Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Long Non-Coding RNA GAPLINC Promotes Tumor-Like Biologic Behaviors of Fibroblast-Like Synoviocytes as MicroRNA Sponging in Rheumatoid Arthritis Patients

(2018) Bi Yao Mo et al.   Frontiers in Immunology

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats

(2017) Quan Hu et al.   Frontiers in Cellular Neuroscience

Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs

(2017) Elaine Y. C. Hsia et al.   Nature Communications

Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling

(2017) Wei-xiang Peng et al.   Frontiers in Immunology

Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway

(2016) Zhai Ertao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis

(2015) Shang-ling Zhu et al.   Cellular & Molecular Immunology

Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides

(2015) Jheelam Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

ActivatingPIK3CAMutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

(2015) Christian D. Young et al.   MOLECULAR & CELLULAR PROTEOMICS

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

(2014) Jillian Brechbiel et al.   CANCER TREATMENT REVIEWS

Cyclopamine: From Cyclops Lambs to Cancer Treatment

(2014) Stephen T. Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target

(2014) Mingxia Wang et al.   Journal of Immunology Research

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway

(2012) Jing-tao Lu et al.   ACTA PHARMACOLOGICA SINICA

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

(2010) Hong Chang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

(2010) M. Mimeault et al.   PHARMACOLOGICAL REVIEWS

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

(2010) Katie L. Ayers et al.   TRENDS IN CELL BIOLOGY

Glucocorticoids increase α5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion

(2009) Torsten Lowin et al.   ARTHRITIS AND RHEUMATISM

MAPK phosphatases as novel targets for rheumatoid arthritis

(2008) Jennifer A Ralph et al.   EXPERT OPINION ON THERAPEUTIC TARGETS