Review
Biochemistry & Molecular Biology
Luigi Donato, Domenico Morda, Concetta Scimone, Simona Alibrandi, Rosalia D'Angelo, Antonina Sidoti
Summary: Alzheimer's disease (AD) is the most widespread dementia globally, posing a major public health concern. Our understanding of this disease has significantly progressed, from a clinical and histopathologic description to a molecular comprehension. Unfortunately, there are no disease-modifying therapies currently available.
Review
Medicine, General & Internal
Naim Mahroum, Isa Seida, Sevval Nil Esirgun, Nicola Luigi Bragazzi
Summary: Infectious diseases can act in both predictable and unpredictable ways, leading to the emergence and reemergence of diseases. Previous research has correctly predicted the occurrence of emerging diseases, including COVID-19. Understanding past warnings and authorities' reactions and preparations is crucial for preventing and coping with future outbreaks.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Economics
Michele Ca'Zorzi, Michal Rubaszek
Summary: This paper evaluates the reliability of alternative equilibrium exchange rate assessments and finds that increasing the number of regressors does not necessarily improve the accuracy of predicting equilibrium exchange rates compared to a parsimonious BEER model and relative PPP model.
ECONOMIC MODELLING
(2023)
Review
Multidisciplinary Sciences
Pedro Pessoa, Steve Presse
Summary: It is common for scientific publishing to ask authors for reviewer suggestions. However, it is difficult to find friendly reviewers. To investigate this, we conducted a simulation and used Bayesian framework to classify suggested reviewers. We found that even with optimistic conditions, it would require hundreds of submissions to classify a small subset of reviewers. This highlights the robustness of the peer review system in allowing authors to suggest their own reviewers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Duck Min Seo, Sang Min Lee, Ji Won Park, Min-Jeong Kim, Hong Il Ha, Sun-Young Park, Kwanseop Lee
Summary: This retrospective study aimed to determine the number of times the ultrasound-guided attenuation parameter (UGAP) should be measured during the evaluation of hepatic steatosis. The study found that there were no significant differences between UGAP measurements repeated six times and those repeated 12 times, and the reliability was maintained. Therefore, six UGAP measurements seem sufficient for evaluating hepatic steatosis using UGAP.
Review
Biochemistry & Molecular Biology
Joschka Bauer, Nandhini Rajagopal, Priyanka Gupta, Pankaj Gupta, Andrew E. Nixon, Sandeep Kumar
Summary: Antibody-based biotherapeutics have encountered significant challenges and risks in their discovery and development, but have still emerged as successful pharmaceuticals. This review proposes the use of biopharmaceutical informatics, a conceptual framework that integrates computation and experimentation throughout the entire drug discovery process. The advancements in computational methods allow for better disease conceptualization, target identification, antibody design, and lead drug candidate optimization. By adopting biopharmaceutical informatics, affordable and effective biotherapeutics can be brought to patients more quickly.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Environmental Sciences
Alberto Pistocchi, Vanessa Parravicini, Guenter Langergraber, Fabio Masi
Summary: This study presents a spatial model based on population distribution and land cover to delineate agglomerations in the EU. The model identifies over 364,650 agglomerations with a population equivalent (PE) of 2000 or less, housing approximately 75 million inhabitants. The study also calculates the organic matter and nutrient loads these agglomerations can discharge, assuming primary wastewater treatment, and evaluates different treatment scenarios and their associated costs. The findings suggest that only a scenario of secondary treatment applied to all agglomerations above 1000 PE provides sufficient safety margins on the benefit-to-cost ratio (B/C).
WATER AIR AND SOIL POLLUTION
(2022)
Article
Allergy
Avad A. Mughal, Ashima Lowe, Sofia Hadjieconomou, Bevin Bhoyrul, Anthony Chu, Sue M. Cooper, Preshita Divekar, Glenda Hill, Catherine R. Holden, Graham A. Johnston, Ruth A. Sabroe, Krisztina Scharrer, Natalie Stone, Naila Usmani, Stephen M. Wilkinson
Summary: The study found that the minimum proportion of the population to be patch tested has increased to 1:550 over the past 20 years, indicating that more people should undergo patch testing for allergic contact dermatitis to maximize benefits.
CONTACT DERMATITIS
(2021)
Review
Cell Biology
Christine J. Watson
Summary: Research on mammary stem cells is currently facing controversies, but with innovative experimental approaches and technologies, there is a reevaluation of the concept of stem and progenitor cell hierarchy in progress.
TRENDS IN CELL BIOLOGY
(2021)
Article
Immunology
Jane Williams, Chris Degeling, Jodie McVernon, Angus Dawson
Summary: Vaccination plays a crucial role in pandemic planning and response, but the effectiveness of vaccines for novel pandemic viruses is uncertain. Ethical considerations and uncertainties must be taken into account when distributing vaccines.
Article
Geriatrics & Gerontology
Natalia Shilnikova, Franco Momoli, Mohamed Kadry Taher, Jennifer Go, Ian Mcdowell, Neil Cashman, Rowan Terrell, Elvin Iscan Insel, Jeremy Beach, Nicole Kain, Daniel Krewski
Summary: Cognitive abilities of older physicians may decline, potentially impacting clinical performance. However, physicians' self-assessment is often inaccurate, and perceiving cognitive decline may accelerate retirement decisions.
AGING & MENTAL HEALTH
(2023)
Editorial Material
Clinical Neurology
Steven Karceski
Summary: The importance of this question lies in whether relatives should be screened for aneurysms when a person is found to have an unruptured aneurysm.
Article
Andrology
Vinayak Madhusoodanan, Daniel C. Gonzalez, Alekhya Jampa, Daniel E. Nassau, Ranjith Ramasamy
Summary: Studies indicate a decline in sperm counts, with semen analysis being a safe, reliable, and cost-effective screening test that can assess male fertility and guide further treatment. Early intervention options, such as sperm cryopreservation, can be considered if defects in sperm parameters are identified in young men.
Article
Construction & Building Technology
Zhe Wang
Summary: This paper addresses the question of determining the most suitable sampling rate for temperature measurements in indoor environmental sensing. The study proposes a three step approach based on Fourier Analysis and Nyquist-Shannon Sampling Theorem, and applies it to a dataset of indoor temperature measurements in a medium-size office building. The findings indicate that a sampling rate of 10 minutes is adequate in capturing the periodic attributes of temperature variation, with a relative error of less than 3% for most thermal zones investigated.
BUILDING AND ENVIRONMENT
(2022)
Review
Dentistry, Oral Surgery & Medicine
Maria Pigg, Josephine Broden, Helena Fransson, Niklas Vareman
Summary: This paper explores the concept of uncertainty and its different dimensions, using persistent apical periodontitis associated with a previously root filled tooth as an example. The recognition and acceptance of uncertainty in clinical situations is necessary for making sound decisions and managing its consequences.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)