Scaffold-Mediated Gene Delivery for Osteochondral Repair

Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!

(2020) Nina Bono et al.   Pharmaceutics

Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues

(2020) Nuseibah AL Qtaish et al.   Pharmaceutics

Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer

(2020) Jagadeesh K. Venkatesan et al.   Pharmaceutics

mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering

(2020) Adriana M. Ledo et al.   BIOMATERIALS

Small-Diameter Subchondral Drilling Improves DNA and Proteoglycan Content of the Cartilaginous Repair Tissue in a Large Animal Model of a Full-Thickness Chondral Defect

(2020) Patrick Orth et al.   Journal of Clinical Medicine

Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview

(2020) Natalia Carballo-Pedrares et al.   Pharmaceutics

3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects

(2020) Susan Critchley et al.   Acta Biomaterialia

Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model

(2019) Ryosuke Hishimura et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues

(2019) T. Gonzalez-Fernandez et al.   JOURNAL OF CONTROLLED RELEASE

Scaffold‐Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair

(2019) Domhnall C Kelly et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications

(2019) Raj Rai et al.   Polymers

Cationic micelle: A promising nanocarrier for gene delivery with high transfection efficiency

(2019) Haili Wang et al.   JOURNAL OF GENE MEDICINE

Surgical and tissue engineering strategies for articular cartilage and meniscus repair

(2019) Heenam Kwon et al.   Nature Reviews Rheumatology

Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno‐Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects

(2019) Henning Madry et al.   ADVANCED MATERIALS

Internal Fixation of Osteochondritis Dissecans of the Knee Leads to Good Long-Term Outcomes and High Degree of Healing without Differences between Fixation Devices

(2019) Simone Perelli et al.   Journal of Clinical Medicine

Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs

(2018) Christopher R. Rowland et al.   BIOMATERIALS

Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus–Mediated SOX9 Gene Transfer

(2018) Jagadeesh K. Venkatesan et al.   HUMAN GENE THERAPY

Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication

(2018) Indong Jun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair

(2018) Rosanne M. Raftery et al.   JOURNAL OF CONTROLLED RELEASE

Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications

(2018) Siddharth Patel et al.   TISSUE ENGINEERING PART A

Efficacy of Octacalcium Phosphate Collagen Composite for Titanium Dental Implants in Dogs

(2018) Tadashi Kawai et al.   Materials

Animal models used for testing hydrogels in cartilage regeneration

(2018) Chuntie Zhu et al.   Current Stem Cell Research & Therapy

3D Printing and Electrospinning of Composite Hydrogels for Cartilage and Bone Tissue Engineering

(2018) Arianna De Mori et al.   Polymers

Current state of fabrication technologies and materials for bone tissue engineering

(2018) Abiy Wubneh et al.   Acta Biomaterialia

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment

(2018) Jagadeesh Venkatesan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

(2018) Magali Cucchiarini et al.   Nature Reviews Rheumatology

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

(2017) Ana Rey-Rico et al.   International Journal of Nanomedicine

Tailoring biomaterial scaffolds for osteochondral repair

(2017) Sandra Camarero-Espinosa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model

(2017) Behnoush Khorsand et al.   JOURNAL OF CONTROLLED RELEASE

Modified mRNA for BMP-2 in Combination with Biomaterials Serves as a Transcript-Activated Matrix for Effectively Inducing Osteogenic Pathways in Stem Cells

(2017) Elizabeth R. Balmayor et al.   STEM CELLS AND DEVELOPMENT

Non-viral gene activated matrices for mesenchymal stem cells based tissue engineering of bone and cartilage

(2016) Sophie Raisin et al.   BIOMATERIALS

Effect of sustained PDGF nonviral gene delivery on repair of tooth-supporting bone defects

(2016) A B Plonka et al.   GENE THERAPY

Chitosan based biocomposite scaffolds for bone tissue engineering

(2016) S. Saravanan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cationized gelatin hydrogels mixed with plasmid DNA induce stronger and more sustained gene expression than atelocollagen at calvarial bone defectsin vivo

(2016) K. Komatsu et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Accelerated bony defect healing based on chitosan thermosensitive hydrogel scaffolds embedded with chitosan nanoparticles for the delivery of BMP2 plasmid DNA

(2016) Hui Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model

(2016) Michael Keeney et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems

(2016) Mehdi Rezaee et al.   JOURNAL OF CONTROLLED RELEASE

Characterization and cytocompatibility of thermosensitive hydrogel embedded with chitosan nanoparticles for delivery of bone morphogenetic protein-2 plasmid DNA

(2016) Dan-Dan Li et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives

(2016) José Eduardo Vargas et al.   Journal of Translational Medicine

Early osteoarthritis of the knee

(2016) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing

(2016) Franklin T. Moutos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering

(2016) Tomas Gonzalez-Fernandez et al.   TISSUE ENGINEERING PART A

PEO–PPO–PEO micelles as effective rAAV-mediated gene delivery systems to target human mesenchymal stem cells without altering their differentiation potency

(2015) Ana Rey-Rico et al.   Acta Biomaterialia

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1

(2015) Hyun Joo Yoon et al.   BMC MUSCULOSKELETAL DISORDERS

Carboxymethylcellulose (CMC) formed nanogels with branched poly(ethyleneimine) (bPEI) for inhibition of cytotoxicity in human MSCs as a gene delivery vehicles

(2015) Han Na Yang et al.   CARBOHYDRATE POLYMERS

A Pilot Study Evaluating Combinatorial and Simultaneous Delivery of Polyethylenimine-Plasmid DNA Complexes Encoding for VEGF and PDGF for Bone Regeneration in Calvarial Bone Defects

(2015) Sheetal D'Mello et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

(2015) J Frisch et al.   GENE THERAPY

The grafting of a thin layer of poly(sodium styrene sulfonate) onto poly(ε-caprolactone) surface can enhance fibroblast behavior

(2015) Géraldine Rohman et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm

(2015) Guang Yang et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Human Articular Cartilage Progenitor Cells Are Responsive to Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone-Morphogenetic Protein 2

(2015) Alexander J. Neumann et al.   PLoS One

Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2

(2014) Clark J. Needham et al.   Acta Biomaterialia

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

(2014) Katherine A. Glass et al.   BIOMATERIALS

Impact of DNA Vector Topology on Non-Viral Gene Therapeutic Safety and Efficacy

(2014) Chi Sum et al.   CURRENT GENE THERAPY

Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications

(2014) Zibiao Li et al.   Materials Science & Engineering C-Materials for Biological Applications

Poly(lactide-co-glycolide)/Fibrin Gel Construct as a 3D Model to Evaluate Gene Therapy of Cartilage in Vivo

(2014) Bo Li et al.   MOLECULAR PHARMACEUTICS

Demineralized Bone Matrix Combined Bone Marrow Mesenchymal Stem Cells, Bone Morphogenetic Protein-2 and Transforming Growth Factor-β3 Gene Promoted Pig Cartilage Defect Repair

(2014) Xin Wang et al.   PLoS One

Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage

(2014) Jonathan M. Brunger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinspired Scaffolds for Osteochondral Regeneration

(2014) Silvia Lopa et al.   TISSUE ENGINEERING PART A

Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold

(2014) Caroline M. Curtin et al.   Advanced Healthcare Materials

DNA Ministrings: Highly Safe and Effective Gene Delivery Vectors

(2014) Nafiseh Nafissi et al.   Molecular Therapy-Nucleic Acids

The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor

(2013) Satheesh Elangovan et al.   BIOMATERIALS

Fabrication of poly(lactide-co-glycolide) scaffold filled with fibrin gel, mesenchymal stem cells, and poly(ethylene oxide)-b-poly(L-lysine)/TGF-β1 plasmid DNA complexes for cartilage restorationin vivo

(2013) Bo Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Endogenous versus exogenous growth factor regulation of articular chondrocytes

(2013) Shuiliang Shi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure

(2013) Chia-Hsin Lu et al.   MOLECULAR THERAPY

Gene delivery techniques for adult stem cell-based regenerative therapy

(2013) Seog-Jin Seo et al.   Nanomedicine

Mesenchymal stem cells in joint disease and repair

(2013) Frank Barry et al.   Nature Reviews Rheumatology

Porous Chitosan Scaffolds with Embedded Hyaluronic Acid/Chitosan/Plasmid-DNA Nanoparticles Encoding TGF-β1 Induce DNA Controlled Release, Transfected Chondrocytes, and Promoted Cell Proliferation

(2013) Huading Lu et al.   PLoS One

The potential of gene transfer for the treatment of osteoarthritis

(2013) Magali Cucchiarini et al.   Regenerative Medicine

Chondrogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Modulated by Complex Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone Morphogenetic Protein 2

(2013) Alexander J. Neumann et al.   TISSUE ENGINEERING PART A

Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer

(2013) Idalia Garza-Veloz et al.   ARTHRITIS RESEARCH & THERAPY

Porous bioprinted constructs in BMP-2 non-viral gene therapy for bone tissue engineering

(2013) Loek D. Loozen et al.   Journal of Materials Chemistry B

TGF-β1 gene-engineered mesenchymal stem cells induce rat cartilage regeneration using nonviral gene vector

(2012) Cai-Xia He et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Critical size defect regeneration using PEG-mediated BMP-2 gene delivery and the use of cell occlusive barrier membranes - the osteopromotive principle revisited

(2012) Falk Wehrhan et al.   CLINICAL ORAL IMPLANTS RESEARCH

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Osteochondral tissue engineering: scaffolds, stem cells and applications

(2012) Patcharakamon Nooeaid et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model

(2012) Fiona Wegman et al.   Journal of Tissue Engineering and Regenerative Medicine

Reconstruct large osteochondral defects of the knee with hIGF-1 gene enhanced Mosaicplasty

(2012) Ping Leng et al.   KNEE

The promotion of cartilage defect repair using adenovirus mediated Sox9 gene transfer of rabbit bone marrow mesenchymal stem cells

(2011) Lei Cao et al.   BIOMATERIALS

Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds

(2011) Jiangning Chen et al.   BIOMATERIALS

SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat

(2011) Jong-Min Lee et al.   BIOMATERIALS

The Role of Growth Factors in Cartilage Repair

(2011) Lisa A. Fortier et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The Sleeping Beauty transposon system: a non-viral vector for gene therapy

(2011) E. L. Aronovich et al.   HUMAN MOLECULAR GENETICS

Occurrence, biochemical profile of vascular endothelial growth factor (VEGF) isoforms and their functions in endochondral ossification

(2011) A.S. Patil et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds

(2011) Erica G. Tierney et al.   JOURNAL OF CONTROLLED RELEASE

Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review

(2011) Tapan K. Dash et al.   JOURNAL OF CONTROLLED RELEASE

Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer

(2011) Shuiliang Shi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs

(2011) Arnold I. Caplan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee

(2011) Martina Schinhan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

(2011) M.I. Menendez et al.   OSTEOARTHRITIS AND CARTILAGE

IGF-1 and BMP-2 Induces Differentiation of Adipose-Derived Mesenchymal Stem Cells into Chondrocytes-Like Cells

(2010) Chunhou An et al.   ANNALS OF BIOMEDICAL ENGINEERING

In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes

(2010) Wei Wang et al.   BIOMATERIALS

Localized Delivery of Antisense Oligonucleotides by Cationic Hydrogel Suppresses TNF-α Expression and Endotoxin-Induced Osteolysis

(2010) Lei Dong et al.   PHARMACEUTICAL RESEARCH

Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells

(2009) Seiji Kubo et al.   ARTHRITIS AND RHEUMATISM

Adenoviral transduction of hTGF-β1 enhances the chondrogenesis of bone marrow derived stromal cells

(2009) Wanyao Xia et al.   BIOTECHNOLOGY LETTERS

Calcium phosphate-DNA nanoparticle gene delivery from alginate hydrogels inducesin vivoosteogenesis

(2009) Melissa D. Krebs et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Osteochondral Junction and Its Repair via Bi-Phasic Tissue Engineering Scaffolds

(2009) Michael Keeney et al.   TISSUE ENGINEERING PART B-REVIEWS

Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus Microfracture

(2008) Daniel B. F. Saris et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair

(2008) Xin Zhang et al.   BIOMATERIALS

The repair of osteochondral defects using baculovirus-mediated gene transfer with de-differentiated chondrocytes in bioreactor culture

(2008) Huang-Chi Chen et al.   BIOMATERIALS