Functional and Molecular Effects of Mercury Compounds on the Human OCTN1 Cation Transporter: C50 and C136 Are the Targets for Potent Inhibition

Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling

(2014) Lorena Pochini et al.   BIOCHEMICAL PHARMACOLOGY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Glutathione controls the redox state of the mitochondrial carnitine/acylcarnitine carrier Cys residues by glutathionylation

(2013) Nicola Giangregorio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury

(2013) José G. Dórea et al.   JOURNAL OF APPLIED TOXICOLOGY

FAD Synthesis and Degradation in the Nucleus Create a Local Flavin Cofactor Pool

(2013) Teresa Anna Giancaspero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoneine, a Novel Selenium-Containing Compound, Mediates Detoxification Mechanisms against Methylmercury Accumulation and Toxicity in Zebrafish Embryo

(2013) Michiaki Yamashita et al.   MARINE BIOTECHNOLOGY

Functional Analysis of Novel Variants in the Organic Cation/Ergothioneine Transporter 1 Identified in Singapore Populations

(2013) Dorothy Su Lin Toh et al.   MOLECULAR PHARMACEUTICS

Crystal structure of a eukaryotic phosphate transporter

(2013) Bjørn P. Pedersen et al.   NATURE

Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics

(2013) Annamaria Tonazzi et al.   PLoS One

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

(2013) Mariafrancesca Scalise et al.   Pharmaceutics

Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: The mouse carnitine transporter OCTN3

(2012) Mariafrancesca Scalise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

(2012) Thomas A. Hopf et al.   CELL

Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system

(2012) Lorena Pochini et al.   LIFE SCIENCES

Strategies of Bacterial Over Expression of Membrane Transporters Relevant in Human Health: The Successful Case of the Three Members of OCTN Subfamily

(2012) Cesare Indiveri et al.   MOLECULAR BIOTECHNOLOGY

Inhibition of the OCTN2 carnitine transporter by HgCl2and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity

(2012) Lorena Pochini et al.   TOXICOLOGY MECHANISMS AND METHODS

Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed inEscherichia coli

(2011) Lorena Pochini et al.   BIOCHEMICAL JOURNAL

The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: Kinetics and inactivation by methylmercury

(2011) Francesca Oppedisano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease

(2011) Lorena Pochini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of heavy metal cations on the mitochondrial ornithine/citrulline transporter reconstituted in liposomes

(2011) Annamaria Tonazzi et al.   BIOMETALS

Acetylcholine as an age-dependent non-neuronal source in the heart

(2010) Obaida R. Rana et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Inactivation by Hg 2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling

(2010) Francesca Oppedisano et al.   BIOCHEMICAL PHARMACOLOGY

Mercury induces inflammatory mediator release from human mast cells

(2010) Duraisamy Kempuraj et al.   Journal of Neuroinflammation

Transport of Inorganic Mercury and Methylmercury in Target Tissues and Organs

(2010) Christy C. Bridges et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

(2010) Yukio Kato et al.   PHARMACEUTICAL RESEARCH

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Over-expression in E. coli and purification of the human OCTN1 transport protein

(2009) Michele Galluccio et al.   PROTEIN EXPRESSION AND PURIFICATION

Functional Characterization of Ergothioneine Transport by Rat Organic Cation/Carnitine Transporter Octn1 (slc22a4)

(2008) Toshimichi Nakamura et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes

(2008) Lorena Pochini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis and characterization of carnitine nitro-derivatives

(2007) Oriana Piermatti et al.   BIOORGANIC & MEDICINAL CHEMISTRY