Review
Neurosciences
Luca Pancotti, Lisa Topolnik
Summary: This article reviews the evidence regarding the modulatory effects of acetylcholine (ACh) on dendritic computations in three subtypes of hippocampal interneurons: fast-spiking parvalbumin-positive (PV+) cells, somatostatin-expressing (SOM+) oriens lacunosum moleculare cells, and vasoactive intestinal polypeptide-expressing (VIP+) interneuron-selective interneurons. The distribution and actions of cholinergic receptors on these interneurons are discussed, along with the potential modulation of dendritic Ca2+ signaling and neuronal activity. The article suggests that cholinergic modulation can shape dendritic integration and plasticity in interneurons in a cell type-specific manner, which is important for understanding their contribution to large-scale network activity.
Article
Neurosciences
Maithe Loisy, Guillaume Bouisset, Sebastien Lopez, Maud Muller, Alena Spitsyn, Jeanne Duval, Rebecca Ann Piskorowski, Laure Verret, Vivien Chevaleyre
Summary: This study reveals a novel inhibitory plasticity mediated by cannabinoid type 1 receptor activation (CB1R-iLTD) in the CA2 region of the hippocampus, which plays a crucial role in social memory formation. The study also demonstrates that the previous induction of Delta-opioid receptor-mediated long-term depression (DOR-iLTDs) is necessary for the CB1R-iLTD to occur. The findings provide insights into the interplay between inhibitory plasticities and a new mechanism for social memory formation.
Review
Biochemistry & Molecular Biology
Ewa Baczynska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Wlodarczyk, Blazej Ruszczycki
Summary: This article reviews experimental approaches designed to assess quantitative features of dendritic spines under physiological stimuli and in pathological conditions. By comparing various methodological pipelines and systematically summarizing the methodology and results of relevant experiments, the focus is on quantitative data regarding the number of animals, cells, dendritic spines, types of studied parameters, size of observed changes, and their statistical significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Grzegorz Wiera, Patrycja Brzdak, Anna Maria Lech, Katarzyna Lebida, Jadwiga Jablonska, Przemyslaw Gmerek, Jerzy W. Mozrzymas
Summary: This study provides the first evidence that integrins play a key role in regulating the endogenous modulatory mechanisms of GABAergic inhibition and plasticity in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xuan Li, Hexige Saiyin, Jian-hua Zhou, Qiong Yu, Wei-min Liang
Summary: Ketamine exposure inhibits HDAC6 expression in MSNs, leading to increased stability of microtubules and delayed dendritic growth, but the effects are reversible. This study unveils a novel role of HDAC6 in regulating ketamine-induced deficits in MSNs development, offering innovative implications for ketamine clinical applications.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Neurosciences
Ting Feng, Christian Alicea, Vincent Pham, Amanda Kirk, Simon Pieraut
Summary: The study found that using an enriched environment during the preweaning period affects the circuit plasticity of inhibitory cell types in the hippocampus, with CCK+ basket cells showing a significant increase in somatic inhibition and PV+ cells showing no changes. The change in somatic inhibition from CCK+ neurons increases CB1R-mediated inhibition in the circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Chiaki Hoshino, Ayumu Konno, Nobutake Hosoi, Ryosuke Kaneko, Ryo Mukai, Junichi Nakai, Hirokazu Hirai
Summary: The newly developed mGAD65 promoter shows high specificity and efficiency for transducing GABAergic interneurons in a manner almost identical to or slightly higher than the mDlx enhancer. It preferentially transduces PV-expressing interneurons and chandelier cells, demonstrating its potential for AAV-mediated targeting and manipulation of GABAergic neurons in the central nervous system. This promoter also enables the expression of functional molecules for monitoring neuronal activity, making it a useful tool for studying neuropsychiatric disorders.
Article
Neurosciences
Jan A. Knobloch, Gilles Laurent, Marcel A. Lauterbach
Summary: This study used superresolution STED microscopy to explore the shape and distribution characteristics of dendritic spines in the turtle cortex. The results showed that dendritic spines can be classified into several distinguishable shape categories, and spines of a given category are not randomly distributed, but rather appear more frequently on certain dendrites. Additionally, significant inter-dendrite differences in parameters such as spine density and length were observed.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Guang-ying Li, Qiu-zi Wu, Tian-jia Song, Xue-chu Zhen, Xiang Yu
Summary: Normal brain function relies on the complex neural network, which is formed and maintained through synaptogenesis and synaptic plasticity. Deficiency in growth hormone can lead to brain development abnormalities and impair learning and memory, while growth hormone replacement therapy has been shown to ameliorate cognitive deficits. However, the underlying mechanism is still largely unknown.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Summary: The inactivation of Presenilin gene in inhibitory neurons in the hippocampus leads to decreased GABAergic responses and enhanced synaptic plasticity, indicating the important role of Presenilin in calcium homeostasis and synaptic transmission.
Article
Biochemistry & Molecular Biology
Amanda Schneeweis, Daniel T. S. Pak
Summary: Tau protein has been found to localize in various subcellular domains of neurons and has multiple physiological functions. However, the lack of comprehensive phosphosite analysis obscures our understanding of these functions. Therefore, establishing a comprehensive map of tau phosphorylation signatures can clarify its diverse physiological functions in different locations and guide the development of novel therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Behavioral Sciences
Kirstie A. Cummings, Anthony F. Lacagnina, Roger L. Clem
Summary: Recent studies suggest that while excitatory projection neurons (PNs) play a critical role in memory functions, their activity during learning and recall is extensively regulated by a diverse array of GABAergic interneurons (INs). These findings highlight the importance of investigating the role of interneurons in fear memory networks.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Minhan Ka, Hyung-Goo Kim, Woo-Yang Kim
Summary: This study reveals the important role of WDR5 in neuronal development, specifically in neuronal placement and dendrite polarization in the cerebral cortex. WDR5 deficiency leads to defects in neuronal migration and dendrite polarity, accompanied by changes in gene expression and histone modification. These findings provide new mechanistic insights into the neuropathology associated with histone methyltransferase dysfunction.
MOLECULAR NEUROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
David Colameo, Gerhard Schratt
Summary: This article investigates the plasticity mechanisms of neurons in the face of network activity disruptions. The study reveals that individual synapses are tagged for future strengthening during periods of chronic inactivity. These findings support the role of local mechanisms in homeostatic synaptic plasticity.
Review
Neurosciences
Gary Jean, Joseph Carton, Kaleem Haq, Alberto E. Musto
Summary: Epilepsy is a chronic CNS disease with no known disease-modifying therapy. The generation of aberrant neuronal networks is considered a leading mechanism of epileptogenesis. Changes in dendritic spine morphology, associated with altered expression of various proteins and molecules, may contribute to the hyperexcitability and abnormal synaptic connections seen in epilepsy. Targeting dendritic spine machinery could potentially limit or reverse the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biology
Mu-ming Poo, Michele Pignatelli, Tomas J. Ryan, Susumu Tonegawa, Tobias Bonhoeffer, Kelsey C. Martin, Andrii Rudenko, Li-Huei Tsai, Richard W. Tsien, Gord Fishell, Caitlin Mullins, J. Tiago Goncalves, Matthew Shtrahman, Stephen T. Johnston, Fred H. Gage, Yang Dan, John Long, Gyorgy Buzsaki, Charles Stevens
Article
Biochemistry & Molecular Biology
Sabine Liebscher, Georg B. Keller, Pieter M. Goltstein, Tobias Bonhoeffer, Mark Huebener
Article
Multidisciplinary Sciences
Tobias Rose, Juliane Jaepel, Mark Huebener, Tobias Bonhoeffer
Article
Neurosciences
Juliane Jaepel, Mark Hubener, Tobias Bonhoeffer, Tobias Rose
NATURE NEUROSCIENCE
(2017)
Article
Biochemical Research Methods
Simon Weiler, Joel Bauer, Mark Huebener, Tobias Bonhoeffer, Tobias Rose, Volker Scheuss
Article
Neurosciences
Volker Scheuss
FRONTIERS IN NEURAL CIRCUITS
(2018)
Article
Multidisciplinary Sciences
Karl E. Bauer, Inmaculada Segura, Imre Gaspar, Volker Scheuss, Christin IIlig, Georg Ammer, Saskia Hutten, Eugenia Basyuk, Sandra M. Fernandez-Moya, Janina Ehses, Edouard Bertrand, Michael A. Kiebler
NATURE COMMUNICATIONS
(2019)
Article
Neurosciences
Alessandro La Chioma, Tobias Bonhoeffer, Mark Huebener
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Sandra Reinert, Mark Huebener, Tobias Bonhoeffer, Pieter M. Goltstein
Summary: The ability to categorize sensory stimuli is crucial for an animal's survival in a complex environment, with the prefrontal cortex playing a prominent role in the formation and representation of category-selective neurons.
Article
Neurosciences
Pieter M. Goltstein, Sandra Reinert, Tobias Bonhoeffer, Mark Huebener
Summary: The study by Goltstein et al. investigates the role of mouse visual cortical areas in information-integration category learning, finding widespread changes in neuronal response properties, particularly in the postrhinal cortex. The results suggest that associative memories form a brain-wide distributed network, with learning in early stages shaping perceptual representations and supporting semantic content downstream.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Joel Bauer, Simon Weiler, Martin H. P. Fernholz, David Laubender, Volker Scheuss, Mark Huebener, Tobias Bonhoeffer, Tobias Rose
Summary: Recent studies have shown that functional eye-specific input selection and refinement in dLGN limit convergent interactions, favoring monocularity.
Article
Biochemistry & Molecular Biology
Simon Weiler, Drago Guggiana Nilo, Tobias Bonhoeffer, Mark Huebener, Tobias Rose, Volker Scheuss
Summary: In this study, the researchers found direct correlations between the dendritic morphology and functional input connectivity, as well as the orientation and direction tuning of L2/3 PCs. The elongation of the apical dendritic tree along the postsynaptic preferred orientation played an important role in the representation of visual space and the orientation tuning. Additionally, sharply orientation-tuned cells had a less complex apical tree compared to broadly tuned cells. The spatial distribution of presynaptic partners in direction-selective L2/3 PCs was offset from the soma opposite to the preferred direction, and the excitatory input distribution was spatially skewed along the preferred direction, in contrast to the inhibitory distribution.
Article
Neurosciences
Simon Weiler, Drago Guggiana Nilo, Tobias Bonhoeffer, Mark Hubener, Tobias Rose, Volker Scheuss
Summary: This study investigates the variations in the properties of neural cells in the visual cortex of mice at different depths. The results indicate that the structural and functional characteristics of these cells change with depth, with deeper cells showing stronger responses to visual stimuli and being more driven by contralateral eye stimulation. However, these changes are gradual and there are no discrete subtypes.