Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4

MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics

(2017) Pathricia V. Tilstam et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions

(2016) Deepa Rajasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

(2016) Yi Zheng et al.   NATURE

Intracellular allosteric antagonism of the CCR9 receptor

(2016) Christine Oswald et al.   NATURE

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly

(2015) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

An Analysis of MIF Structural Features that Control Functional Activation of CD74

(2015) Georgios Pantouris et al.   CHEMISTRY & BIOLOGY

Targeting chemokines: Pathogens can, why can’t we?

(2015) Amanda E.I. Proudfoot et al.   CYTOKINE

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

(2015) Setareh Alampour-Rajabi et al.   FASEB JOURNAL

Potential cell-specific functions of CXCR4 in atherosclerosis

(2015) C. Weber et al.   Hamostaseologie

Macrophage migration inhibitory factor promotes eosinophil accumulation and tissue remodeling in eosinophilic esophagitis

(2015) H S de Souza et al.   Mucosal Immunology

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury

(2014) T. Rassaf et al.   CARDIOVASCULAR RESEARCH

Macrophage Migration Inhibitory Factor Limits Activation-Induced Apoptosis of Platelets via CXCR7-Dependent Akt Signaling

(2014) Madhumita Chatterjee et al.   CIRCULATION RESEARCH

Macrophage Migration Inhibitory Factor Triggers Chemotaxis of CD74+CXCR2+NKT Cells in Chemically Induced IFN-γ–Mediated Skin Inflammation

(2014) Chia-Yuan Hsieh et al.   JOURNAL OF IMMUNOLOGY

MIF Promotes B Cell Chemotaxis through the Receptors CXCR4 and CD74 and ZAP-70 Signaling

(2014) C. Klasen et al.   JOURNAL OF IMMUNOLOGY

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

(2013) Joshua J. Ziarek et al.   ACS Chemical Biology

CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia

(2013) G. Malet-Engra et al.   CANCER RESEARCH

Druggable protein–protein interactions – from hot spots to hot segments

(2013) Nir London et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Human β-defensin-3 structure motifs that are important in CXCR4 antagonism

(2013) Zhimin Feng et al.   FEBS Journal

The role of macrophage migration inhibitory factor in autoimmune liver disease

(2013) David N. Assis et al.   HEPATOLOGY

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

(2013) C. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Arrest Functions of the MIF Ligand/Receptor Axes in Atherogenesis

(2013) Sabine Tillmann et al.   Frontiers in Immunology

Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis

(2012) Isabella Kanzler et al.   BASIC RESEARCH IN CARDIOLOGY

Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction

(2011) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells

(2010) Anne-Frédérique Dessein et al.   CANCER RESEARCH

Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74

(2010) Hongqi Lue et al.   CELLULAR SIGNALLING

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

(2010) Sandra Kraemer et al.   FASEB JOURNAL

Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action

(2010) Hajer Ouertatani-Sakouhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment

(2010) David Simons et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

A functional heteromeric MIF receptor formed by CD74 and CXCR4

(2009) Verena Schwartz et al.   FEBS LETTERS

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

(2009) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family

(2009) James W. Murphy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sequential Tyrosine Sulfation of CXCR4 by Tyrosylprotein Sulfotransferases†

(2008) Christoph Seibert et al.   BIOCHEMISTRY

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE

FireDock: a web server for fast interaction refinement in molecular docking

(2008) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

(2008) C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

(2007) Lee Whitmore et al.   BIOPOLYMERS

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

(2007) Alma Zernecke et al.   CIRCULATION RESEARCH