Review
Oncology
Vidhu B. Joshi, Omar L. Gutierrez L. Ruiz, Gina L. Razidlo
Summary: Pancreatic cancer is a deadly form of cancer that often involves metastasis. Understanding the cellular processes behind tumor cell invasion and dissemination in pancreatic cancer is crucial for developing effective treatments and inhibiting metastasis.
Review
Biochemistry & Molecular Biology
Korinn N. Murphy, Amanda J. Brinkworth
Summary: Focal adhesions (FAs) play a crucial role as dynamic signaling hubs within the cell, connecting intracellular actin with the extracellular matrix (ECM) to facilitate processes such as cell-ECM adhesion and migration. Pathogenic microbes often modify host cell actin cytoskeletons in order to enhance uptake and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Cell Biology
Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou, Paris A. Skourides
Summary: The study successfully prevented the action of FAK at focal adhesions by generating a specific peptide structure, thereby effectively inhibiting the migration and invasion of tumor cells and providing a new direction for the development of anti-metastatic agents.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Daniel J. Garcia-Dominguez, Nabil Hajji, Roser Lopez-Alemany, Sara Sanchez-Molina, Elisabet Figuerola-Bou, Francisco J. Moron Civanto, Santiago Rello-Varona, Eduardo Andres-Leon, Adrian Benito, Hector C. Keun, Jaume Mora, Oscar M. Tirado, Enrique de Alava, Lourdes Hontecillas-Prieto
Summary: The study evaluated the effects of a selective G9a histone methyltransferase inhibitor (BIX01294) on the metastatic process of Ewing sarcoma (EWS). The results showed that overexpression of G9a in EWS tumors is associated with poor prognosis. Furthermore, the inhibition of G9a with BIX01294 disrupted several steps of metastasis in vitro and reduced tumor growth and metastases in mouse models. The study also identified the sialidase NEU1 as a direct target and effector of G9a in the metastatic process of EWS.
Article
Biochemistry & Molecular Biology
Siyang Chen, Hui Ding, Kaiyun Wang, Kaiwen Guo
Summary: This study found that Wnt7b is highly expressed in colorectal cancer cells and may affect the proliferation, migration, and invasion of colorectal cancer cells by activating the Wnt/beta-catenin signaling pathway.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Pulin Che, Lei Yu, Gregory K. Friedman, Meimei Wang, Xiaoxue Ke, Huafeng Wang, Wenbin Zhang, Burt Nabors, Qiang Ding, Xiaosi Han
Summary: The study investigates the role of integrin alpha v beta 3 engagement with its ligand in metabolic reprogramming in glioblastoma cells. It was found that integrin alpha v beta 3 increases glucose uptake and aerobic glycolysis, while decreasing mitochondrial oxidative phosphorylation. The interaction of integrin alpha v beta 3 with osteopontin plays a crucial role in promoting metabolic shift towards glycolysis and inhibiting mitochondrial oxidative phosphorylation, leading to changes in cell behavior such as migration and invasion.
Article
Chemistry, Medicinal
Emilia Paunescu, Ghalia Boubaker, Oksana Desiatkina, Nicoleta Anghel, Yosra Amdouni, Andrew Hemphill, Julien Furrer
Summary: This study presents a structure-activity relationship study of a library of 56 compounds based on the trithiolato-bridged dinuclear ruthenium(II)-arene scaffold, with 34 newly designed drug candidates. Through in vitro biological assessment, potential compounds with anti-parasitic efficacy were identified.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Lihua Wang, Lei Yang, Tingting Zhuang, Xiuqing Shi
Summary: Exosomal miR-29b originating from pancreatic cancer cells protects HUVECs from pancreatic cancer cell-induced angiogenesis by attenuating the expression of ROBO1 and SRGAP2.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Engineering, Multidisciplinary
Rohan Abeyaratne, Eric Puntel, Giuseppe Tomassetti
Summary: A simple, transparent, two-dimensional, nonlinear model of cell reorientation is constructed, taking into account the deformation and orientation changes of stress fibers in response to substrate deformation and the detachment and reattachment process of focal adhesions. The evolution of the system is analyzed using a gradient flow kinetic law, revealing the regions where the fiber orientation remains unchanged and the orientation changes in order to minimize energy.
JOURNAL OF ELASTICITY
(2022)
Article
Biotechnology & Applied Microbiology
Dewang Fu, Ben Liu, Huamao Jiang, Zhaowei Li, Chenghui Fan, Li'e Zang
Summary: The research demonstrates that exosomal miR-19b-1-5p can suppress bladder cancer growth by decreasing ABL2, and it also inhibits malignant behaviors of bladder cancer cells.
Article
Cell Biology
Bin Tang, Shulan Dou
Summary: The PAF1/FLOT2 axis may serve as a potential therapeutic target for cervical cancer treatment. Knockdown of PAF1 suppresses the progression of CC by slowing down the FLOT2-mediated MEK/ERK1/2 pathway.
CELL ADHESION & MIGRATION
(2023)
Article
Biophysics
D. T. Nguyen, D. I. Pedro, A. Pepe, J. G. Rosa, J. I. Bowman, L. Trachsel, G. R. Golde, I. Suzuki, J. M. Lavrador, N. T. Y. Nguyen, M. A. Kis, R. A. Smolchek, N. Diodati, R. Liu, S. R. Phillpot, A. R. Webber, P. Castillo, E. J. Sayour, B. S. Sumerlin, W. G. Sawyer
Summary: Tumor invasion is driven by intrinsic and extrinsic stresses, reduced intercellular adhesion, and interactions with the extracellular matrix. This study investigates nonenzymatic mechanisms of invasion using a bioconjugated liquid-like solid (LLS) medium to mimic a loose capillary-like network. The LLS is made of soft granular microgels and allows for the exploration of 3D tumor invasion using confocal microscopy. The study reveals that tumor invasion is guided by the interstitial space and geometrical cues, independent of proteolytic ability.
Article
Pharmacology & Pharmacy
Junyuan Qu, Jing Li, Yongqiang Ma, Zhihui Wang
Summary: This study evaluated the function and mechanism of sanggenon C (SC) on breast cancer (BC) cells and found that it can suppress proliferation, mobility, and invasion, induce apoptosis and G0/G1 phase arrest in BC cells, as well as decrease HIF-1 alpha/VEGF pathway activity under hypoxia conditions. The findings suggest that SC is a potential agent for BC management.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Xian-Li Wang, Jing Tang
Summary: This study found that NaHS promotes the proliferation, migration, and invasion of HTR8/SVneo cells. It activates the FAK-Src and ERK signaling pathways, upregulates the activity of MMP-2 and MMP-9, and downregulates the expression of E-cadherin, thereby facilitating cell growth, migration, and invasion. These novel findings provide a strong foundation for the clinical application of H2S donor drugs.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhao Zhang, Ya-Jun Wang, Qiong Wu, Xiao-Hui Wu, Fu-Qiang Sun, Bao-Guo Wang, Wen-Jie Mei, Si-Dong Chen
AUSTRALIAN JOURNAL OF CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Zhao Zhang, Wenjie Mei, Xiaohui Wu, Xicheng Wang, Baoguo Wang, Sidong Chen
JOURNAL OF COORDINATION CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Zhao Zhang, Xiao-Hui Wu, Fu-Qiang Sun, Feng Shan, Jin-Chan Chen, Lan-Mei Chen, Yi-Sheng Zhou, Wen-Jie Mei
INORGANICA CHIMICA ACTA
(2014)
Article
Oncology
Qingyuan Yang, Zhao Zhang, Wenjie Mei, Fenyong Sun
JOURNAL OF CHEMOTHERAPY
(2014)
Article
Chemistry, Medicinal
Zhao Zhang, Hua-Jun Yu, Hui Huang, Hua-Hua Wang, Shang Wu, Hai-Yang Liu, Hai-Tao Zhang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Engineering, Biomedical
Zhao Zhang, Hua-Jun Yu, Hui Huang, Bei Wan, Shang Wu, Hai-Yang Liu, Hai-Tao Zhang
LASERS IN MEDICAL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Wei Cai, Xiaodong Chen, Xuejiao Men, Hengfang Ruan, Mengyan Hu, Sanxin Liu, Tingting Lu, Jinchi Liao, Bingjun Zhang, Danli Lu, Yinong Huang, Ping Fan, Junping Rao, Chunyan Lei, Jihui Wang, Xiaomeng Ma, Qiang Zhu, Lili Li, Xiuyun Zhu, Yujiao Hou, Shu Li, Qing Dong, Qing Tian, Lulu Ai, Wenjing Luo, Mengyun Zuo, Liping Shen, Congyan Xie, Hongzhong Song, Ganlin Xu, Kangdi Zheng, Zhao Zhang, Yongjun Lu, Wei Qiu, Tao Chen, Andy Peng Xiang, Zhengqi Lu
Summary: The composition of gut microbiota is associated with disease outcomes and exacerbated inflammation in patients with arteriosclerotic cerebral small vessel disease (aCSVD). Fecal bacterial extracts from aCSVD patients can activate neutrophils to increase the production of interleukin-17A (IL-17A), revealing a previously unrecognized implication of the gut-immune-brain axis in aCSVD pathophysiology with therapeutic implications.
Article
Biotechnology & Applied Microbiology
Wei Wang, Qiang Li, Ge Huang, Bing-yao Lin, Dongzi Lin, Yan Ma, Zhao Zhang, Tao Chen, Jie Zhou
Summary: This study utilized proteomic analysis to identify potential protein markers for distinguishing different levels of hepatocellular carcinoma (HCC) differentiation. Several proteins were found to be significantly up- or down-regulated in poorly differentiated HCC compared to well-differentiated HCC, suggesting their potential as biomarkers. These findings may contribute to improving the diagnosis and prognosis of HCC.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng
Summary: This study demonstrates that the L.p R3 strain significantly improves symptoms and pathological damage in mice with colitis, and influences immune function by regulating the Th17/Treg cell balance in DSS-induced colitis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jing Liu, Sheng Liu, Zhao Zhang, Xuejun Lee, Wenxuan Wu, Zhanlian Huang, Ziying Lei, Wenxiong Xu, Dabiao Chen, Xing Wu, Yang Guo, Liang Peng, Bingliang Lin, Yutian Chong, Xiangyu Mou, Mang Shi, Ping Lan, Tao Chen, Wenjing Zhao, Zhiliang Gao
Summary: Through metabolomic and metagenomic analysis, this study revealed significant changes in lactic acid, L-proline, and chlorogenic acid methyl ester (CME) in the sera of COVID-19 patients, as well as alterations in nasopharyngeal commensal bacteria. The presence of Gemella haemolysans and Leptotrichia hofstadii in the pharynx showed a significant positive correlation with serum CME, suggesting a potential anti-SARS-CoV-2 effect.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Kaining Han, Guangxin Feng, Tanghao Li, Zhuoyao Deng, Zhao Zhang, Jinmei Wang, Xiaoquan Yang
Summary: This study found that soybean 7S protein exhibits digestion resistance and can effectively prevent acute gastric mucosa damage. The un-digestible protein aggregates can penetrate into gastric mucus, increase the viscosity and compactness of the mucin layer, and reinforce the gastric mucus barrier properties. These findings are helpful in understanding the association between high consumption of non-fermented soybean foods and a decreased risk of gastric cancer.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, General & Internal
Yan-Xia Li, Kang-Di Zheng, Yu Duan, Hua-Juan Liu, Yu-Qun Tang, Jun Wu, Dong-Zi Lin, Zhao Zhang
Summary: This study aimed to identify potential serum biomarkers for diagnosing tuberculosis and monitoring its progression. Metabolite analysis of whole blood samples from patients and healthy controls revealed differential metabolites that may be associated with tuberculosis infection. The findings suggest that these metabolites could serve as indicators for diagnosing latent tuberculosis infection and monitoring disease progression.
Article
Gastroenterology & Hepatology
Ke Wang, Zhao Zhang, Zhi-Shuo Mo, Xiao-Hua Yang, Bing-Liang Lin, Liang Peng, Yang Xu, Chun-Yan Lei, Xiao-Dong Zhuang, Ling Lu, Rui-Fu Yang, Tao Chen, Zhi-Liang Gao
Summary: The gut microbiota in HBV-ACLF, HBV-Other and healthy individuals showed distinct differences in microbiome diversity, particularly in the ratio of cocci to bacilli and richness of specific genera. This indicates the potential of microbiota features as prognostic markers for HBV-ACLF.
Article
Chemistry, Inorganic & Nuclear
Zhao Zhang, Hua-Hua Wang, Hua-Jun Yu, Yu-Zhen Xiong, Hai-Tao Zhang, Liang-Nian Ji, Hai-Yang Liu
DALTON TRANSACTIONS
(2017)