CoQ10 Deficient Endothelial Cell Culture Model for the Investigation of CoQ10 Blood–Brain Barrier Transport

Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

(2020) Anna Di Lorenzo et al.   Journal of Clinical Medicine

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation

(2018) Virginia Actis Dato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier

(2017) Yves Molino et al.   FASEB JOURNAL

Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

(2017) Sumit Parikh et al.   GENETICS IN MEDICINE

Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers

(2017) Misato Kashiba et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1

(2017) Karen Y. Fung et al.   Frontiers in Physiology

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency

(2017) Fabien Pierrel   Frontiers in Physiology

Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells

(2017) Simone S. E. Nielsen et al.   Jove-Journal of Visualized Experiments

Coenzyme Q biosynthesis in health and disease

(2016) Manuel Jesús Acosta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway

(2016) Marcello Ziosi et al.   EMBO Molecular Medicine

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

(2016) Jason K. Cullen et al.   PLoS One

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

(2016) Jan R. Kraehling et al.   Nature Communications

Helicobacter pylori Activates HMGB1 Expression and Recruits RAGE into Lipid Rafts to Promote Inflammation in Gastric Epithelial Cells

(2016) Hwai-Jeng Lin et al.   Frontiers in Immunology

COQ4 Mutations Cause a Broad Spectrum of Mitochondrial Disorders Associated with CoQ10 Deficiency

(2015) Gloria Brea-Calvo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PPARγ agonists regulate bidirectional transport of amyloid-β across the blood-brain barrier and hippocampus plasticity indb/dbmice

(2015) Hao Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis

(2015) Susan M. Armstrong et al.   CARDIOVASCULAR RESEARCH

Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase

(2015) Valentina González-Pecchi et al.   MICROVASCULAR RESEARCH

Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier

(2015) Danielle N. Doll et al.   STROKE

Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes

(2014) James M. May et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells

(2014) K.E. Duberley et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Treatment of Mitochondrial Disorders

(2014) Gregory M. Enns   JOURNAL OF CHILD NEUROLOGY

A detailed method for preparation of a functional and flexible blood–brain barrier model using porcine brain endothelial cells

(2013) Adjanie Patabendige et al.   BRAIN RESEARCH

Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells

(2013) Matheus Augusto de Bittencourt Pasquali et al.   CELLULAR SIGNALLING

Mitochondrial Coenzyme Q10 Determination by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry

(2013) O. Itkonen et al.   CLINICAL CHEMISTRY

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apolipoprotein E in VLDL and LDL With Apolipoprotein C‐III is Associated With a Lower Risk of Coronary Heart Disease

(2013) Carlos O. Mendivil et al.   Journal of the American Heart Association

Heterogeneity of Coenzyme Q10Deficiency

(2012) Valentina Emmanuele et al.   ARCHIVES OF NEUROLOGY

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Is RAGE still a therapeutic target for Alzheimer’s disease?

(2012) Richard J Deane   Future Medicinal Chemistry

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment

(2012) Kate E. C. Duberley et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Effects of Inhibiting CoQ10 Biosynthesis with 4-nitrobenzoate in Human Fibroblasts

(2012) Catarina M. Quinzii et al.   PLoS One

Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma

(2011) Antonio Mancini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RAGE: a single receptor fits multiple ligands

(2011) Günter Fritz   TRENDS IN BIOCHEMICAL SCIENCES

4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures

(2010) Ulrika Forsman et al.   Nature Chemical Biology

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

(2009) Shirou Itagaki et al.   FOOD CHEMISTRY

ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q10 Deficiency

(2008) Clotilde Lagier-Tourenne et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model

(2008) Fabien Gosselet et al.   BRAIN RESEARCH

Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging

(2008) Lynn A. Bialowas-McGoey et al.   GLIA

Interaction of Coenzyme Q10 with the Intestinal Drug Transporter P-Glycoprotein

(2008) Shirou Itagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes

(2008) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL