Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression

Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype

(2020) Hongliang Dong et al.   Journal for ImmunoTherapy of Cancer

The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion

(2019) Laura Pinton et al.   Journal for ImmunoTherapy of Cancer

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

MicroRNAs as Molecular Switches in Macrophage Activation

(2019) Graziella Curtale et al.   Frontiers in Immunology

Progress on Modulating Tumor‐Associated Macrophages with Biomaterials

(2019) Meilyn Sylvestre et al.   ADVANCED MATERIALS

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

(2018) Veronica Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Role of MicroRNAs in the development and function of innate immune cells

(2017) S. Manoj Kumar Kingsley et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages

(2017) Fei Huang et al.   Frontiers in Immunology

Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection

(2016) Zhen Huang et al.   BIOMATERIALS

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

(2016) Jun-Long Zhao et al.   CANCER RESEARCH

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma

(2016) Yi Zhang et al.   JOURNAL OF PATHOLOGY

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

(2016) Amra Saric et al.   MOLECULAR BIOLOGY OF THE CELL

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME)

(2016) Robert D. Petty et al.   PLoS One

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation

(2015) Lorenzo de la Rica et al.   GENOME BIOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation

(2014) Manisha Singh et al.   JOURNAL OF IMMUNOLOGY

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

Mycobacterium tuberculosisControls MicroRNA-99b (miR-99b) Expression in Infected Murine Dendritic Cells to Modulate Host Immunity

(2012) Yogesh Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

(2011) Gregory J. Tesz et al.   BIOCHEMICAL JOURNAL

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells

(2011) A. Gerrits et al.   BLOOD

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY