Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

(2020) Teresa G Krieger et al.   NEURO-ONCOLOGY

A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

(2020) Kayla J. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem-Like Cells Fate in an Oxygen-Dependent Manner

(2019) Aurélie Soubéran et al.   STEM CELLS

3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics

(2019) Marcel Alexander Heinrich et al.   ADVANCED MATERIALS

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

Patient-specific 3D-printed glioblastomas

(2019) Natividad Gomez-Roman et al.   Nature Biomedical Engineering

Fabrication of 3D calcium‐alginate scaffolds for human glioblastoma modeling and anticancer drug response evaluation

(2019) Nipha Chaicharoenaudomrung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain

(2019) Zhiyun Wei et al.   Frontiers in Neuroscience

Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

(2019) Rut Tejero et al.   EBioMedicine

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

(2019) Erika Cosset et al.   Jove-Journal of Visualized Experiments

A 3D tumor spheroid model for the T98G Glioblastoma cell line phenotypic characterization

(2019) Mariam-Eleni Oraiopoulou et al.   TISSUE & CELL

Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells

(2019) Baeza-Kallee et al.   Cancers

Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema

(2019) Cameron J Herting et al.   BRAIN

Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons

(2019) Prospero Civita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

A human co‐culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics

(2019) Diana M. Leite et al.   FASEB JOURNAL

Transcriptomic Profiling of 3D Glioblastoma Tumoroids for the Identification of Mechanisms Involved in Anticancer Drug Resistance

(2019) NIPHA CHAICHAROENAUDOMRUNG et al.   IN VIVO

An advanced glioma cell invasion assay based on organotypic brain slice cultures

(2018) Tanja Eisemann et al.   BMC CANCER

Adaptive adhesion systems mediate glioma cell invasion in complex environments

(2018) Pavlo G. Gritsenko et al.   JOURNAL OF CELL SCIENCE

Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells

(2018) Ryota Kurogi et al.   JOURNAL OF NEUROSURGERY

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Neuro-inflammatory effects of photodegradative products of bilirubin

(2018) J. Jašprová et al.   Scientific Reports

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

The comparison genomics analysis with glioblastoma multiforme (GBM) cells under 3D and 2D cell culture conditions

(2018) Liang Ma et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma

(2018) Raphael Berges et al.   Cell Death & Disease

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

(2017) Pavlo Gritsenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions

(2017) Sune Munthe et al.   JOURNAL OF NEURO-ONCOLOGY

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

(2017) Jonathon J. Parker et al.   Jove-Journal of Visualized Experiments

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model

(2016) Stine Skov Jensen et al.   PLoS One

Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines

(2016) Zev A. Binder et al.   PLoS One

Origin of the U87MG glioma cell line: Good news and bad news

(2016) Marie Allen et al.   Science Translational Medicine

Systematic characterization of lncRNAs’ cell-to-cell expression heterogeneity in glioblastoma cells

(2016) Dekang Lv et al.   Oncotarget

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB

(2014) A Tchoghandjian et al.   CELL DEATH AND DIFFERENTIATION

TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways

(2014) Mingli Liu et al.   CELLULAR SIGNALLING

Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation

(2014) Alberto Azzalin et al.   JOURNAL OF NEURO-ONCOLOGY

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Belonging to a network—microRNAs, extracellular vesicles, and the glioblastoma microenvironment

(2014) Jakub Godlewski et al.   NEURO-ONCOLOGY

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

(2014) Feng Hu et al.   NEURO-ONCOLOGY

Di-Ethylhexylphthalate (DEHP) Modulates Cell Invasion, Migration and Anchorage Independent Growth through Targeting S100P in LN-229 Glioblastoma Cells

(2014) Jennifer Sims et al.   International Journal of Environmental Research and Public Health

Ex vivo cultures of glioblastoma in three-dimensional hydrogel maintain the original tumor growth behavior and are suitable for preclinical drug and radiation sensitivity screening

(2013) Carine Jiguet Jiglaire et al.   EXPERIMENTAL CELL RESEARCH

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

CRN2 enhances the invasiveness of glioblastoma cells

(2013) Anja Ziemann et al.   NEURO-ONCOLOGY

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures

(2012) Sandrine Eimer et al.   NEURO-ONCOLOGY

Cortical and Subventricular Zone Glioblastoma-Derived Stem-Like Cells Display Different Molecular Profiles and Differential In Vitro and In Vivo Properties

(2011) Aurélie Tchoghandjian et al.   ANNALS OF SURGICAL ONCOLOGY

Human Glioblastoma Stem-Like Cells are More Sensitive to Allogeneic NK and T Cell-Mediated Killing Compared with Serum-Cultured Glioblastoma Cells

(2011) Tony Avril et al.   BRAIN PATHOLOGY

Heterogeneity Maintenance in Glioblastoma: A Social Network

(2011) R. Bonavia et al.   CANCER RESEARCH

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

(2011) Erika Pastrana et al.   Cell Stem Cell

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Oct-3/4 promotes migration and invasion of glioblastoma cells

(2011) Kana Kobayashi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr

(2011) Carlos A Fedrigo et al.   Radiation Oncology

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties

(2009) Aurélie Tchoghandjian et al.   BRAIN PATHOLOGY

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth

(2008) S. Bao et al.   CANCER RESEARCH

Genomic Changes and Gene Expression Profiles Reveal That Established Glioma Cell Lines Are Poorly Representative of Primary Human Gliomas

(2008) A. Li et al.   MOLECULAR CANCER RESEARCH

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY