Endothelial-to-Mesenchymal Transition in Cancer

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial

(2020) Antoine Italiano et al.   LANCET ONCOLOGY

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition

(2020) Simone F. Glaser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

(2020) Menggui Huang et al.   Science Translational Medicine

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

(2020) Katerina Rohlenova et al.   Cell Metabolism

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models

(2019) Se-Hyuk Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases

(2019) Sonsoles Piera-Velazquez et al.   PHYSIOLOGICAL REVIEWS

Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

(2019) Takeo Tsutsumi et al.   PLoS One

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

(2019) Silvia C. Formenti et al.   Journal for ImmunoTherapy of Cancer

Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells

(2019) Nami O. Yamada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Dose Radiation Increases Notch1 in Tumor Vasculature

(2019) Debarshi Banerjee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor Endothelial Heterogeneity in Cancer Progression

(2019) Nako Maishi et al.   Cancers

Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma

(2019) Chi-Shuan Fan et al.   Journal of Hematology & Oncology

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β–Smad Signaling

(2018) Tadanori Mammoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RhoJ promotes hypoxia induced endothelial-to-mesenchymal transition by activating WDR5 expression

(2018) Li Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

(2018) Jianhua Xiong et al.   MOLECULAR CELL

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

(2018) Yan Li et al.   Nature Reviews Cardiology

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching

(2018) Shamini Murugavel et al.   Frontiers in Pharmacology

Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

(2018) Jin Gu Cho et al.   Frontiers in Immunology

Epigenetic Regulation of Endothelial-to-Mesenchymal Transition in Chronic Heart Disease

(2018) Melanie S. Hulshoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

(2018) Tianrun Liu et al.   Nature Communications

Invasive Colon Cancer Cells Induce Transdifferentiation of Endothelium to Cancer-Associated Fibroblasts through Microtubules Enriched in Tubulin-β3

(2018) Marta Wawro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization

(2018) Seo-Hyun Choi et al.   Nature Communications

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition

(2018) Nao Nagai et al.   PLoS Genetics

NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma

(2018) Nagore I. Marín-Ramos et al.   CANCER LETTERS

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

Osteopontin–integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer

(2017) Chi-Shuan Fan et al.   Oncotarget

When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition

(2016) Ákos Gasparics et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

(2016) Menggui Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fine-tuning vascular fate during endothelial-mesenchymal transition

(2016) Lin Xiao et al.   JOURNAL OF PATHOLOGY

Differential effect of hypoxia on early endothelial–mesenchymal transition response to transforming growth beta isoforms 1 and 2

(2016) Meghan Doerr et al.   MICROVASCULAR RESEARCH

Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells

(2016) S-H Wang et al.   ONCOGENE

Slug Is Associated With Tumor Metastasis and Angiogenesis in Ovarian Cancer

(2016) Anxin Gu et al.   Reproductive Sciences

Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis

(2015) Elodie Mintet et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Endothelial Cells with Distinct Patterns of TGF -Driven Endothelial-to-Mesenchymal Transition

(2015) L. Xiao et al.   CANCER RESEARCH

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

(2015) Xiao Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2

(2015) Monika Maleszewska et al.   CELLULAR SIGNALLING

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

(2015) Pegah Ghiabi et al.   Journal of Translational Medicine

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation

(2015) István A. Krizbai et al.   PLoS One

Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT

(2015) Guadalupe Tirma González-Mateo et al.   Biomed Research International

Endothelial-mesenchymal transition in normal human esophageal endothelial cells cocultured with esophageal adenocarcinoma cells: role of IL-1β and TGF-β2

(2014) Linghui Nie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study

(2014) Richard J. Kovacs et al.   Cardiovascular Toxicology

TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

(2014) D. R. Principe et al.   JNCI-Journal of the National Cancer Institute

MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells

(2014) Kai Zhu et al.   Scientific Reports

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development

(2012) Victoria C. Garside et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

(2011) M. Franco et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A

(2011) Hajime Mihira et al.   JOURNAL OF BIOCHEMISTRY

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

(2010) Iris Helfrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Snail is required for TGF -induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

(2008) T. Kokudo et al.   JOURNAL OF CELL SCIENCE