Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer’s Diseases

Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β

(2020) Nanjaiah Lalitha et al.   Journal of Functional Foods

Mulberry Fruit Extract Alleviates Cognitive Impairment by Promoting the Clearance of Amyloid-β and Inhibiting Neuroinflammation in Alzheimer’s Disease Mice

(2020) Dianxun Liu et al.   NEUROCHEMICAL RESEARCH

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's disease

(2019) Richard Barnett   LANCET

Silymarin’s Inhibition and Treatment Effects for Alzheimer’s Disease

(2019) Hong Guo et al.   MOLECULES

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

(2019) Dan Liu et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Management of oxidative stress and other pathologies in Alzheimer’s disease

(2019) Miriama Simunkova et al.   ARCHIVES OF TOXICOLOGY

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway

(2019) Nianshui Jing et al.   Open Medicine

Herpes Simplex Virus, Alzheimer’s Disease and a Possible Role for Rab GTPases

(2019) Elaine L. Bearer et al.   Frontiers in Cell and Developmental Biology

Inhibitory Effect of a Flavonoid Dihydromyricetin against Aβ40 Amyloidogenesis and Its Associated Cytotoxicity

(2019) Longgang Jia et al.   ACS Chemical Neuroscience

Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

(2019) S. Sarkar et al.   BRAIN RESEARCH

A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3′,4′-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study

(2019) Klaudia Jomová et al.   MOLECULES

GIP has neuroprotective effects in Alzheimer and Parkinson’s disease models

(2019) Zhen Qiang Zhang et al.   PEPTIDES

Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimerʼs Disease

(2019) Mehjabeen Naushad et al.   PLANTA MEDICA

Persistent Infection with Herpes Simplex Virus 1 and Alzheimer’s Disease—A Call to Study How Variability in Both Virus and Host may Impact Disease

(2019) Colleen A. Mangold et al.   Viruses-Basel

Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases

(2019) Hilda Martínez-Coria et al.   Frontiers in Pharmacology

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice

(2018) Jie Feng et al.   CNS Neuroscience & Therapeutics

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

(2018) Douglas G. Peters et al.   Metallomics

The role of phenolic OH groups of flavonoid compounds with H-bond formation ability to suppress amyloid mature fibrils by destabilizing β-sheet conformation of monomeric Aβ17-42

(2018) Sahar Andarzi Gargari et al.   PLoS One

In Silico Investigation of the Pharmacological Mechanisms of Beneficial Effects of Ginkgo biloba L. on Alzheimer’s Disease

(2018) Hongxiang Li et al.   Nutrients

The Metal Theory of Alzheimer's Disease

(2018) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks

(2018) Benjamin M. Bader et al.   Frontiers in Pharmacology

Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway

(2018) Ping Sun et al.   BIOSCIENCE REPORTS

Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination

(2018) Hanwen Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-κB signalling in human melanoma cells

(2017) Ding-Zhou Zhou et al.   FREE RADICAL RESEARCH

Kinetic Insights into Zn2+-Induced Amyloid β-Protein Aggregation Revealed by Stopped-Flow Fluorescence Spectroscopy

(2017) Jingjing Guo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury

(2017) Ping Qiu et al.   TOXICOLOGY LETTERS

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Fe2+binding on amyloid β-peptide promotes aggregation

(2016) Subramaniam Boopathi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Myricetin: A Dietary Molecule with Diverse Biological Activities

(2016) Deepak Semwal et al.   Nutrients

Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

(2016) Xianjuan Kou et al.   Oncotarget

Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents

(2015) Sina Shadfar et al.   ARCHIVES OF PHARMACAL RESEARCH

Phytochemical Characterization of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) of 17 Cultivars and Their Antioxidant Properties

(2015) Xianan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Folding and Mechanisms of Proteostasis

(2015) José Díaz-Villanueva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases

(2015) Daniel Grenier et al.   PLoS One

Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways

(2014) Juan Xia et al.   FOOD AND CHEMICAL TOXICOLOGY

Insulin resistance in Alzheimer's disease

(2014) Kelly T. Dineley et al.   NEUROBIOLOGY OF DISEASE

Dihydromyricetin Ameliorates Behavioral Deficits and Reverses Neuropathology of Transgenic Mouse Models of Alzheimer’s Disease

(2014) Jing Liang et al.   NEUROCHEMICAL RESEARCH

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Characterization of Early Stage Intermediates in the Nucleation Phase of Aβ Aggregation

(2012) Jiali Zhai et al.   BIOCHEMISTRY

Effect of Maturity on Phenolics (Phenolic Acids and Flavonoids) Profile of Strawberry Cultivars and Mulberry Species from Pakistan

(2012) Tahir Mahmood et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

(2012) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis

(2011) Nam Joo Kang et al.   Annals of the New York Academy of Sciences

Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

(2011) Alaina S. DeToma et al.   CHEMBIOCHEM

Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro

(2011) Di Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1–myricetin a case study

(2011) Sandipan Chakraborty et al.   NEUROCHEMISTRY INTERNATIONAL

Modulation of endogenous antioxidant system by wine polyphenols in human disease

(2010) Ramón Rodrigo et al.   CLINICA CHIMICA ACTA

Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways

(2010) Kyoung Ah Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action

(2009) Zhi Hong Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

(2009) Cindy M Sondag et al.   Journal of Neuroinflammation

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

(2009) Bo Su et al.   NEUROSCIENCE LETTERS

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

(2008) Alain Boom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neprilysin and Amyloid Beta Peptide Degradation

(2008) Louis Hersh et al.   Current Alzheimer Research

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases

(2007) Yoshiari Shimmyo et al.   JOURNAL OF NEUROSCIENCE RESEARCH