Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience

Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo

(2020) Jianglai Wu et al.   NATURE METHODS

SYNPLA, a method to identify synapses displaying plasticity after learning

(2020) Kim Dore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory engrams: Recalling the past and imagining the future

(2020) Sheena A. Josselyn et al.   SCIENCE

Visualization of a Distributed Synaptic Memory Code in the Drosophila Brain

(2020) Florian Bilz et al.   NEURON

Freeze-frame imaging of synaptic activity using SynTagMA

(2020) Alberto Perez-Alvarez et al.   Nature Communications

Comparative Evaluation of Genetically Encoded Voltage Indicators

(2019) Yuki Bando et al.   Cell Reports

High-throughput synapse-resolving two-photon fluorescence microendoscopy for deep-brain volumetric imaging in vivo

(2019) Guanghan Meng et al.   eLife

Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ

(2019) Thomas P. Jensen et al.   Nature Communications

Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity

(2019) Chiayu Q. Chiu et al.   NATURE REVIEWS NEUROSCIENCE

Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics

(2019) Masatoshi Inoue et al.   CELL

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

(2019) Hod Dana et al.   NATURE METHODS

A genetically encoded fluorescent sensor for in vivo imaging of GABA

(2019) Jonathan S. Marvin et al.   NATURE METHODS

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering

(2019) Yudong Gao et al.   NEURON

Cortical layer–specific critical dynamics triggering perception

(2019) James H. Marshel et al.   SCIENCE

Orchestrated ensemble activities constitute a hippocampal memory engram

(2019) Khaled Ghandour et al.   Nature Communications

Local translation in neuronal processes

(2019) Anne Biever et al.   CURRENT OPINION IN NEUROBIOLOGY

Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications

(2019) Anna V. Leopold et al.   Frontiers in Cellular Neuroscience

Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation

(2019) Leila Haery et al.   Frontiers in Neuroanatomy

Optogenetically controlled protein kinases for regulation of cellular signaling

(2018) Anna V. Leopold et al.   CHEMICAL SOCIETY REVIEWS

Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties

(2018) Berquin D. Feese et al.   JOURNAL OF NEUROPHYSIOLOGY

Autophagy Enhances Memory Erasure through Synaptic Destabilization

(2018) Mohammad Shehata et al.   JOURNAL OF NEUROSCIENCE

Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

(2018) John Lisman et al.   NATURE NEUROSCIENCE

Behavioral, cellular, and synaptic tagging frameworks

(2018) Masanori Nomoto et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Long-term potentiation in the hippocampus: discovery, mechanisms and function

(2018) Tim V.P. Bliss et al.   Neuroforum

Clustered plasticity in Long-Term Potentiation: How strong synapses persist to maintain long-term memory

(2018) Marina Mikhaylova et al.   Neuroforum

A Dedicated Population for Reward Coding in the Hippocampus

(2018) Jeffrey L. Gauthier et al.   NEURON

Interregional synaptic maps among engram cells underlie memory formation

(2018) Jun-Hyeok Choi et al.   SCIENCE

Synapse-specific representation of the identity of overlapping memory engrams

(2018) Kareem Abdou et al.   SCIENCE

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

(2018) Sami El-Boustani et al.   SCIENCE

Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

(2018) Francisco T. Gallo et al.   Frontiers in Behavioral Neuroscience

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

(2018) Thomas Pfeiffer et al.   eLife

Image-Based Profiling of Synaptic Connectivity in Primary Neuronal Cell Culture

(2018) Peter Verstraelen et al.   Frontiers in Neuroscience

Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning

(2018) Wataru Kakegawa et al.   NEURON

Silent Synapse Unsilencing in Hippocampal CA1 Neurons for Associative Fear Memory Storage

(2018) Yao Wang et al.   CEREBRAL CORTEX

Silent Learning

(2018) Janine I. Rossato et al.   CURRENT BIOLOGY

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

(2018) Jonathan S. Marvin et al.   NATURE METHODS

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior

(2018) Ee-Lynn Yap et al.   NEURON

Improved methods for marking active neuron populations

(2018) Benjamien Moeyaert et al.   Nature Communications

The fate of hippocampal synapses depends on the sequence of plasticity-inducing events

(2018) J Simon Wiegert et al.   eLife

Bridging Synaptic and Epigenetic Maintenance Mechanisms of the Engram

(2018) Madeleine Kyrke-Smith et al.   Frontiers in Molecular Neuroscience

Heroes of the Engram

(2017) Sheena A. Josselyn et al.   JOURNAL OF NEUROSCIENCE

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons

(2017) Wenjing Wang et al.   NATURE BIOTECHNOLOGY

Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

(2017) Weijian Zong et al.   NATURE METHODS

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor

(2017) Hideji Murakoshi et al.   NEURON

Silencing Neurons: Tools, Applications, and Experimental Constraints

(2017) J. Simon Wiegert et al.   NEURON

Optogenetic Control of Synaptic Composition and Function

(2017) Brooke L. Sinnen et al.   NEURON

The dialectic of Hebb and homeostasis

(2017) Gina G. Turrigiano   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hippocampal GABAergic Inhibitory Interneurons

(2017) Kenneth A. Pelkey et al.   PHYSIOLOGICAL REVIEWS

Advances in Two-Photon Scanning and Scanless Microscopy Technologies for Functional Neural Circuit Imaging

(2017) Simon R. Schultz et al.   PROCEEDINGS OF THE IEEE

Inhibitory engrams in perception and memory

(2017) Helen C. Barron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

(2017) Sebastian Sulis Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engrams and circuits crucial for systems consolidation of a memory

(2017) Takashi Kitamura et al.   SCIENCE

Synaptic Ensemble Underlying the Selection and Consolidation of Neuronal Circuits during Learning

(2017) Yoshio Hoshiba et al.   Frontiers in Neural Circuits

Activity-dependent expression of Channelrhodopsin at neuronal synapses

(2017) Francesco Gobbo et al.   Nature Communications

Is Arc mRNA Unique: A Search for mRNAs That Localize to the Distal Dendrites of Dentate Gyrus Granule Cells Following Neural Activity

(2017) Christopher A. de Solis et al.   Frontiers in Molecular Neuroscience

Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

(2016) Lucas Sjulson et al.   Annual Review of Genetics

Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking

(2016) Bruce E. Herring et al.   Annual Review of Physiology

What is memory? The present state of the engram

(2016) Mu-ming Poo et al.   BMC BIOLOGY

Subcellular Imaging of Voltage and Calcium Signals Reveals Neural Processing In Vivo

(2016) Helen H. Yang et al.   CELL

Overexpression of Protein Kinase M  in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats

(2016) S. R. M. Schuette et al.   JOURNAL OF NEUROSCIENCE

Still searching for the engram

(2016) Howard Eichenbaum   LEARNING & BEHAVIOR

Locus coeruleus and dopaminergic consolidation of everyday memory

(2016) Tomonori Takeuchi et al.   NATURE

Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum

(2016) Daniela B Pereira et al.   NATURE NEUROSCIENCE

Genetically encoded indicators of neuronal activity

(2016) Michael Z Lin et al.   NATURE NEUROSCIENCE

Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo

(2016) Katherine L. Villa et al.   NEURON

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites

(2016) Youn Na et al.   NEURON

Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development

(2016) Hai-Yan He et al.   NEURON

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

(2016) Robin Tremblay et al.   NEURON

The Diversity of Cortical Inhibitory Synapses

(2016) Yoshiyuki Kubota et al.   Frontiers in Neural Circuits

A family of photoswitchable NMDA receptors

(2016) Shai Berlin et al.   eLife

Sensitive red protein calcium indicators for imaging neural activity

(2016) Hod Dana et al.   eLife

Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex

(2016) Onur Gökçe et al.   eLife

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Memory engram storage and retrieval

(2015) Susumu Tonegawa et al.   CURRENT OPINION IN NEUROBIOLOGY

Is the place cell a “supple” engram?

(2015) Aryeh Routtenberg   HIPPOCAMPUS

Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome

(2015) M. F. Ifrim et al.   JOURNAL OF NEUROSCIENCE

Impermanence of dendritic spines in live adult CA1 hippocampus

(2015) Alessio Attardo et al.   NATURE

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

High-performance probes for light and electron microscopy

(2015) Sarada Viswanathan et al.   NATURE METHODS

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo

(2015) Yong Zhang et al.   NATURE NEUROSCIENCE

Finding the engram

(2015) Sheena A. Josselyn et al.   NATURE REVIEWS NEUROSCIENCE

Rapid Dispersion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement during LTP

(2015) Yoichi Araki et al.   NEURON

Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time

(2015) Fiona E. Müllner et al.   NEURON

Spontaneous Activity Drives Local Synaptic Plasticity In Vivo

(2015) Johan Winnubst et al.   NEURON

Memory Engram Cells Have Come of Age

(2015) Susumu Tonegawa et al.   NEURON

Synaptic clustering within dendrites: An emerging theory of memory formation

(2015) George Kastellakis et al.   PROGRESS IN NEUROBIOLOGY

Engram cells retain memory under retrograde amnesia

(2015) T. J. Ryan et al.   SCIENCE

Memory Consolidation

(2015) Larry R. Squire et al.   Cold Spring Harbor Perspectives in Biology

Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation

(2015) Lindsey J. Macpherson et al.   Nature Communications

Optical Dissection of Experience-Dependent Pre- and Postsynaptic Plasticity in the Drosophila Brain

(2015) Ulrike Pech et al.   Cell Reports

Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory

(2015) Noriaki Ohkawa et al.   Cell Reports

pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis

(2014) Yi Shen et al.   JOURNAL OF CELL BIOLOGY

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Synaptic tagging during memory allocation

(2014) Thomas Rogerson et al.   NATURE REVIEWS NEUROSCIENCE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Balance and Stability of Synaptic Structures during Synaptic Plasticity

(2014) Daniel Meyer et al.   NEURON

Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications

(2014) A. Dawydow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating excitation through plasticity at inhibitory synapses

(2014) Vivien Chevaleyre et al.   Frontiers in Cellular Neuroscience

Actin-dependent mechanisms in AMPA receptor trafficking

(2014) Jonathan G. Hanley   Frontiers in Cellular Neuroscience

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

(2014) Thomas E. Chater et al.   Frontiers in Cellular Neuroscience

Shaping inhibition: activity dependent structural plasticity of GABAergic synapses

(2014) Carmen E. Flores et al.   Frontiers in Cellular Neuroscience

A new era for functional labeling of neurons: activity-dependent promoters have come of age

(2014) Takashi Kawashima et al.   Frontiers in Neural Circuits

Meet the players: local translation at the synapse

(2014) Sandra M. Fernandez-Moya et al.   Frontiers in Molecular Neuroscience

Function of Dendritic Spines on Hippocampal Inhibitory Neurons

(2013) V. Scheuss et al.   CEREBRAL CORTEX

Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation

(2013) J. S. Grimley et al.   JOURNAL OF NEUROSCIENCE

Monitoring synaptic and neuronal activity in 3D with synthetic and genetic indicators using a compact acousto-optic lens two-photon microscope

(2013) Tomás Fernández-Alfonso et al.   JOURNAL OF NEUROSCIENCE METHODS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

Functional labeling of neurons and their projections using the synthetic activity–dependent promoter E-SARE

(2013) Takashi Kawashima et al.   NATURE METHODS

Probabilistic brains: knowns and unknowns

(2013) Alexandre Pouget et al.   NATURE NEUROSCIENCE

Memory recall and modifications by activating neurons with elevated CREB

(2013) Jieun Kim et al.   NATURE NEUROSCIENCE

Visualizing presynaptic function

(2013) Ege T Kavalali et al.   NATURE NEUROSCIENCE

Memorable Trends

(2013) Yadin Dudai et al.   NEURON

Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression

(2013) Vikram Jakkamsetti et al.   NEURON

Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI)

(2013) John Y. Lin et al.   NEURON

Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations

(2013) Casey J. Guenthner et al.   NEURON

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The search for a hippocampal engram

(2013) M. Mayford   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Creating a False Memory in the Hippocampus

(2013) S. Ramirez et al.   SCIENCE

Holographic optogenetic stimulation of patterned neuronal activity for vision restoration

(2013) Inna Reutsky-Gefen et al.   Nature Communications

Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ

(2012) Hiroyuki Okuno et al.   CELL

Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation

(2012) Joseph L. Dynes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nonlinear dendritic integration of sensory and motor input during an active sensing task

(2012) Ning-long Xu et al.   NATURE

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

(2012) Margaret T Butko et al.   NATURE NEUROSCIENCE

Mechanisms of CaMKII action in long-term potentiation

(2012) John Lisman et al.   NATURE REVIEWS NEUROSCIENCE

Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex

(2012) Jerry L. Chen et al.   NEURON

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Locally Synchronized Synaptic Inputs

(2012) N. Takahashi et al.   SCIENCE

Generation of a Synthetic Memory Trace

(2012) A. R. Garner et al.   SCIENCE

Synapses and Memory Storage

(2012) M. Mayford et al.   Cold Spring Harbor Perspectives in Biology

Calcium Signaling in Dendritic Spines

(2012) M. J. Higley et al.   Cold Spring Harbor Perspectives in Biology

Visualization of Subunit-Specific Delivery of Glutamate Receptors to Postsynaptic Membrane during Hippocampal Long-Term Potentiation

(2012) Hiromitsu Tanaka et al.   Cell Reports

Catching the engram: strategies to examine the memory trace

(2012) Masanori Sakaguchi et al.   Molecular Brain

Synaptic clustering during development and learning: the why, when, and how

(2012) Johan Winnubst et al.   Frontiers in Molecular Neuroscience

Overexpression of PKMζ Alters Morphology and Function of Dendritic Spines in Cultured Cortical Neurons

(2011) Shiri Ron et al.   CEREBRAL CORTEX

Long-term plasticity at inhibitory synapses

(2011) Pablo E Castillo et al.   CURRENT OPINION IN NEUROBIOLOGY

Functional mapping of single spines in cortical neurons in vivo

(2011) Xiaowei Chen et al.   NATURE

mGRASP enables mapping mammalian synaptic connectivity with light microscopy

(2011) Jinhyun Kim et al.   NATURE METHODS

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

Loss of Sensory Input Causes Rapid Structural Changes of Inhibitory Neurons in Adult Mouse Visual Cortex

(2011) Tara Keck et al.   NEURON

Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites

(2011) Thomas Kleindienst et al.   NEURON

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

(2011) Hiroshi Makino et al.   NEURON

Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

(2011) Z. Varga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Calcium Control of Neurotransmitter Release

(2011) T. C. Sudhof   Cold Spring Harbor Perspectives in Biology

Imaging synaptic plasticity

(2011) Zahid Padamsey et al.   Molecular Brain

The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses

(2011) Arianna Maffei   NEURAL PLASTICITY

Imaging Inhibitory Synaptic Potentials Using Voltage Sensitive Dyes

(2010) Marco Canepari et al.   BIOPHYSICAL JOURNAL

LTP- and LTD-inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo

(2010) Eser Yilmaz-Rastoder et al.   HIPPOCAMPUS

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory

(2010) S.-H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Rapid formation and selective stabilization of synapses for enduring motor memories

(2009) Tonghui Xu et al.   NATURE

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

A genetically encoded reporter of synaptic activity in vivo

(2009) Elena Dreosti et al.   NATURE METHODS

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Selective Erasure of a Fear Memory

(2009) J.-H. Han et al.   SCIENCE

The Arc of synaptic memory

(2009) Clive R. Bramham et al.   EXPERIMENTAL BRAIN RESEARCH

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

GABAergic synapses are formed without the involvement of dendritic protrusions

(2008) Corette J Wierenga et al.   NATURE NEUROSCIENCE

Metaplasticity: tuning synapses and networks for plasticity

(2008) Wickliffe C. Abraham   NATURE REVIEWS NEUROSCIENCE

Characterization and Subcellular Targeting of GCaMP-Type Genetically-Encoded Calcium Indicators

(2008) Tianyi Mao et al.   PLoS One

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning

(2008) N. Matsuo et al.   SCIENCE