Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

Targeting apoptotic caspases in cancer

(2020) Ashley Boice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

(2019) Rone Aparecido De Grandis et al.   BIOORGANIC CHEMISTRY

Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase

(2019) Jin-can Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

High in Vitro and in Vivo Tumor-Selective Novel Ruthenium(II) Complexes with 3-(2′-Benzimidazolyl)-7-fluoro-coumarin

(2019) Qi-Pin Qin et al.   ACS Medicinal Chemistry Letters

Chiral ruthenium(II) complex Δ-[Ru(bpy)2(o-FMPIP)] (bpy = bipyridine, o-FMPIP = 2-(2′-trifluoromethyphenyl) imidazo[4,5-f][1,10]phenanthroline) as potential apoptosis inducer via DNA damage

(2019) Mingjun Bai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased ROS generation causes apoptosis-like death: Mechanistic insights into the anti-Leishmania activity of a potent ruthenium(II) complex

(2019) Mônica Soares Costa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mitochondria as playmakers of apoptosis, autophagy and senescence

(2019) Marianna Abate et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Design and synthesis of new ruthenium polypyridyl complexes with potent antitumor activity in vitro

(2019) Guang-Bin Jiang et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Recent advances in ruthenium and platinum based supramolecular coordination complexes for antitumor therapy

(2019) Xiaoming Zhang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Chemistry and reactivity of ruthenium(II) complexes: DNA/protein binding mode and anticancer activity are related to the complex structure

(2019) Ana Rilak Simović et al.   COORDINATION CHEMISTRY REVIEWS

Novel tetranuclear ruthenium(II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo

(2019) Mohamed Kasim Mohamed Subarkhan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and apoptosis in breast and prostate tumor cells

(2019) Israel Higino de Sousa et al.   TOXICOLOGY IN VITRO

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Synthesis and characterization of two new trans palladium (II) complexes containing benzylamine ligand: DNA/BSA interactions, molecular docking and in vitro cytotoxic activity

(2018) Kazem Karami et al.   INORGANICA CHIMICA ACTA

Ru(II)-Thymine Complex Causes Cell Growth Inhibition and Induction of Caspase-Mediated Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

(2018) Maiara de Souza Oliveira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pro-apoptotic activity of ruthenium 1-methylimidazole complex on non-small cell lung cancer

(2018) Júlia Scaff Moreira Dias et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Phosphine/diimine ruthenium complexes with Cl − , CO, NO + , NO 2 − , NO 3 − and pyridine ligands: Pro-apoptotic activity on triple-negative breast cancer cells and DNA/HSA interactions

(2018) Henrique Vieira Reis Silva et al.   POLYHEDRON

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes

(2018) Kane McQuaid et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

(2018) Viktor Brabec et al.   COORDINATION CHEMISTRY REVIEWS

Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

(2018) Jen-Yang Tang et al.   SEMINARS IN CANCER BIOLOGY

In vitro leishmanicidal activity and theoretical insights into biological action of ruthenium(II) organometallic complexes containing anti-inflammatories

(2018) Victor M. Miranda et al.   BIOMETALS

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

(2018) Yasamin Dabiri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption

(2017) Dan Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti- Leishmania activity of new ruthenium(II) complexes: Effect on parasite-host interaction

(2017) Mônica S. Costa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi

(2017) Marzena Fandzloch et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Water soluble Ru(ii)–arene complexes of the antidiabetic drug metformin: DNA and protein binding, molecular docking, cytotoxicity and apoptosis-inducing activity

(2017) Durairaj Gopalakrishnan et al.   RSC Advances

Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis

(2016) Eva Iniguez et al.   ACTA TROPICA

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Investigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium(II) polypyridyl complex

(2016) Jin-can Chen et al.   INORGANIC CHEMISTRY COMMUNICATIONS

In vitro and in vivo antitumor activity of a novel carbonyl ruthenium compound, the ct-[RuCl(CO)(dppb)(bipy)]PF­6[dppb=1,4-bis(diphenylphosphine)butane and bipy=2,2′-bipyridine]

(2016) Andréa P. Carnizello et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells

(2016) Elisa Robles-Escajeda et al.   CELLULAR ONCOLOGY

How many times should we screen a chemical library to discover an anticancer drug?

(2015) Miguel López-Lázaro   DRUG DISCOVERY TODAY

Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands

(2015) Helena Guiset Miserachs et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia

(2014) Qiong Wu et al.   Metallomics

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Analysis of the cytotoxic effects of ruthenium–ketoconazole and ruthenium–clotrimazole complexes on cancer cells

(2013) Elisa Robles-Escajeda et al.   CELL BIOLOGY AND TOXICOLOGY

DNA/Protein Binding, Molecular Docking, and in Vitro Anticancer Activity of Some Thioether-Dipyrrinato Complexes

(2013) Rakesh Kumar Gupta et al.   INORGANIC CHEMISTRY

Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

(2013) Eva Iniguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Ruthenium–Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro

(2011) Francesco Caruso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Function of reactive oxygen species during animal development: Passive or active?

(2008) Luis Covarrubias et al.   DEVELOPMENTAL BIOLOGY