ATP modulates SLC7A5 (LAT1) synergistically with cholesterol

Effect of Cholesterol on the Organic Cation Transporter OCTN1 (SLC22A4)

(2020) Lorena Pochini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

(2020) Naohiro Okano et al.   INVESTIGATIONAL NEW DRUGS

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

Cholesterol depletion inhibits Na+,K+-ATPase activity in a near-native membrane environment

(2019) Alvaro Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Aspects of the Vacuolar CAT2 Arginine Transporter of S. lycopersicum: Role of Osmotic Pressure and Cations

(2019) Jessica Cosco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

(2019) Yongchan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

(2019) Ekaitz Errasti-Murugarren et al.   Nature Communications

Insights into the transport side of the human SLC38A9 transceptor

(2019) Mariafrancesca Scalise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001

(2019) Joe A. Kaczmarski et al.   BIOCHEMISTRY

Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 (SLC22A2)

(2019) Severin Hörmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

(2019) Natesh Singh et al.   Scientific Reports

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1

(2018) Natesh Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

(2018) Louise Laursen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for amino acid transport by the CAT family of SLC7 transporters

(2018) Katharina E. J. Jungnickel et al.   Nature Communications

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

(2018) Talia Zeppelin et al.   PLoS Computational Biology

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

Uncoupling proteins: Martin Klingenberg's contributions for 40 years

(2018) Karim S. Echtay et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

(2018) Huan-Chieh Chien et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico Description of LAT1 Transport Mechanism at an Atomistic Level

(2018) Luca Palazzolo et al.   Frontiers in Chemistry

Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods

(2018) Natesh Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

(2017) Ryuichi Ohgaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(2017) David Dickens et al.   Scientific Reports

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC

(2016) Hüseyin Ilgü et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

(2015) Samuel Genheden et al.   Expert Opinion on Drug Discovery

LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter

(2015) Lara Napolitano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functional and Molecular Effects of Mercury Compounds on the Human OCTN1 Cation Transporter: C50 and C136 Are the Targets for Potent Inhibition

(2014) Michele Galluccio et al.   TOXICOLOGICAL SCIENCES

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Cloning, Large Scale Over-Expression in E. coli and Purification of the Components of the Human LAT 1 (SLC7A5) Amino Acid Transporter

(2013) Michele Galluccio et al.   PROTEIN JOURNAL

Detecting adenosine triphosphate in the pericellular space

(2013) S. Falzoni et al.   Interface Focus

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

(2013) Jacques Fantini et al.   Frontiers in Physiology

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

(2013) Mariafrancesca Scalise et al.   Pharmaceutics

CD98 at the crossroads of adaptive immunity and cancer

(2012) J. M. Cantor et al.   JOURNAL OF CELL SCIENCE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease

(2011) Lorena Pochini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES