Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

(2017) Takahiro Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High mobility group box 1 orchestrates tissue regeneration via CXCR4

(2017) Mario Tirone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stem cell research: time for a dose of realism

(2017) Michael Brooks   BMJ-British Medical Journal

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert

(2017) Joseph T. Rodgers et al.   Cell Reports

Stem cell research: time for a dose of realism

(2017) Michael Brooks   BMJ-British Medical Journal

Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting

(2016) Claire C. Maesner et al.   Skeletal Muscle

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response

(2015) J. K. Chan et al.   EMBO Molecular Medicine

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting

(2015) Ling Liu et al.   Nature Protocols

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

(2015) Y. Zhang et al.   SCIENCE

One million haemopoietic stem-cell transplants: a retrospective observational study

(2015) Alois Gratwohl et al.   Lancet Haematology

Comparison between Different Methods for Biomechanical Assessment of Ex Vivo Fracture Callus Stiffness in Small Animal Bone Healing Studies

(2015) Malte Steiner et al.   PLoS One

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Modulating the stem cell niche for tissue regeneration

(2014) Steven W Lane et al.   NATURE BIOTECHNOLOGY

Rethinking clinical delivery of adult stem cell therapies

(2014) Nuala Trainor et al.   NATURE BIOTECHNOLOGY

Preparing the ground for tissue regeneration: from mechanism to therapy

(2014) Stuart J Forbes et al.   NATURE MEDICINE

Translational strategies and challenges in regenerative medicine

(2014) Stefanie Dimmeler et al.   NATURE MEDICINE

Fracture healing: mechanisms and interventions

(2014) Thomas A. Einhorn et al.   Nature Reviews Rheumatology

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

(2013) H. Yanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micro-computed tomography assessment of the progression of fracture healing in mice

(2012) Kevin R. O'Neill et al.   BONE

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Establishment of a femoral critical-size bone defect model in immunodeficient mice

(2012) Stefan Zwingenberger et al.   JOURNAL OF SURGICAL RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

A comparison between micro-CT and histology for the evaluation of cortical bone: effect of polymethylmethacrylate embedding on structural parameters

(2011) F. PARTICELLI et al.   JOURNAL OF MICROSCOPY

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Risk of mortality in patients with cancer who experience febrile neutropenia

(2010) Gary H. Lyman et al.   CANCER

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obtaining of CD34+ cells from healthy blood donors: development of a rapid and efficient procedure using leukoreduction filters

(2010) Yann Peytour et al.   TRANSFUSION

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model

(2008) Lorraine E. Harry et al.   JOURNAL OF ORTHOPAEDIC RESEARCH