Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity

(2020) Lindsay M. Webb et al.   JOURNAL OF CLINICAL INVESTIGATION

Berardinelli-Seip Congenital Lipodystrophy 2/SEIPIN Determines Brown Adipose Tissue Maintenance and Thermogenic Programing

(2020) Hongyi Zhou et al.   Molecular Metabolism

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

(2019) Daniele Musiani et al.   Science Signaling

Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme

(2019) Hanna Witwicka et al.   MOLECULAR AND CELLULAR BIOLOGY

Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue

(2019) Shweta S. Dipali et al.   Reproductive Biology and Endocrinology

Cold-induced lipid dynamics and transcriptional programs in white adipose tissue

(2019) Ziye Xu et al.   BMC BIOLOGY

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

(2019) Aliaksandra Radzisheuskaya et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

(2018) Irem Bayindir‐Buchhalter et al.   EMBO Molecular Medicine

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

(2018) George D. Mcilroy et al.   Molecular Metabolism

Sex differences in lipid and lipoprotein metabolism

(2018) Brian T. Palmisano et al.   Molecular Metabolism

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML

(2017) S Kaushik et al.   LEUKEMIA

Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth

(2016) L. Liu et al.   CANCER RESEARCH

Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice

(2016) Tizhong Shan et al.   DIABETOLOGIA

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

(2016) Vanessa Pellegrinelli et al.   DIABETOLOGIA

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia

(2016) Yanli Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase

(2016) Scott E. LeBlanc et al.   NUCLEIC ACIDS RESEARCH

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

(2016) X Deng et al.   ONCOGENE

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy

(2014) L. Liu et al.   DIABETES

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

Altered Lipid Metabolism in Residual White Adipose Tissues of Bscl2 Deficient Mice

(2013) Weiqin Chen et al.   PLoS One

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function

(2013) A. R. Thiam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seipin: from human disease to molecular mechanism

(2012) Bethany R. Cartwright et al.   JOURNAL OF LIPID RESEARCH

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) and Its Target Genes during Adipogenesis

(2012) Scott E. LeBlanc et al.   MOLECULAR ENDOCRINOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

(2011) Pernille Keller et al.   BMC Endocrine Disorders

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Identification of Genes and Networks Driving Cardiovascular and Metabolic Phenotypes in a Mouse F2 Intercross

(2010) Jonathan M. J. Derry et al.   PLoS One

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

Lipid droplets at a glance

(2009) Y. Guo et al.   JOURNAL OF CELL SCIENCE

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY