Lessons from the Synthetic Chemist Nature

A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

(2014) David R. Snead et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis

(2014) Mikail E. Abbasov et al.   NATURAL PRODUCT REPORTS

Toward the ideal synthesis and molecular function through synthesis-informed design

(2014) Paul A. Wender   NATURAL PRODUCT REPORTS

Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

(2014) Eric M. Woerly et al.   Nature Chemistry

Continuous Flow Total Synthesis of Rufinamide

(2014) Ping Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis

(2013) Wei Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of 6-Deoxyerythronolide B via C–C Bond-Forming Transfer Hydrogenation

(2013) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlling stereochemistry in polyketide synthesis: 1,3- vs. 1,2-asymmetric induction in methyl ketone aldol additions to β-super siloxy aldehydes

(2013) Patrick B. Brady et al.   Chemical Science

Synthesis of Tetrasubstituted Alkenes through a Palladium-Catalyzed Domino Carbopalladation/CH-Activation Reaction

(2012) Lutz F. Tietze et al.   CHEMISTRY-A EUROPEAN JOURNAL

Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis

(2012) Barbara T. Ueberbacher et al.   NATURAL PRODUCT REPORTS

Terpenoid synthase structures: a so far incomplete view of complex catalysis

(2012) Yang Gao et al.   NATURAL PRODUCT REPORTS

Total Synthesis of Synechoxanthin through Iterative Cross-Coupling

(2011) Seiko Fujii et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Total Syntheses Utilizing “Supersilyl” Chemistry

(2011) Brian J. Albert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Biosynthesis via carbocations: Theoretical studies on terpene formation

(2011) Dean J. Tantillo   NATURAL PRODUCT REPORTS

Lessons and revelations from biomimetic syntheses

(2011) Mina Razzak et al.   Nature Chemical Biology

A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling

(2010) Suk Joong Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Triple-Aldol Cascade Reaction for the Rapid Assembly of Polyketides

(2010) Brian J. Albert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicatalysis: Advancing Synthetic Efficiency and Inspiring Discovery

(2010) Lisa M. Ambrosini et al.   ChemCatChem

Enantioselective Synthesis of Cyclopentene Carbaldehydes by a Direct Multicatalytic Cascade Sequence: Carbocyclization of Aldehydes with Alkynes

(2010) Kim L. Jensen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aiming for the Ideal Synthesis

(2010) Tanja Gaich et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoretentive Suzuki−Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (−)-Peridinin

(2010) Eric M. Woerly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclization of aromatic polyketides from bacteria and fungi

(2010) Hui Zhou et al.   NATURAL PRODUCT REPORTS

New insights into the formation of fungal aromatic polyketides

(2010) Jason M. Crawford et al.   NATURE REVIEWS MICROBIOLOGY

Resistance to and synthesis of the antibiotic mupirocin

(2010) Christopher M. Thomas et al.   NATURE REVIEWS MICROBIOLOGY

Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis

(2010) Dhevalapally B. Ramachary et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Continuous-Flow Synthesis of Ibuprofen

(2009) Andrew R. Bogdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Economy in Organic Synthesis

(2009) Noah Z. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis at the molecular frontier

(2009) Paul A. Wender et al.   NATURE

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Lessons from Nature: Biomimetic Organocatalytic Carbon−Carbon Bond Formations§

(2008) Dieter Enders et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantiospecific Total Synthesis of the Hapalindoles, Fischerindoles, and Welwitindolinonesviaa Redox Economic Approach

(2008) Jeremy M. Richter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in biomimetic natural product synthesis

(2008) Paul G. Bulger et al.   NATURAL PRODUCT REPORTS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling

(2007) Suk Joong Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY