Recent Advances in Construction of Polycyclic Natural Product Scaffolds via One-Pot Reactions Involving Alkyne Annulation

Acetylene as a Dicarbene Equivalent for Gold(I) Catalysis: Total Synthesis of Waitziacuminone in One Step

(2020) Dagmar Scharnagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Study on Gold-Catalyzed Cycloisomerization of Dienediynes Involving Aliphatic C–H Functionalization and Inspiration for Developing a New Strategy to Access Polycarbocycles

(2020) Yi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-Pot Assembly of 3-Hydroxycarbazoles via Uninterrupted Propargylation/Hydroxylative Benzannulation Reactions

(2020) Chada Raji Reddy et al.   ORGANIC LETTERS

Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade

(2020) James A. Rossi-Ashton et al.   ORGANIC LETTERS

Recent advances in the development of one-pot/multistep syntheses of 3,4-annulated indoles

(2020) Robert Connon et al.   TETRAHEDRON LETTERS

In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery

(2020) Lauro Ribeiro de Souza Neto et al.   Frontiers in Chemistry

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Hydroxylamines As Bifunctional Single-Nitrogen Sources for the Rapid Assembly of Diverse Tricyclic Indole Scaffolds

(2020) Liangxin Fan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automated radial synthesis of organic molecules

(2020) Sourav Chatterjee et al.   NATURE

Total synthesis of terpenes via palladium-catalysed cyclization strategy

(2020) Barry M. Trost et al.   Nature Chemistry

Synthesis of Bridged Azacycles and Propellanes via Nitrene/Alkyne Cascades

(2020) Qinxuan Wang et al.   ORGANIC LETTERS

Directing Group Assisted Unsymmetrical Multiple Functionalization of Arene C−H Bonds

(2020) Koushik Ghosh et al.   CHEMICAL RECORD

Palladium-Catalyzed [2 + 2 + 1] Annulation of Alkyne-Tethered Aryl Iodides with Diaziridinone: Synthesis of 3,4-Fused Tricyclic Indoles

(2020) Lei Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Anhydroryanodol

(2020) Kang Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 3,4-Fused Tricyclic Indoles through Cascade Carbopalladation and C–H Amination: Development and Total Synthesis of Rucaparib

(2020) Cang Cheng et al.   ORGANIC LETTERS

Natural Products in the “Marketplace”: Interfacing Synthesis and Biology

(2019) Benjamin J. Huffman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total syntheses of dehydrobotrydienal, dehydrobotrydienol and 10-oxodehydrodihydrobotrydial

(2019) Zichun Zhang et al.   CHINESE CHEMICAL LETTERS

A General Carbazole Synthesis via Stitching of Indole–Ynones with Nitromethanes: Application to Total Synthesis of Carbazomycin A, Calothrixin B, and Staurosporinone

(2019) Shweta Singh et al.   ORGANIC LETTERS

Gold-Catalyzed Homogeneous (Cyclo)Isomerization Reactions

(2019) Marta Marín-Luna et al.   Frontiers in Chemistry

Indole Alkaloid Synthesis Facilitated by Photoredox Catalytic Radical Cascade Reactions

(2019) Xiao-Yu Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery

(2019) Xin Yang et al.   CHEMICAL REVIEWS

Synthesis of Multisubstituted 1-Naphthoic Acids via Ru-Catalyzed C–H Activation and Double-Alkyne Annulation under Air

(2019) Honghao Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Modular Access to Diverse Bridged Indole Alkaloid Mimics via a Gold-Triggered Cascade Dearomative Spirocarbocyclization/[4 + 2] Cycloaddition Sequence

(2019) Yi He et al.   ORGANIC LETTERS

Studies Targeting Ryanodol Result in an Annulation Reaction for the Synthesis of a Variety of Fused Carbocycles

(2019) Rajdip Karmakar et al.   ORGANIC LETTERS

A robotic platform for flow synthesis of organic compounds informed by AI planning

(2019) Connor W. Coley et al.   SCIENCE

Divergent Strategy in Natural Product Total Synthesis

(2018) Lei Li et al.   CHEMICAL REVIEWS

Recent Advances in [Cp*MIII ] (M = Co, Rh, Ir)-Catalyzed Intramolecular Annulation Through C-H Activation

(2018) Augustin Peneau et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chemical probes and drug leads from advances in synthetic planning and methodology

(2018) Christopher J. Gerry et al.   NATURE REVIEWS DRUG DISCOVERY

Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused Indole and Spirooxindole Derivatives

(2018) Ju Cai et al.   ORGANIC LETTERS

Dearomatization of Indole via Intramolecular [3 + 2] Cycloaddition: Access to the Pentacyclic Skeleton of Strychons Alkaloids

(2018) Zhengshen Wang et al.   ORGANIC LETTERS

From Straightforward Gold(I)-Catalyzed Enyne Cyclizations to more Demanding Intermolecular Reactions of Alkynes with Alkenes

(2018) Antonio Echavarren et al.   SYNLETT

Transition-Metal-Catalyzed Intramolecular Nucleophilic Addition of Carbonyl Groups to Alkynes

(2018) Lianfen Chen et al.   Chem

Gold-catalyzed annulations of N-aryl ynamides with benzisoxazoles to construct 6H-indolo[2,3-b]quinoline cores

(2018) Meng-Han Tsai et al.   CHEMICAL COMMUNICATIONS

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Expanding the medicinal chemistry synthetic toolbox

(2018) Jonas Boström et al.   NATURE REVIEWS DRUG DISCOVERY

Toward the Total Synthesis of Ryanodol via Oxidative Alkyne–1,3-Diketone Annulation: Construction of a Ryanoid Tetracycle

(2018) Kang Du et al.   ORGANIC LETTERS

Direct synthesis of aryl-annulated [c]carbazoles by gold(i)-catalysed cascade reaction of azide-diynes and arenes

(2018) Yuiki Kawada et al.   Chemical Science

Gold(III)-Catalyzed Site-Selective and Divergent Synthesis of 2-Aminopyrroles and Quinoline-Based Polyazaheterocycles

(2018) Zhongyi Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Total Synthesis of (+)-Strychnine

(2018) Liping He et al.   ORGANIC LETTERS

Isocanthine Synthesis via Rh(III)-Catalyzed Intramolecular C–H Functionalization

(2017) Anthony Y. Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Highly Oxygenated Carbocycles by Stereoselective Coupling of Alkynes to 1,3- and 1,4-Dicarbonyl Systems

(2017) Matthew J. Kier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies

(2017) Wenhan Zhang et al.   NATURAL PRODUCT REPORTS

Enantioselective Total Synthesis of (+)-Lysergol: A Formal anti-Carbopalladation/Heck Cascade as the Key Step

(2017) Bastian Milde et al.   ORGANIC LETTERS

Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine

(2017) Haichao Liu et al.   ORGANIC LETTERS

Gold catalysis-facilitated rapid synthesis of the daphnane/tigliane tricyclic core

(2017) Yong Li et al.   TETRAHEDRON

Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold

(2017) Wen-Bo Shen et al.   Nature Communications

One step construction of a taxane-like skeleton by a diendiyne metathesis cyclization reaction

(2017) J. Otero-Fraga et al.   Organic Chemistry Frontiers

A Radical Cascade Enabling Collective Syntheses of Natural Products

(2017) Xiaobei Wang et al.   Chem

Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery

(2016) Miguel Garcia-Castro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Catalyzed Annulations through Activation and Cleavage of C−H Bonds

(2016) Moisés Gulías et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cascade Strategy Enables a Total Synthesis of (±)-Morphine

(2016) Shuyu Chu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkenylation of Arenes and Heteroarenes with Alkynes

(2016) Vadim P. Boyarskiy et al.   CHEMICAL REVIEWS

Cascade polycyclizations in natural product synthesis

(2016) R. Ardkhean et al.   CHEMICAL SOCIETY REVIEWS

Gold catalysis in total synthesis – recent achievements

(2016) Daniel Pflästerer et al.   CHEMICAL SOCIETY REVIEWS

Cascade Metathesis Reactions for the Synthesis of Taxane and Isotaxane Derivatives

(2016) Cong Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbopalladation Cascades Using Carbon-Carbon Triple Bonds: Recent Advances to Access Complex Scaffolds

(2016) Alexander Düfert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Study of Cascade Ring-Closing Metathesis Reactions en Route to an Advanced Intermediate of Taxol

(2016) Aurélien Letort et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C–H Activation, and Alkyne Annulation

(2016) Liyao Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Hexadehydro-Diels–Alder (HDDA)-Enabled Carbazolyne Chemistry: Single Step, de Novo Construction of the Pyranocarbazole Core of Alkaloids of the Murraya koenigii (Curry Tree) Family

(2016) Tao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

A 15-step synthesis of (+)-ryanodol

(2016) K. V. Chuang et al.   SCIENCE

Pot economy and one-pot synthesis

(2016) Yujiro Hayashi   Chemical Science

Formalanti-Carbopalladation Reactions of Non-Activated Alkynes: Requirements, Mechanistic Insights, and Applications

(2015) Martin Pawliczek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Rubriflordilactone A

(2015) Shermin S. Goh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Novel Synthetic Methodologies and Reagents during Natural Product Synthesis in the Post-Palytoxin Era

(2015) Ahlam M. Armaly et al.   CHEMICAL REVIEWS

Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity

(2015) Ruth Dorel et al.   CHEMICAL REVIEWS

Direct Synthesis of Protoberberine Alkaloids by Rh-Catalyzed C−H Bond Activation as the Key Step

(2015) Jayachandran Jayakumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rh(I)-Catalyzed Chemo- and Stereoselective Domino Cycloaddition of Optically Active Propargyl 2,4-Hexadienyl Ethers

(2015) Jun Ying et al.   JOURNAL OF ORGANIC CHEMISTRY

Hydrazone-Initiated Carbene/Alkyne Cascades to Form Polycyclic Products: Ring-Fused Cyclopropenes as Mechanistic Intermediates

(2015) Phong Q. Le et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

(2015) Christoph Heinz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lessons from the Synthetic Chemist Nature

(2015) Gerrit Jürjens et al.   NATURAL PRODUCT REPORTS

Molecular Complexity from Polyunsaturated Substrates: The Gold Catalysis Approach

(2014) Louis Fensterbank et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold(I) as an Artificial Cyclase: Short Stereodivergent Syntheses of (−)-Epiglobulol and (−)-4β,7α- and (−)-4α,7α-Aromadendranediols

(2014) Javier Carreras et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Natural-Product-Derived Chemical Toolbox for Modulation of Protein Function

(2014) Stefano Rizzo et al.   CHEMICAL REVIEWS

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

A Facile Asymmetric Approach to the Multicyclic Core Structure of Mangicol A

(2014) Jun Ying et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium(III)-Catalyzed CH Activation and Indole Synthesis With Hydrazone as an Auto-Formed and Auto-Cleavable Directing Group

(2014) Liyao Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Ascididemin-Type Alkaloids Using Alkyne Building Blocks

(2014) Hao Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Modular Assembly of Ring-Fused and π-Extended Phenanthroimidazoles via C–H Activation and Alkyne Annulation

(2014) Liyao Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

(2014) Jonghoon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategic innovation in the total synthesis of complex natural products using gold catalysis

(2014) Yun Zhang et al.   NATURAL PRODUCT REPORTS

Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C–H Activation

(2014) Pei-Jun Cai et al.   ORGANIC LETTERS

Chemicals from Alkynes with Palladium Catalysts

(2013) Rafael Chinchilla et al.   CHEMICAL REVIEWS

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

(2013) Anton V. Gulevich et al.   CHEMICAL REVIEWS

Recent Advances in Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon–Carbon Multiple Bonds

(2013) Xiaoming Zeng   CHEMICAL REVIEWS

“Two Functional Groups in One Package”: Using Both Alkyne π-Bonds in Cascade Transformations

(2013) Igor V. Alabugin et al.   JOURNAL OF ORGANIC CHEMISTRY

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

(2013) Haruki Mizoguchi et al.   Nature Chemistry

A robustness screen for the rapid assessment of chemical reactions

(2013) Karl D. Collins et al.   Nature Chemistry

Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to  -lactam antibiotics

(2013) J. D. Podoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis

(2012) Jeffrey S. Cannon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Diversity-Oriented Approach to Spiroindolines: Post-Ugi Gold-Catalyzed Diastereoselective Domino Cyclization

(2012) Sachin G. Modha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products (Chem. Eur. J. 31/2012)

(2012) David Y.-K. Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Isoquinolines and Heterocycle-Fused Pyridines via Three-Component Cascade Reaction of Aryl Ketones, Hydroxylamine, and Alkynes

(2012) Liyao Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Bridged Polycyclic Ring Systems via Carbene Cascades Terminating in C–H Bond Insertion

(2012) Santa Jansone-Popova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The hexadehydro-Diels–Alder reaction

(2012) Thomas R. Hoye et al.   NATURE

Enantioselective Gold-Catalyzed Synthesis of Polycyclic Indolines

(2012) Gianpiero Cera et al.   ORGANIC LETTERS

Formal Asymmetric Synthesis of Echinopine A and B

(2011) Philippe A. Peixoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclizations of Alkynes: Revisiting Baldwin’s Rules for Ring Closure

(2011) Kerry Gilmore et al.   CHEMICAL REVIEWS

Collective synthesis of natural products by means of organocascade catalysis

(2011) Spencer B. Jones et al.   NATURE

Scalable enantioselective total synthesis of taxanes

(2011) Abraham Mendoza et al.   Nature Chemistry

Synthesis of the Tricyclic Core of Aldingenin B by Oxidative Cyclo-Ketalization of an Alkyne-Diol

(2011) Jingyue Yang et al.   ORGANIC LETTERS

Enantioselective Synthesis of (−)-Englerins A and B

(2010) Kian Molawi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric, Protecting-Group-Free Total Synthesis of (−)-Englerin A

(2010) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aiming for the Ideal Synthesis

(2010) Tanja Gaich et al.   JOURNAL OF ORGANIC CHEMISTRY

Gold(I)-Catalyzed Enantioselective Polycyclization Reactions

(2010) Steven G. Sethofer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold(I)-Catalyzed Tandem Cyclization Approach to Tetracyclic Indolines

(2010) Yongxiang Liu et al.   ORGANIC LETTERS

Natural Product Synthesis Using Multicomponent Reaction Strategies

(2009) Barry B. Touré et al.   CHEMICAL REVIEWS

Gold and platinum catalysis—a convenient tool for generating molecular complexity

(2009) Alois Fürstner   CHEMICAL SOCIETY REVIEWS

Gold-Catalyzed Organic Transformations

(2008) Zigang Li et al.   CHEMICAL REVIEWS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH