tomic-Smiljanic et al.   CLINICAL RHEUMATOLOGY

Short‐chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells

(2019) Maik Luu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of bovine milk fat and vegetable fat for infant formula: Implications for infant health

(2019) Jeske H.J. Hageman et al.   INTERNATIONAL DAIRY JOURNAL

Labdane and Abietane Diterpenoids from Juniperus oblonga and Their Cytotoxic Activity

(2019) Qiao et al.   MOLECULES

Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

(2019) Chang Liu et al.   MOLECULES

Glucan and Mannan—Two Peas in a Pod

(2019) Tatiana A. Korolenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Artocarpus tonkinensis Protects Mice Against Collagen-Induced Arthritis and Decreases Th17 Cell Function

(2019) Sabrina Adorisio et al.   Frontiers in Pharmacology

Editorial: Immunology of Aging

(2019) Graham Pawelec et al.   Frontiers in Immunology

Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression

(2019) Dan Chen et al.   Journal of Functional Foods

Mechanisms of Action of trans Fatty Acids

(2019) Antwi-Boasiako Oteng et al.   Advances in Nutrition

Microbiota‐dependent and ‐independent effects of dietary fibre on human health

(2019) Yang Cai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Best practice in research – Overcoming common challenges in phytopharmacological research

(2019) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

(2019) Naren Gajenthra Kumar et al.   Nutrients

The Influence of Dietary Fatty Acids on Immune Responses

(2019) Urszula Radzikowska et al.   Nutrients

Flaxseed: its bioactive components and their cardiovascular benefits

(2018) Mihir Parikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The role of adjuvant immunomodulatory agents for treatment of severe influenza

(2018) David S. Hui et al.   ANTIVIRAL RESEARCH

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

(2018) Muhammad Torequl Islam et al.   CANCER LETTERS

Metabolite profiling of green, green/red, and red lettuce cultivars: Variation in health beneficial compounds and antioxidant potential

(2018) Dae-Eun Kim et al.   FOOD RESEARCH INTERNATIONAL

Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of Citrus unshiu

(2018) Myoung-Sook Shin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fatty acid profiles and sn -2 fatty acid distribution of γ-linolenic acid-rich Borago species

(2018) José Luis Guil-Guerrero et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance — A review

(2018) Ramesh Kumar Saini et al.   LIFE SCIENCES

Omega-6 fatty acids and inflammation

(2018) Jacqueline K. Innes et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Mixing ratio optimization for functional complex extracts of Rhodiola crenulata , Panax quinquefolius , and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models

(2018) Hee-Do Hong et al.   Journal of Functional Foods

Metabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats

(2018) Yifan Sun et al.   Food & Function

Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2–1 and Prevents Doxorubicin-Induced Ileitis

(2018) Neha M. Sahasrabudhe et al.   Frontiers in Immunology

Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

(2018) Yan Dai et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Mannans: An overview of properties and application in food products

(2018) Saumya Singh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phytochemistry and pharmacology of the genus Leonurus : The herb to benefit the mothers and more

(2018) Rui-Han Zhang et al.   PHYTOCHEMISTRY

Linseed essential oil - Source of Lipids as Active Ingredients for Pharmaceuticals and Nutraceuticals

(2018) Joana Campos et al.   CURRENT MEDICINAL CHEMISTRY

Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea

(2018) Michele Catanzaro et al.   MOLECULES

Ginseng: A dietary supplement as immune-modulator in various diseases

(2018) Muhammad Riaz et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Immune Function and Micronutrient Requirements Change over the Life Course

(2018) Silvia Maggini et al.   Nutrients

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

(2018) Wuwen Feng et al.   Frontiers in Pharmacology

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action

(2017) Shimaa Ibrahim Abdelmonym Mohamed et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Impact of Omega-3 Fatty Acids on the Gut Microbiota

(2017) Lara Costantini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tinospora species: An overview of their modulating effects on the immune system

(2017) Md. Areeful Haque et al.   JOURNAL OF ETHNOPHARMACOLOGY

Network ethnopharmacological evaluation of the immunomodulatory activity of Withania somnifera

(2017) Uma Chandran et al.   JOURNAL OF ETHNOPHARMACOLOGY

Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

(2017) Ninh Khac Ban et al.   Journal of Natural Medicines

A new 12,17-cyclo-labdane diterpenoid from the twigs of Dacrycarpus imbricatus

(2017) Zuofa Yang et al.   NATURAL PRODUCT RESEARCH

Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both?

(2017) Alessio Molfino et al.   Oxidative Medicine and Cellular Longevity

Labdane diterpenoids as potential anti-inflammatory agents

(2017) Quy T.N. Tran et al.   PHARMACOLOGICAL RESEARCH

Withania somnifera (Linn.) Dunal: a review of chemical and pharmacological diversity

(2017) Rishu Kalra et al.   PHYTOCHEMISTRY REVIEWS

Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis

(2017) Xiao-Yang Hu et al.   PLoS One

Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells

(2017) Hao Wu et al.   Scientific Reports

Aristolochic Acid in the Etiology of Renal Cell Carcinoma

(2016) M. L. Hoang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Physicochemical properties and structural characterization of a galactomannan from Sophora alopecuroides L. seeds

(2016) Rui Guo et al.   CARBOHYDRATE POLYMERS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer

(2016) Venkat N. Vangaveti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Immunomodulators in SLE: Clinical evidence and immunologic actions

(2016) L. Durcan et al.   JOURNAL OF AUTOIMMUNITY

Flavonoid-enriched fraction fromEchinodorus macrophyllusaqueous extract exhibits high in-vitro and in-vivo anti-inflammatory activity

(2016) Girlaine Pereira da Silva et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging

(2016) Francisca Echeverría et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Evaluation of the toxicokinetics and apoptotic potential of ethanol extract from Echinodorus macrophyllus leaves in vivo

(2016) Márcia Soares Mattos Vaz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor

(2016) Alicja Kuban-Jankowska et al.   Oncotarget

Structure–function relationships of immunostimulatory polysaccharides: A review

(2015) Sónia S. Ferreira et al.   CARBOHYDRATE POLYMERS

Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response

(2015) Minh Thu Nguyen et al.   INFECTION AND IMMUNITY

Modulation of Peroxisome Proliferator-Activated Receptor gamma (PPAR γ) by Conjugated Fatty Acid in Obesity and Inflammatory Bowel Disease

(2015) Gaofeng Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver

(2015) Swapnil V. Shewale et al.   JOURNAL OF LIPID RESEARCH

Evaluation of oil content and fatty acid composition in the seed of grapevine varieties

(2015) Jaromír Lachman et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Antioxidant, Anti-inflammatory, and Chemoprotective Properties ofAcacia catechuHeartwood Extracts

(2015) Sidney J. Stohs et al.   PHYTOTHERAPY RESEARCH

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents

(2015) Ao Guo et al.   Scientific Reports

Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

(2015) Ibrahim Jantan et al.   Frontiers in Plant Science

Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis

(2014) Dagmar Simon et al.   ADVANCES IN THERAPY

Resveratrol plus carboxymethyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis

(2014) Michele Miraglia Del Giudice et al.   CURRENT MEDICAL RESEARCH AND OPINION

Effects of dietary Astragalus polysaccharides (APS) on growth performance, immunological parameters, digestive enzymes, and intestinal morphology of Nile tilapia (Oreochromis niloticus)

(2014) Eman Zahran et al.   FISH & SHELLFISH IMMUNOLOGY

Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response

(2014) Abdelaziz S.A. Abuelsaad   MICROBIAL PATHOGENESIS

CODEX-aligned dietary fiber definitions help to bridge the ‘fiber gap’

(2014) Julie Miller Jones   Nutrition Journal

The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review

(2014) Majid Asadi-Samani et al.   Asian Pacific Journal of Tropical Medicine

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

(2013) Ae Li Lee et al.   ANNALS OF NUTRITION AND METABOLISM

Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use

(2013) Susanna M Proudman et al.   ANNALS OF THE RHEUMATIC DISEASES

Polypotency of the immunomodulatory effect of pectins

(2013) S. V. Popov et al.   BIOCHEMISTRY-MOSCOW

Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents

(2013) Monica Viladomiu et al.   Evidence-based Complementary and Alternative Medicine

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations

(2013) Rikke M. Kjærup et al.   IMMUNOBIOLOGY

Up to 15-year clinical follow-up of a pilot Phase III immunotherapy study in stage II breast cancer patients using oxidized mannan–MUC1

(2013) Stamatis Vassilaros et al.   Immunotherapy

Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis

(2013) Saurabh Bhatia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity

(2013) Elena Fattore et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Fructooligosaccharides and fructans analysis in plants and food crops

(2013) Noureddine Benkeblia   JOURNAL OF CHROMATOGRAPHY A

Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: a review of the evidence

(2013) Silvia Lorente-Cebrián et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing

(2013) Fadi Saade et al.   VACCINE

Studies on wheat bran Arabinoxylan for its immunostimulatory and protective effects against avian coccidiosis

(2012) Masood Akhtar et al.   CARBOHYDRATE POLYMERS

Mass spectrometry characterization of an Aloe vera mannan presenting immunostimulatory activity

(2012) Joana Simões et al.   CARBOHYDRATE POLYMERS

Structure elucidation and immunological activity of a novel pectic polysaccharide from the stems of Avicennia marina

(2012) Xubo Fang et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Structural characterization and immunostimulatory activity of a novel linear α-(1 → 6)-D-glucan isolated from Panax ginseng C. A. Meyer

(2012) Lin Sun et al.   GLYCOCONJUGATE JOURNAL

Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice

(2012) Xiaogang Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Changing scenario for promotion and development of Ayurveda – way forward

(2012) Pulok K. Mukherjee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragalus membranaceus Extract Activates Immune Response in Macrophages via Heparanase

(2012) Qiaojing Qin et al.   MOLECULES

Update on the Role of Systemic Vitamin D in Atopic Dermatitis

(2012) Krishna Mutgi et al.   PEDIATRIC DERMATOLOGY

Sustainable food-packaging materials based on future biorefinery products: Xylans and mannans

(2012) Kirsi S. Mikkonen et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses

(2012) Yoshikazu Honda-Okubo et al.   VACCINE

Nasal Acai Polysaccharides Potentiate Innate Immunity to Protect against Pulmonary Francisella tularensis and Burkholderia pseudomallei Infections

(2012) Jerod A. Skyberg et al.   PLoS Pathogens

Characterization and immunostimulating activity of a water-soluble polysaccharide isolated from Haematococcus lacustris

(2011) Jae Kweon Park et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Separation, structure characterization, conformation and immunomodulating effect of a hyperbranched heteroglycan from Radix Astragali

(2011) Jun-Yi Yin et al.   CARBOHYDRATE POLYMERS

Effects of Astragalus polysaccharide liposome on lymphocyte proliferation in vitro and adjuvanticity in vivo

(2011) Yunpeng Fan et al.   CARBOHYDRATE POLYMERS

Pharmacological review on Centella asiatica: A potential herbal cure-all

(2011) KashmiraJ Gohil et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine

(2011) Jiefeng Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Immunomodulatory Activity of Dietary Fiber: Arabinoxylan and Mixed-Linked Beta-Glucan Isolated from Barley Show Modest Activities in Vitro

(2011) Anne Berit Samuelsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural glycans and glycoconjugates as immunomodulating agents

(2011) Ilona Chlubnová et al.   NATURAL PRODUCT REPORTS

Polysaccharides Isolated from Açaí Fruit Induce Innate Immune Responses

(2011) Jeff Holderness et al.   PLoS One

Dietary fish oil and flaxseed oil suppress inflammation and immunity in cats

(2011) Hyun Joo Park et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response

(2010) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Structural characterization of immunostimulating polysaccharide from cultured mycelia of Cordyceps militaris

(2010) Jong Seok Lee et al.   CARBOHYDRATE POLYMERS

Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction

(2010) Sumei Zhou et al.   CARBOHYDRATE POLYMERS

Carrageenan from Solieria chordalis (Gigartinales): Structural analysis and immunological activities of the low molecular weight fractions

(2010) Bondu Stephanie et al.   CARBOHYDRATE POLYMERS

Studies on chemistry and immuno- modulating mechanism of a glycoconjugate from Lycium barbarum L.

(2010) Xue-Mei Peng et al.   CHINESE JOURNAL OF CHEMISTRY

A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents

(2010) Sailendra Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

(2010) Li Cao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Two rings in them all: The labdane-related diterpenoids

(2010) Reuben J. Peters   NATURAL PRODUCT REPORTS

Borage oil in the treatment of atopic dermatitis

(2010) Rachel H. Foster et al.   NUTRITION

Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract

(2010) Puthanapura M. Chandrashekar et al.   PHYTOCHEMISTRY

Key concepts in immunology

(2010) Muriel Moser et al.   VACCINE

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement

(2010) David Moher et al.   International Journal of Surgery

Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer

(2009) Rui Li et al.   CARBOHYDRATE POLYMERS

Immunostimulatory properties of coffee mannans

(2009) Joana Simões et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Th1/Th2 cytokine production by clove-treated mice

(2009) Tatiana Fernanda Bachiega et al.   NATURAL PRODUCT RESEARCH

Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats

(2009) Tarek Boussetta et al.   PLoS One

MINERVAL INDUCES APOPTOSIS IN JURKAT AND OTHER CANCER CELLS

(2008) Victoria Llado et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

β-Glucans, History, and the Present: Immunomodulatory Aspects and Mechanisms of Action

(2008) M. Novak et al.   Journal of Immunotoxicology

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

Mannans as stabilizers of oil-in-water beverage emulsions

(2008) Kirsi S. Mikkonen et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita

(2008) Gang Xie et al.   PHYTOCHEMISTRY

Spruce-derived mannans – A potential raw material for hydrocolloids and novel advanced natural materials

(2007) Stefan Willför et al.   CARBOHYDRATE POLYMERS

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

(2007) Badreldin H. Ali et al.   FOOD AND CHEMICAL TOXICOLOGY