Article
Biochemistry & Molecular Biology
Kenji Ono, Junpei Sato, Hiromi Suzuki, Makoto Sawada
Summary: Extracellular vesicles, including microvesicles and exosomes, are involved in intercellular signaling by delivering functional molecules. This study demonstrated the presence of signal peptide (SP) fragments from human placental secreted alkaline phosphatase (SEAP) in both microvesicles (LEV) and exosomes (SEV). The content of SEAP SP fragments in LEV and SEV was influenced by cellular activation, and calmodulin was found to be involved in their transportation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang, Huijun Chen, Zishuo Guo, Xiaosheng He
Summary: TBI is a disease with high morbidity and disability worldwide, despite ongoing neural protection efforts. Due to patient heterogeneity, it is difficult to achieve satisfying results in clinic. Neuroinflammation appears since primary injury occurs, and recent studies suggest NSCs play a central role in neural regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Andrea Bianconi, Gelsomina Aruta, Francesca Rizzo, Luca Francesco Salvati, Pietro Zeppa, Diego Garbossa, Fabio Cofano
Summary: This article summarizes the latest research on the interaction between non-neoplastic cells and tumor cells in the glioma microenvironment, focusing on resident microglia, tumor-associated macrophages, lymphocytes, and extracellular vesicles. It also provides updates on new therapeutic strategies targeting immune system receptors and soluble factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jorge Sanz-Ros, Cristina Mas-Bargues, Nekane Romero-Garcia, Javier Huete-Acevedo, Mar Dromant, Consuelo Borras
Summary: Aging is associated with changes in intercellular communication, and extracellular vesicles (EVs) play an important role in these changes. EVs regulate the aging process, promote tissue regeneration, and have potential as a cell-free therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Catherine Hering, Ashok K. Shetty
Summary: This review discusses the therapeutic efficacy of extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs), and microglia (MDEVs) in traumatic brain injury (TBI) models. NSC-EV or ADEV therapy has been shown to mediate neuroprotective effects and improve motor and cognitive function after TBI. However, the therapeutic effects of naive MDEVs are yet to be tested rigorously in TBI models.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lorena R. Lizarraga-Valderrama, Graham K. Sheridan
Summary: Neurons and glial cells release EVs to the interstitial fluid of the CNS, containing proteins, nucleic acids, and lipids that modulate the behavior of recipient cells. The mechanisms of EV-mediated neuron-glial communication under physiological conditions or healthy aging are not yet clear, but proteomic studies suggest potential for targeted therapies against debilitating neurological disorders.
Review
Biochemistry & Molecular Biology
Davide Marangon, Juliana Helena Castro e Silva, Davide Lecca
Summary: Extracellular vesicles (EVs) play a crucial role in cell communication in the central nervous system (CNS). They contain and transfer complex molecular cargoes, including non-coding RNAs, which act as regulators of CNS functions and pathologies. Recent studies have shown the potential of EV-derived ncRNAs for neurorepair and their role in regulating glia activation and neuronal survival. EV-derived ncRNAs can either propagate neuroinflammatory waves or promote reparative functions in the CNS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Myriam Catalano, Carmela Serpe, Cristina Limatola
Summary: Microglial-derived extracellular vesicles (EVs) play important roles in glioblastoma, contributing to tumor growth and invasion by modifying cellular phenotype and activity. These EVs may serve as important diagnostic markers and therapeutic targets, but further research is needed to fully understand their biological effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nunzio Vicario, Rosalba Parenti
Summary: This article discusses the important role of connexins in the neurovascular unit, emphasizing their critical influence on functional processes in the nervous microenvironment in both healthy and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rephael Nizar, Simona Cazacu, Cunli Xiang, Matan Krasner, Efrat Barbiro-Michaely, Doron Gerber, Jonathan Schwartz, Iris Fried, Shira Yuval, Aharon Brodie, Gila Kazimirsky, Naama Amos, Ron Unger, Stephen Brown, Lisa Rogers, Donald H. Penning, Chaya Brodie
Summary: Glioblastoma (GBM) is a highly aggressive primary brain tumor, and glioma stem cells (GSCs) play a crucial role in tumor resistance and recurrence. Propofol, a general anesthetic, has been found to have anti-tumor effects on GSCs and improve patient prognosis. This study investigated the molecular mechanisms of propofol's effects on GSCs, including its ability to sensitize cells to radiation and temozolomide (TMZ), and researched its inhibition of the pro-tumorigenic interaction between GSCs and microglia cells via transfer of the lncRNA BDNF-AS through extracellular vesicles (EVs).
Article
Immunology
Sanooj Soni, Kieran P. O'Dea, Eiko Abe, Maryam Khamdan, Sneh V. Shah, Padmini Sarathchandra, Michael R. Wilson, Masao Takata
Summary: The study shows that the internalization of microvesicles (MVs) in the alveolar space can be modulated by different environmental conditions, with inflammatory stimuli enhancing epithelial cell uptake of MVs and inducing epithelial cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sarah A. Walsh, Benjamin W. Hoyt, Cassie J. Rowe, Devaveena Dey, Thomas A. Davis
Summary: Severe polytraumatic injury can lead to immune dysfunction, but early biomarkers for immune dysfunction are currently lacking. Study of exosomal cargo may provide critical insights for intervention.
Review
Cell Biology
Fumihiko Urabe, Kalyani Patil, Grant A. Ramm, Takahiro Ochiya, Carolina Soekmadji
Summary: Distant organ metastasis, orchestrated by complex biological interactions, is a fundamental feature of malignant tumors. Extracellular vesicles (EVs) play a critical role in mediating tumor-host cell interactions, controlling organ-specific infiltration, adaptation, and colonization at the secondary site.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Cell Biology
Yuyun Jiang, Xi Liu, Jixian Ye, Yongbin Ma, Jiahui Mao, Dingqi Feng, Xuefeng Wang
Summary: This review summarizes the discovery, formation mechanisms, isolation, identification, and mediation of cellular communication in migrasomes, which are newly discovered extracellular vesicles. In addition to their roles in various biological processes, migrasomes have been found to play a significant role in mediating different pathological processes. The potential of migrasomes for disease diagnosis and treatment is also discussed.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Engineering, Biomedical
Yitian Du, Zhenzhen Yang, Qi Sun, Meng Lin, Rudong Wang, Yiwei Peng, Xinyi Chen, Xianrong Qi
Summary: This study demonstrated the use of engineered microglia as transport vectors to deliver paclitaxel for the treatment of glioma. Engineered microglia can cross the BBB, migrate towards gliomas, and transfer cargo to glioma cells. Extracellular vesicles and tunneling nanotubes were found to play unique roles in cargo transportation between microglia and glioma cells.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Saumya Das, K. Mark Ansel, Markus Bitzer, Xandra O. Breakefield, Alain Charest, David J. Galas, Mark B. Gerstein, Mihir Gupta, Aleksandar Milosavljevic, Michael T. McManus, Tushar Patel, Robert L. Raffai, Joel Rozowsky, Matthew E. Roth, Julie A. Saugstad, Kendall Van Keuren-Jensen, Alissa M. Weaver, Louise C. Laurent, Asim B. Abdel-Mageed, Catherine Adamidi, P. David Adelson, Kemal M. Akat, Eric Alsop, Jorge Arango, Neil Aronin, Seda Kilinc Avsaroglu, Azadeh Azizian, Leonora Balaj, Iddo Z. Ben-Dov, Karl Bertram, Robert Blelloch, Kimberly A. Bogardus, Xandra Owens Breakefield, George A. Calin, Bob S. Carter, Al Charest, Clark C. Chen, Tanuja Chitnis, Robert J. Coffey, Amanda Courtright-Lim, Amrita Datta, Peter DeHoff, Thomas G. Diacovo, David J. Erle, Alton Etheridge, Marc Ferrer, Jeffrey L. Franklin, Jane E. Freedman, Timur Galeev, Roopali Gandhi, Aitor Garcia, Mark Bender Gerstein, Vikas Ghai, Ionita Calin Ghiran, Maria D. Giraldez, Andrei Goga, Tasos Gogakos, Beatrice Goilav, Stephen J. Gould, Peixuan Guo, Fred Hochberg, Bo Huang, Matt Huentelman, Craig Hunter, Elizabeth Hutchins, Andrew R. Jackson, M. Yashar S. Kalani, Pinar Kanlikilicer, Reka Agnes Karaszti, Anastasia Khvorova, Yong Kim, Hogyoung Kim, Taek Kyun Kim, Robert Kitchen, Richard P. Kraig, Anna M. Krichevsky, Raymond Y. Kwong, Minyoung Lee, Noelle L'Etoile, Shawn E. Levy, Feng Li, Jenny Li, Xin Li, Gabriel Lopez-Berestein, Rocco Lucero, Bogdan Mateescu, A. C. Matin, Klaas E. A. Max, Thorsten R. Mempel, Cindy Meyer, Debasis Mondal, Kenneth Jay Mukamal, Oscar D. Murillo, Thangamani Muthukumar, Deborah A. Nickerson, Christopher J. O'Donnell, Dinshaw J. Patel, James G. Patton, Anu Paul, Elaine R. Peskind, Mitch A. Phelps, Chaim Putterman, Peter J. Quesenberry, Joseph F. Quinn, Saritha Ranabothu, Shannon Jiang Rao, Cristian Rodriguez-Aguayo, Anthony Rosenzweig, Marc S. Sabatine, Nikita A. Sakhanenko, Julie Anne Saugstad, Thomas D. Schmittgen, Neethu Shah, Ravi Shah, Kerby Shedden, Jian Shi, Anil K. Sood, Anuoluwapo Sopeyin, Ryan M. Spengler, Robert Spetzler, Srimeenakshi Srinivasan, Sai Lakshmi Subramanian, Manikkam Suthanthiran, Kahraman Tanriverdi, Yun Teng, Muneesh Tewari, William Thistlethwaite, Thomas Tuschl, Karolina Kaczor Urbanowicz, Kasey C. Vickers, Olivier Voinnet, Kai Wang, Zhiyun Wei, Howard L. Weiner, Zachary R. Weiss, Zev Williams, David T. W. Wong, Prescott G. Woodruff, Xinshu Xiao, Irene K. Yan, Ashish Yeri, Bing Zhang, Huang-Ge Zhang
Article
Cell Biology
Aron Gyuris, Jose Navarrete-Perea, Ala Jo, Simona Cristea, Shuang Zhou, Kyle Fraser, Zhiyun Wei, Anna M. Krichevsky, Ralph Weissleder, Hakho Lee, Steve P. Gygi, Al Charest
Article
Neurosciences
Zhiyun Wei, Xingjun Meng, Rachid El Fatimy, Bowen Sun, Dongmei Mai, Junfang Zhang, Ramil Arora, Ailiang Zeng, Pingyi Xu, Shaogang Qu, Anna M. Krichevsky, Dennis J. Selkoe, Shaomin Li
NEUROBIOLOGY OF DISEASE
(2020)
Article
Cell Biology
Rocco Lucero, Valentina Zappulli, Alessandro Sammarco, Oscar D. Murillo, Pike See Cheah, Srimeenakshi Srinivasan, Eric Tai, David T. Ting, Zhiyun Wei, Matthew E. Roth, Louise C. Laurent, Anna M. Krichevsky, Xandra O. Breakefield, Aleksandar Milosavljevic
Review
Neurosciences
Agathe Duchateau, Aurelie de Thonel, Rachid El Fatimy, Veronique Dubreuil, Valerie Mezger
NEUROSCIENCE LETTERS
(2020)
Article
Multidisciplinary Sciences
Ailiang Zeng, Zhiyun Wei, Rosalia Rabinovsky, Hyun Jung Jun, Rachid El Fatimy, Evgeny Deforzh, Ramil Arora, Yizheng Yao, Shun Yao, Wei Yan, Erik J. Uhlmann, Alain Charest, Yongping You, Anna M. Krichevsky
Article
Oncology
Yanhong Zhang, Changli Yue, Anna M. Krichevsky, Igor Garkavtsev
Summary: This study reveals the role of stress granule-associated protein G3BP2 in regulating the immune checkpoint molecule PD-L1 in breast and glioblastoma cancer cells, suggesting a connection between stress granule formation and immune checkpoint control in cancer. Inhibition of G3BP2 leads to decreased PD-L1 expression, enhancing the immune response and improving the survival of breast tumor-bearing mice.
MOLECULAR ONCOLOGY
(2022)
Article
Clinical Neurology
Erik J. Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper, Justin M. Moore, Rafael A. Vega, Ajith J. Thomas, Ronald L. Alterman, Martina Stippler, Matthew P. Anderson, Erik N. Uhlmann, Franciela C. Kipper, Anna M. Krichevsky
Summary: Meningioma is the most common primary central nervous system tumor, which can cause serious complications by mass effect and vasogenic edema despite being mostly nonmalignant. Current treatments include surgery and radiation, but not all cases can be treated due to location. The lack of medical treatment to slow meningioma growth is attributed to incomplete understanding of the underlying pathology, resulting from the absence of high-fidelity tissue culture and animal models. The proposed method allows for the establishment of meningioma tumor-derived primary cultures, providing a more accurate tumor cell microenvironment for research and drug screening.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachid El Fatimy, Yanhong Zhang, Evgeny Deforzh, Mahalakshmi Ramadas, Harini Saravanan, Zhiyun Wei, Rosalia Rabinovsky, Nadiya M. Teplyuk, Erik J. Uhlmann, Anna M. Krichevsky
Summary: miR-10b is a key oncogene miRNA associated with malignant gliomas. However, its poorly understood properties hinder its clinical translation.
Article
Genetics & Heredity
Lien D. Nguyen, Rachel K. Chau, Anna M. Krichevsky
Summary: This article highlights the promising therapeutic strategy of targeting ncRNAs with small molecules for ADRD treatment. It outlines the process from discovery to preclinical studies of validating small molecules targeting ncRNAs, emphasizing primary high-throughput screens for lead compounds. Challenges such as selecting appropriate ncRNA targets, lack of specificity of small molecules, and the general low success rate of neurological drugs are discussed as areas to overcome in future research.
Article
Biochemistry & Molecular Biology
Evgeny Deforzh, Erik J. Uhlmann, Eashita Das, Aleksandra Galitsyna, Ramil Arora, Harini Saravanan, Rosalia Rabinovsky, Aditya D. Wirawan, Nadiya M. Teplyuk, Rachid El Fatimy, Sucika Perumalla, Anirudh Jairam, Zhiyun Wei, Leonid Mirny, Anna M. Krichevsky
Summary: miR-10b gene locus of HOXD gene cluster is activated in glioma through chromatin reorganization and CTCF-cohesin-mediated looping mechanism, which is facilitated by two interacting long non-coding RNAs (lncRNAs) - HOXD-AS2 and LINC01116.
Article
Oncology
Olivier Gevaert, Mohsen Nabian, Shaimaa Bakr, Celine Everaert, Jayendra Shinde, Artur Manukyan, Ted Liefeld, Thorin Tabor, Jishu Xu, Joachim Lupberger, Brian J. Haas, Thomas F. Baumert, Mikel Hernaez, Michael Reich, Francisco J. Quintana, Erik J. Uhlmann, Anna M. Krichevsky, Jill P. Mesirov, Vincent Carey, Nathalie Pochet
JCO CLINICAL CANCER INFORMATICS
(2020)