Stem cell therapy for Alzheimer's disease

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

(2020) Renaud La Joie et al.   Science Translational Medicine

Therapeutic strategies targeting amyloid-β in Alzheimer’s disease

(2019) Lídia Pinheiroa et al.   Current Alzheimer Research

Extracellular Vesicles from Mesenchymal Stem Cells Exert Pleiotropic Effects on Amyloid‐β, Inflammation, and Regeneration: A Spark of Hope for Alzheimer's Disease from Tiny Structures?

(2019) Chiara A. Elia et al.   BIOESSAYS

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

(2019) Charles Arber et al.   MOLECULAR PSYCHIATRY

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

(2018) Jacques Galipeau et al.   Cell Stem Cell

Changing Paradigm from one Target one Ligand Towards Multi-target Directed Ligand Design for Key Drug Targets of Alzheimer Disease: An Important Role of In Silico Methods in Multi-target Directed Ligands Design

(2018) Akhil Kumar et al.   Current Neuropharmacology

Stem cell-based cell therapy for neuroprotection in stroke: A review

(2018) Reza Rikhtegar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Advances in developing novel therapeutic strategies for Alzheimer’s disease

(2018) Jiqing Cao et al.   Molecular Neurodegeneration

A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease

(2017) Yihong Zhan et al.   NEUROBIOLOGY OF AGING

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells

(2017) Nicholas Brookhouser et al.   Cells

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease

(2016) Lidia Bakota et al.   DRUGS

Novel strategies for Alzheimer's disease treatment: An overview of anti-amyloid beta monoclonal antibodies

(2016) Katarzyna Rygiel   INDIAN JOURNAL OF PHARMACOLOGY

Stem Cell Therapy for Alzheimer’s Disease: A Review of Recent Clinical Trials

(2016) Jae Myeong Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

(2016) Weiguo Peng et al.   NEUROBIOLOGY OF DISEASE

Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice

(2016) Y. Naaldijk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Application of Pluripotent Stem Cells

(2016) Laia Tolosa et al.   TRANSPLANTATION

Human Neural Stem Cell Transplantation Rescues Cognitive Defects in APP/PS1 Model of Alzheimer’s Disease by Enhancing Neuronal Connectivity and Metabolic Activity

(2016) Xueyuan Li et al.   Frontiers in Aging Neuroscience

Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2016) Moon-Yong Cha et al.   Stem Cells Translational Medicine

Stem Cell Therapy and Immunological Rejection in Animal Models

(2016) Xiaowei Jin et al.   Current Molecular Pharmacology

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

Effective drug therapy for Alzheimer's disease remains elusive

(2015) K. Traynor   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

(2015) Stephanie J. B. Vos et al.   BRAIN

Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy

(2015) Dah-Ching Ding et al.   CELL TRANSPLANTATION

Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Neuronal Differentiation by Enhancing the Wnt Signaling Pathway in an Alzheimer's Disease Model

(2015) Se Hee Oh et al.   CELL TRANSPLANTATION

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

(2015) Rahasson R. Ager et al.   HIPPOCAMPUS

Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

(2015) Juan Xiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease

(2015) Qi Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

(2015) Il-Shin Lee et al.   Molecular Neurodegeneration

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells

(2015) Daniel Paull et al.   NATURE METHODS

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke

(2015) Auston Eckert et al.   Stem Cells Translational Medicine

Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergicα7 Nicotinic Receptor Drugs

(2015) Anna M. Lilja et al.   NEURAL PLASTICITY

ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models

(2015) Wei Yue et al.   Stem Cell Reports

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

The Nature of Embryonic Stem Cells

(2014) Graziano Martello et al.   Annual Review of Cell and Developmental Biology

Progress toward the development of in vitro model system for chemical-induced developmental neurotoxicity: potential applicability of stem cells

(2014) V. Kumar et al.   ARCHIVES OF TOXICOLOGY

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Effects of Silica and Titanium Oxide Particles on a Human Neural Stem Cell Line: Morphology, Mitochondrial Activity, and Gene Expression of Differentiation Markers

(2014) Kouki Fujioka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2

(2014) Koutaro Takamatsu et al.   Stem Cell Research

Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation

(2014) Tae-Gon Kim et al.   STEM CELLS

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

(2014) Vasiliki Mahairaki et al.   STEM CELLS AND DEVELOPMENT

Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

(2014) Mathew Blurton-Jones et al.   Stem Cell Research & Therapy

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer’s disease

(2014) Karina O. Garcia et al.   Frontiers in Aging Neuroscience

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

(2014) Gary P Morris et al.   Acta Neuropathologica Communications

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

(2013) Cory R. Nicholas et al.   Cell Stem Cell

Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice

(2013) Dongsun Park et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

(2013) Yan Liu et al.   NATURE BIOTECHNOLOGY

Long-term immunomodulatory effect of amniotic stem cells in an Alzheimer's disease model

(2013) Kyung-Sul Kim et al.   NEUROBIOLOGY OF AGING

Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase

(2013) Dongsun Park et al.   NEUROBIOLOGY OF AGING

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

Role of Nuclear Receptor on Regulation of BDNF and Neuroinflammation in Hippocampus of β-Amyloid Animal Model of Alzheimer’s Disease

(2013) Atish Prakash et al.   NEUROTOXICITY RESEARCH

Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice

(2013) Hongna Yang et al.   PLoS One

Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1–42-infused mouse model of Alzheimer’s disease

(2013) H-M Yun et al.   Cell Death & Disease

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model

(2013) Hui Yang et al.   Stem Cell Research & Therapy

The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

(2013) Grace Woodruff et al.   Cell Reports

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Human Neural Stem Cells Genetically Modified to Express Human Nerve Growth Factor (NGF) Gene Restore Cognition in the Mouse with Ibotenic Acid-Induced Cognitive Dysfunction

(2012) Hong J. Lee et al.   CELL TRANSPLANTATION

The Animal Models of Dementia and Alzheimer’s Disease for Pre-Clinical Testing and Clinical Translation

(2012) Akshay Anand et al.   Current Alzheimer Research

Self-Renewal and Differentiation of Reactive Astrocyte-Derived Neural Stem/Progenitor Cells Isolated from the Cortical Peri-Infarct Area after Stroke

(2012) I. S. Shimada et al.   JOURNAL OF NEUROSCIENCE

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases

(2012) Youssef Hibaoui et al.   Frontiers in Physiology

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

(2011) S. Nori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells

(2011) Christopher J. Bissonnette et al.   STEM CELLS

Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging

(2010) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Angiomyeloproliferative Lesions Following Autologous Stem Cell Therapy

(2010) D. Thirabanjasak et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intraarterial Autologous Implantation of Adult Stem Cells for Patients with Parkinson Disease

(2010) Augusto Brazzini et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

(2010) Oliver Cooper et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation

(2010) Hyun Ju Lee et al.   NEUROBIOLOGY OF AGING

The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease

(2010) Hyun Ju Lee et al.   NEUROSCIENCE LETTERS

Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats

(2009) Farshad Homayouni Moghadam et al.   DIFFERENTIATION

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

(2009) Ninette Amariglio et al.   PLOS MEDICINE

Mesenchymal stem cells engineered to overexpress stem cell factor improve cardiac function but have malignant potential

(2008) Shafie S. Fazel et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix

(2008) A.G. Xuan et al.   NEUROSCIENCE LETTERS

Effects of engrafted neural stem cells in Alzheimer's disease rats

(2008) A.G. Xuan et al.   NEUROSCIENCE LETTERS

Embryonic stem cell-derived neural precursor cells improve memory dysfunction in Aβ(1–40) injured rats

(2008) Jun Tang et al.   NEUROSCIENCE RESEARCH